| Wilplan Civils Limited | Construction | 2013 |
| Wilplan Landscapes Limited | Administrative & support | 2015 |
| Wilson's Steel Construction Ltd | Construction | 2022 |
| Wilson-Etheridge Ltd | Information & communication | 2018 |
| Wilson-Etheridge Properties Ltd | Real estate | 2021 |
| Wilsonwelderetai Limited | Wholesale & retail | 2025 |
| Wilson’S Construction Ltd | Construction | 2025 |
| Wiltshire & Co Business Service Ltd | Information & communication | 2015 |
| Winarch Ltd | Real estate | 2024 |
| Windcrew Workboats Limited | Transport & logistics | 2010 |
| Windpower Energy Limited | Construction | 2010 |
| Wingate B&B Ltd | Hospitality | 2024 |
| Wingate MOT Limited | Wholesale & retail | 2025 |
| Wingfield Construction North East Ltd | Construction | 2017 |
| Wingrove Motor Group Ltd | Wholesale & retail | 2026 |
| Wingrove Service & MOT Centre Limited | Wholesale & retail | 2025 |
| Wings for Feet Ltd | Professional & scientific | 2018 |
| Winn's Construction Limited | Construction | 2023 |
| Winnflow Plumbing Ltd | Manufacturing | 2023 |
| Winning ESH Holdings Limited | Financial services | 2021 |
| Winning ESH Trading Limited | Wholesale & retail | 2021 |
| Winter Armour Ltd | Manufacturing | 2026 |
| Winter Star Property Services Ltd | Construction | 2022 |
| Wisdom Wheel Limited | Real estate | 2019 |
| Withwards Business Leadership Ltd | Professional & scientific | 2022 |
| Witton Dragon Limited | Hospitality | 2024 |
| Witton Gilbert Holdings Ltd | Hospitality | 2025 |
| Witton Gilbert Nursery C.I.C. | Education | 2019 |
| WL Distillery Ltd | Manufacturing | 2019 |
| WLH Food Ltd | Wholesale & retail | 2018 |
| WLH Panda Ltd | Hospitality | 2021 |
| WOA Financial Planners Limited | Financial services | 2020 |
| Wojciechowska Cosmetics Ltd | Wholesale & retail | 2022 |
| Wolick Limited | Information & communication | 2019 |
| Wonderful Way CIC | Hospitality | 2021 |
| Wood Dragon Press Ltd | Information & communication | 2014 |
| Wood Funeral Director Ltd | Other services | 2021 |
| Wood N Wheels Regional Development Trust | Arts & recreation | 2007 |
| Woodlands Civils Ltd | Construction | 2024 |
| Woodridge Property (UK) Ltd | Real estate | 2021 |
| Woods Carpentry & Joinery Ltd | Construction | 2026 |
| Woodshed Workshop Community Interest Company | Manufacturing | 2018 |
| Woodside Ridge Limited | Hospitality | 2008 |
| Woodstone Interiors (NE) Limited | Construction | 2005 |
| Woolaballoo Limited | Wholesale & retail | 2010 |
| Woooosh Skates Ltd | Wholesale & retail | 2020 |
| Working Class Motorcycle Co Limited | Wholesale & retail | 2022 |
| Workplace & Storage Ltd | Transport & logistics | 2022 |
| Workshop Supplies North East Limited | Wholesale & retail | 2013 |
| Workstay Housing Ltd | Real estate | 2025 |
| World of Opportunity Ltd | Other services | 2022 |
| World Rich Construction & Properties Enterprise Limited | Real estate | 2018 |
| World Shaper Ltd | Information & communication | 2023 |
| Worldwide Quality Assurance Limited | Professional & scientific | 1999 |
| Worrall Tyre & Recovery Ltd | Wholesale & retail | 2020 |
| Wpcncservices Ltd | Professional & scientific | 2021 |
| WRB Groundworks Limited | Construction | 2025 |
| Wrestling Talent Limited | Arts & recreation | 2016 |
| WTH Construction Ltd | Professional & scientific | 2021 |
| Wunda Fill Aesthetics Limited | Other services | 2026 |
| WW Bars Limited | Hospitality | 2016 |
| WYH Food Limited | Hospitality | 2025 |
| Wyld Haeg Enterprises Ltd | Arts & recreation | 2019 |
| WYN Construction Limited | Construction | 1992 |
| WYN Group Ltd | Financial services | 2024 |
| WYN Limited | Construction | 2007 |
| Wynyard Building Limited | Real estate | 2013 |
| Wynyard Garden Village Homes Limited | Real estate | 2020 |
| Wynyard Red GAP Limited | Real estate | 2021 |
| X Minibuses North East Ltd | Transport & logistics | 2026 |
| X-Press Legal Services (Durham) Ltd | Professional & scientific | 2007 |
| Xcelerate Fitness Studios Ltd | Arts & recreation | 2025 |
| Xemo Limited | Manufacturing | 2010 |
| Xerosix Ltd. | Manufacturing | 2017 |
| XF Cleaning Ltd | Administrative & support | 2024 |
| Xltj Limited | Information & communication | 2022 |
| Xltss Global Ltd | Wholesale & retail | 2026 |
| Xltss Ltd | Construction | 2024 |
| Xtreme Elite Roofing Limited | Construction | 2022 |
| Y L W (NE) Ltd | Hospitality | 2026 |
| Y. S. Services Limited | Health & social care | 2002 |
| Yakka Strength Ltd | Wholesale & retail | 2021 |
| YAL Convenience Store Limited | Wholesale & retail | 2026 |
| Yalcin Trade Ltd | Wholesale & retail | 2023 |
| Yalla Homes Limited | Real estate | 2016 |
| Yaman Trade Ltd | Wholesale & retail | 2024 |
| Yardstick 36 Ltd | Other services | 2017 |
| Yarm Holdings Limited | Financial services | 2022 |
| YAUCC86 Ltd | Health & social care | 2023 |
| YD Express Limited | Hospitality | 2022 |
| Yekzen Ltd | Wholesale & retail | 2025 |
| Yellow Elephant Properties Ltd | Real estate | 2025 |
| Yellow Stone Equestrian Ltd | Manufacturing | 2025 |
| YES Haulage (Northumberland) Ltd | Transport & logistics | 2026 |
| Yesap Ltd | Wholesale & retail | 2026 |
| Yewande Amodu&Co Ltd | Health & social care | 2022 |
| YG E Commerce Ltd | Wholesale & retail | 2024 |
| Yigmuss Global Ltd | Wholesale & retail | 2024 |
| Yldncnr&Co Ltd | Wholesale & retail | 2025 |
| Yobenur Ltd | Health & social care | 2025 |