| Palmers Property Management Ltd | Real estate | 2020 |
| Panyella Properties Ltd | Hospitality | 2021 |
| Paragon One Limited | Real estate | 2020 |
| Park View Rooms Ltd | Other services | 2014 |
| Paul Mackings Consulting Limited | Professional & scientific | 2013 |
| Paveclean (N.E) Limited | Administrative & support | 2006 |
| Paymentminds Limited | Professional & scientific | 2023 |
| PD Homes Limited | Real estate | 2020 |
| Pegg Wilson Ltd | Financial services | 2024 |
| Pentagon Commercial Management Newcastle Ltd | Real estate | 2014 |
| Pentagon Management (Newcastle) Ltd | Hospitality | 2014 |
| Performance HV Limited | Energy | 2018 |
| Pilates Union International Limited | Arts & recreation | 2019 |
| Pimvara Ltd | Health & social care | 2021 |
| Pine Rock Holdings Ltd | Financial services | 2020 |
| Pineline Building Services Ltd | Construction | 2010 |
| Pjmurray Ltd | Construction | 2019 |
| Ponteland Hand Wash Ltd | Administrative & support | 2025 |
| Postgate Services Ltd | Transport & logistics | 2009 |
| Powersols Limited | Information & communication | 2018 |
| Premier Car & Transport Services Ltd | Transport & logistics | 2019 |
| Premier Leisure Finance Limited | Administrative & support | 2017 |
| Premier Leisure Trading - Hedworth Hall Ltd | Hospitality | 2025 |
| Premier Leisure Trading Ltd | Hospitality | 2013 |
| Premier Physio (North East) Limited | Health & social care | 2011 |
| Premier Precision Engineering Limited | Professional & scientific | 1994 |
| Premier Trading Solutions Limited | Hospitality | 2010 |
| Proper Property (NE) Limited | Construction | 2020 |
| Property Rental Services Limited | Real estate | 2008 |
| Quality Assistance Site Services Limited | Information & communication | 2026 |
| Quality Surveillance Services Ltd | Professional & scientific | 2009 |
| R Brookes Ltd | Professional & scientific | 2016 |
| Raccolta DI Informazioni Ltd | Professional & scientific | 2016 |
| Real Estates (N.E.) Limited | Real estate | 2007 |
| Redpark Catering Limited | Hospitality | 2024 |
| Redpark Leisure Limited | Hospitality | 2023 |
| Regan DFA Limited | Health & social care | 2024 |
| Renewable and Technical Services Ltd | Professional & scientific | 2025 |
| Renova H Ltd | Real estate | 2026 |
| Revere Ltd | Real estate | 2025 |
| Revibe Consultancy Limited | Professional & scientific | 2018 |
| RH Aesthetics Ltd | Administrative & support | 2018 |
| Rickleton Village Centre Ltd | Real estate | 2021 |
| Riddicks Bar Ltd | Hospitality | 2024 |
| Riddicks Properties (North East) Ltd | Other services | 2024 |
| Riddicks Sports Bar Ltd | Hospitality | 2025 |
| Rio's Supplies Ltd | Wholesale & retail | 2023 |
| Rope and Wind Services Ltd | Manufacturing | 2024 |
| Rose Bursary Services Limited | Administrative & support | 2013 |
| Ross Finch - Podiatry Ltd | Health & social care | 2021 |
| RP Joinery North East Ltd | Construction | 2026 |
| RSM Electrical Services NE Ltd | Construction | 2026 |
| Rural Connectivity Group Ltd | Information & communication | 2024 |
| S&N Property (NE) Ltd | Real estate | 2020 |
| S.E.M Harrison Ltd | Administrative & support | 2019 |
| Samco ALL Trade Services Ltd | Construction | 2014 |
| Santon Projects Ltd | Professional & scientific | 2008 |
| Santon Property Group Ltd | Real estate | 2021 |
| SBA Health and Beauty Resources Ltd | Education | 2015 |
| Schnoobert Productions Ltd | Other services | 2022 |
| Schnoobert Promotions Ltd | Other services | 2021 |
| Scots Motor Services NE Ltd | Wholesale & retail | 2021 |
| Seaburn Offshore Services Ltd | Administrative & support | 2023 |
| Seaburn Properties Ltd | Real estate | 2025 |
| Seca Industrial Ltd | Construction | 2022 |
| Shearburn Capital Limited | Professional & scientific | 2024 |
| SIJ Blinds North East Ltd | Construction | 2023 |
| Simpson Property Consultants Limited | Professional & scientific | 2012 |
| Sinnesro Ltd | Other services | 2024 |
| Sloth London Ltd | Wholesale & retail | 2019 |
| Smart Scaff Ltd | Construction | 2026 |
| Smith & Sons Transport Ltd | Transport & logistics | 2021 |
| Smith Accountancy & Business Solutions Ltd | Professional & scientific | 2016 |
| Smiths Barbers Academy Ltd | Education | 2025 |
| Smiths Solutions NE Ltd | Professional & scientific | 2020 |
| SNS Commercial Ltd | Real estate | 2020 |
| SNS Paragon Ltd | Real estate | 2022 |
| South Shields Leisure Ltd | Hospitality | 2026 |
| Southwark Hand Car Wash and Valeting Services Ltd | Other services | 2015 |
| Southwick Pizza Ltd | Hospitality | 2019 |
| Spanish City (NE) Limited | Hospitality | 2016 |
| Sparklingscentsbysejm Ltd | Wholesale & retail | 2023 |
| Springways Blyth Ltd | Wholesale & retail | 2023 |
| SPS Sparadise Ltd | Other services | 2023 |
| Srlr Services Limited | Construction | 2025 |
| Ssmart Consultancy Ltd | Wholesale & retail | 2026 |
| ST Attewell Ltd | Construction | 2026 |
| ST Peters Byker Ltd | Hospitality | 2019 |
| Station Garages (East Boldon) Limited | Administrative & support | 2008 |
| Station Motor Company Ltd | Wholesale & retail | 2024 |
| Status Security North East Ltd | Administrative & support | 2024 |
| Stella Bars Ltd | Hospitality | 2018 |
| Sterlinglets LLP | | 2020 |
| Stevens Residential Limited | Real estate | 2020 |
| Stewart HAY Legal Services Ltd | Professional & scientific | 2013 |
| STK Services Ltd | Construction | 2019 |
| Stocktons Perfect Bites Ltd | Hospitality | 2021 |
| Stratford Supplies Ltd | Professional & scientific | 2013 |
| Stream Valley Farm Ltd | Professional & scientific | 2016 |
| Sunen Ltd | Wholesale & retail | 2015 |