| Untold Biltong Ltd | Wholesale & retail | 2023 |
| UP North Communications Limited | Professional & scientific | 2015 |
| UP North Properties Limited | Real estate | 2000 |
| Upnorth Leisure Limited | Hospitality | 2012 |
| Upthy Ltd | Information & communication | 2026 |
| Urban Access Ltd | Construction | 2024 |
| Urban Falafel Limited | Hospitality | 2025 |
| Urban NEX Ltd | Wholesale & retail | 2025 |
| Urban Oven Ltd | Hospitality | 2024 |
| Urbanista Limited | Real estate | 2024 |
| URN Management Limited | Real estate | 2017 |
| Ushaw Moor Car Sales Ltd | Wholesale & retail | 2020 |
| Ushaw Moor Catholic Club Limited | Hospitality | 2000 |
| Ushaw Moor Diner Ltd | Hospitality | 2019 |
| Ushaw Moor Properties Ltd | Construction | 2024 |
| Ushaw Trustee Limited | Administrative & support | 2025 |
| Uslu Store Ltd | Wholesale & retail | 2025 |
| Utilergy GAS Limited | Professional & scientific | 2012 |
| Utopia for MEN Limited | Other services | 2014 |
| Utopia Plates Ltd | Wholesale & retail | 2018 |
| Utopia Properties NE Ltd | Real estate | 2023 |
| Utopia Tints Ltd | Wholesale & retail | 2019 |
| Uuniverse Limited | Professional & scientific | 2024 |
| Vahitco Limited | Wholesale & retail | 2025 |
| Valamar Limited | Wholesale & retail | 2024 |
| Vale Construction (NE) Ltd | Construction | 2025 |
| Valerian Consulting Limited | Professional & scientific | 2021 |
| Valorant K9 Academy Ltd | Other services | 2021 |
| Value Based Consulting Ltd | Professional & scientific | 2024 |
| Van Swift Logistics Ltd | Transport & logistics | 2026 |
| Vandor Ltd | Real estate | 2024 |
| Vantare Collective Ltd | Manufacturing | 2025 |
| Vantrex Ltd | Transport & logistics | 2026 |
| Vapingnortheast Ltd | Wholesale & retail | 2019 |
| Vasey Thompson Limited | Manufacturing | 1974 |
| Vass & Co Property Ltd | Hospitality | 2025 |
| Vasstech (Durham) Limited | Wholesale & retail | 2019 |
| Vauxhall Prototype Engineering Limited | Professional & scientific | 2015 |
| Vazraka Holdings Limited | Financial services | 2017 |
| VB (Philadelphia) Limited | Administrative & support | 2019 |
| VB Benton Limited | Administrative & support | 2020 |
| VB Turnbull Limited | Construction | 2011 |
| VBM Ltd | Information & communication | 2024 |
| VBT HW (Aislaby) Ltd | Real estate | 2023 |
| VBT RM Ltd | Real estate | 2022 |
| VBT Springwell Ltd | Real estate | 2025 |
| Veifo Ltd | Information & communication | 2024 |
| Velava Limited | Wholesale & retail | 2024 |
| VELO29 Cycling Events UK Ltd | Arts & recreation | 2022 |
| Veloura Trade Ltd | Wholesale & retail | 2026 |
| Ventura NE Ltd | Real estate | 2017 |
| Venture Aviation Consultants Limited | Professional & scientific | 2016 |
| Ventureship Limited | Administrative & support | 2026 |
| Venus Bridal UK Ltd | Wholesale & retail | 1996 |
| Venus Capital Group Ltd | Wholesale & retail | 2024 |
| Venus Leasing Limited | Financial services | 2017 |
| Venus Vehicle Solutions Limited | Financial services | 2007 |
| Verdant Carbon Zero Limited | Professional & scientific | 2025 |
| Verilliam Ltd | Real estate | 2025 |
| Vestbrown (ESH) Limited | Financial services | 2011 |
| Vestbrown (Espl) Limited | Real estate | 2011 |
| Vestbrown (Newco) Limited | Real estate | 2011 |
| Vestbrown Family Investments Limited | Real estate | 2019 |
| Vestbrown Limited | Real estate | 1982 |
| VF Group Online Ltd | Manufacturing | 2023 |
| Viaduct Residences Limited | Real estate | 2025 |
| Vicky Mccourt Consulting Ltd | Professional & scientific | 2023 |
| Victor One Risk Management Limited | Administrative & support | 2022 |
| Village Barber Skin Products Ltd | Manufacturing | 2013 |
| Villagegate Homes Ltd | Real estate | 2025 |
| Vimysoft Limited | Information & communication | 2007 |
| Violet and Ivy’S Florist Ltd | Wholesale & retail | 2026 |
| VIP Vets Ltd | Professional & scientific | 2011 |
| Virtue Hope C.I.C. | Education | 2025 |
| Virtuip Limited | Administrative & support | 2022 |
| Visionary (Durham) Limited | Administrative & support | 2015 |
| Visit County Durham | Professional & scientific | 2006 |
| Vital Fire Solutions Limited | Public administration | 2015 |
| Vivaldi Food Ltd | Hospitality | 2026 |
| Vivat Publishing Ltd | Information & communication | 2020 |
| Viveros Group Limited | Professional & scientific | 2015 |
| Vivid Renovations Limited | Construction | 2019 |
| VK Acquisitions Ltd | Real estate | 2022 |
| Voicentric Limited | Professional & scientific | 2002 |
| Voicentric Trustees Limited | Other services | 2019 |
| Volksparts Ltd | Wholesale & retail | 2021 |
| Volunt Ltd | Wholesale & retail | 2022 |
| Vorn Ventures Ltd | Professional & scientific | 2025 |
| Vortex Electrical Solutions Ltd | Manufacturing | 2021 |
| Voxdev Ltd | Information & communication | 2003 |
| Voyager Company Management Ltd | Wholesale & retail | 2025 |
| Voyza Ltd | Wholesale & retail | 2025 |
| VPI Products UK Limited | Manufacturing | 2020 |
| Vtraq Ltd | Education | 2021 |
| VUE Building and Developments Limited | Construction | 2026 |
| VW & Sons Construction Limited | Construction | 2023 |
| Vycore Interiors Limited | Construction | 2025 |
| Vythos Ltd | Wholesale & retail | 2022 |
| W & D Christie Developments Limited | Construction | 2017 |
| W. Smith (Durham) Holdings Limited | Financial services | 2021 |