| DC Stairlifts Limited | Professional & scientific | 2021 |
| DCS - N E Limited | Construction | 2017 |
| Dell View Maintenance Ltd | Households | 2025 |
| Denton West Social Ltd | Hospitality | 2024 |
| DH Leadership Alliance Limited | Professional & scientific | 2020 |
| Diane Jeffries Consultancy Limited | Education | 2022 |
| Direct Pizza NE Ltd | Hospitality | 2026 |
| Discount Supermarket (North East) Limited | Wholesale & retail | 2009 |
| Divergent Communities CIC | Education | 2026 |
| DK Architectural Services Limited | Professional & scientific | 2014 |
| DK Site Services Limited | Construction | 2014 |
| Doggie Diner Franchise Limited | Other services | 2016 |
| Domio Ltd | Real estate | 2023 |
| Dorchester Events Limited | Hospitality | 2014 |
| Dose Magazine Ltd | Extraterritorial | 2021 |
| Drone Photogrammetry Ltd | Professional & scientific | 2022 |
| Dscv Retail Limited | Hospitality | 2011 |
| DT Marine (NE) Ltd | Professional & scientific | 2019 |
| DT World Ltd | Construction | 2014 |
| Duncan Motors Ltd | Wholesale & retail | 2012 |
| Dunelm Security Ltd | Administrative & support | 2020 |
| Dunpark Limited | Real estate | 2022 |
| Dunston Social Ltd | Hospitality | 2024 |
| DW Property Developments Ltd | Administrative & support | 2023 |
| E.B.I.S.W Ltd | Health & social care | 2016 |
| East Boldon 2023 Ltd | Hospitality | 2023 |
| East Boldon Developments Limited | Construction | 2019 |
| East Boldon Motors Ltd | Wholesale & retail | 2011 |
| Eastern Touch Restaurant Ltd | Hospitality | 2015 |
| Easychill Limited | Manufacturing | 2005 |
| Eazy Apartments (N) Ltd | Real estate | 2022 |
| EB Road Safety Limited | Professional & scientific | 2020 |
| EBF Management Limited | Administrative & support | 1997 |
| Electrix Services NE Limited | Construction | 2017 |
| Equiconfidence Limited | Public administration | 2026 |
| Eriks Cycles Ltd | Wholesale & retail | 2026 |
| ESF Holdings Ltd | Professional & scientific | 2026 |
| Estates H Ltd | Real estate | 2020 |
| Ethicoll Limited | Professional & scientific | 2021 |
| Evercrew Limited | Hospitality | 2025 |
| Fairbourne Property Management Ltd | Real estate | 2024 |
| Fast FRY (West Boldon) Ltd | Hospitality | 2015 |
| Fielding Engineering Services Limited | Professional & scientific | 2022 |
| Fletchers Auto Parts Ltd | Wholesale & retail | 2024 |
| Flo-Culture Ltd | Information & communication | 2012 |
| Focus Consultancy Limited | Professional & scientific | 2024 |
| Fraser Longstaff Ltd | Professional & scientific | 2023 |
| From Scratch Construction Ltd | Manufacturing | 2019 |
| Front Street Properties Ltd | Real estate | 2024 |
| Fulwell Landscapes Maintenance Ltd | Administrative & support | 2014 |
| Fyra Restaurant Ltd | Hospitality | 2025 |
| G Baxter Auto Bodies Ltd | Wholesale & retail | 2022 |
| GAL Leisure Ltd | Hospitality | 2026 |
| Gallowgate Scaffolding Ltd | Construction | 2017 |
| Gathersight Ltd | Information & communication | 2021 |
| Geoo Holdings Limited | Real estate | 2021 |
| GET Carters (NE) Ltd | Wholesale & retail | 2012 |
| GFN Ltd | Professional & scientific | 2017 |
| Glamour N GLO Ltd | Other services | 2012 |
| Globetec Management Solutions Limited | Construction | 2014 |
| Goldenray Ltd | Wholesale & retail | 2010 |
| Golf Worx Limited | Wholesale & retail | 2009 |
| Goodman Electro-Mech Services Limited | Professional & scientific | 2012 |
| Green Air Renewables Ltd | Energy | 2012 |
| Greenside Ltd | Real estate | 2021 |
| H-R Enterprises NE Ltd | Professional & scientific | 2025 |
| HA Training Services Ltd | Education | 2014 |
| Hanriet Sales Limited | Wholesale & retail | 2024 |
| Harmony Medical Skin Clinic Community Interest Company | Health & social care | 2025 |
| Harrison Property Limited | Real estate | 2021 |
| Hass RA Access Ltd | Construction | 2020 |
| Heatone Ltd | Construction | 2012 |
| Heatone Properties Ltd | Real estate | 2022 |
| Hexham's Car Valeting and Services Ltd | Other services | 2015 |
| Hickfare Ltd | Transport & logistics | 2008 |
| Hide & Seek Accessories Ltd | Wholesale & retail | 2011 |
| Highlyrated Ltd. | Information & communication | 2002 |
| Home-Air Ltd | Energy | 2005 |
| Housd Ltd | Hospitality | 2024 |
| Hpma Engineering Ltd | Manufacturing | 2024 |
| Hugo Holdings (OBR) Ltd | Professional & scientific | 2023 |
| Hullywood Limited | Real estate | 2021 |
| Humber Estates Ltd | Real estate | 2014 |
| I B4E CIC | Education | 2023 |
| I.N Quality Support Ltd | Professional & scientific | 2019 |
| IC & EC Properties Limited | Real estate | 2014 |
| IDP Consult Limited | Construction | 2024 |
| Igwe Logistics Ltd | Transport & logistics | 2025 |
| Ineo Limited | Professional & scientific | 1997 |
| Informed Utilities Ltd | Professional & scientific | 2025 |
| Insiligence Ltd | Information & communication | 2021 |
| Inspire Corp Ltd | Hospitality | 2009 |
| International Trading Newcastle Ltd | Wholesale & retail | 2022 |
| Intersession Services Limited | Administrative & support | 2007 |
| Intreme Ltd | Manufacturing | 2010 |
| J & W Property Building Services Ltd | Households | 2017 |
| J M Dryden Ltd | Professional & scientific | 2014 |
| J T Roofing and Building Maintenance Limited | Construction | 2007 |
| Jacktrim Ltd | Real estate | 2010 |
| Jacqui Chapman Properties Limited | Real estate | 2023 |