| Nelson Developments (Durham) Limited | Construction | 2003 |
| Nelsons of Durham Ltd. | Extraterritorial | 1996 |
| Nepacs | Other services | 2001 |
| Nepacs Trading Limited | Hospitality | 2012 |
| Nepi Ltd | Construction | 2013 |
| Neptune Healthcare Ltd | Health & social care | 2025 |
| Neresin Ltd | Construction | 2023 |
| Nesa Trade Ltd | Wholesale & retail | 2025 |
| Nest EGG Solutions Ltd | Real estate | 2024 |
| Nest Northeast Ltd | Real estate | 2025 |
| Nest Nursery London Ltd | Education | 2022 |
| Netara Limited | Health & social care | 2023 |
| Networking Knowho Ltd | Information & communication | 2021 |
| Networkthreesixty Ltd. | Education | 2018 |
| Neus Properties Limited | Other services | 2010 |
| Neville Catering Ltd | Hospitality | 2019 |
| Nevolex Ltd | Wholesale & retail | 2025 |
| New Durham Courtyard Management Limited | Real estate | 2007 |
| New Elvet Living Limited | Real estate | 2024 |
| New Horizon Marketing and Advertising Ltd | Professional & scientific | 2019 |
| New Lanchester Hand Car Wash Ltd | Administrative & support | 2026 |
| New Leaf ASP Limited | Education | 2012 |
| New Lucky Limited | Hospitality | 2023 |
| New Soka Hazara Ltd | Wholesale & retail | 2017 |
| New Spicy Moments Ltd | Hospitality | 2020 |
| Newcastle Beauty Space Ltd | Other services | 2023 |
| Newcastle Smartzone Limited | Transport & logistics | 2015 |
| Newfield Estate Agents Limited | Real estate | 2013 |
| Newgate Pubs & Bars Company Limited | Hospitality | 2019 |
| Newhouse Boxing Club Ltd | Arts & recreation | 2023 |
| Newlands Sports Ltd | Wholesale & retail | 2020 |
| Newstreet Groundwork Services Limited | Construction | 2019 |
| Newton Hall Asset Finance Limited | Professional & scientific | 2004 |
| Newton Hall Roofing Ltd | Construction | 2013 |
| Newton Joinery & Building Ltd | Construction | 2022 |
| Newton Property's Development Ltd | Real estate | 2026 |
| Nexdeal Ltd | Wholesale & retail | 2025 |
| Nexio Tech Ltd | Information & communication | 2026 |
| Nexus Rigging Solutions Limited | Construction | 2015 |
| Nfrn Holdings Limited | Professional & scientific | 2002 |
| Ngaham Trading Company Limited | Real estate | 2019 |
| NGL (South Charlton) Ltd | Construction | 2022 |
| Niam Property Ltd | Professional & scientific | 2024 |
| Nicanor Holdings Limited | Financial services | 2025 |
| Nice Face Apparel Ltd | Wholesale & retail | 2022 |
| Nicks Pizza & Grill Ltd | Hospitality | 2020 |
| Nicky Hayer Ltd | Administrative & support | 2026 |
| Nico Rossi Limited | Wholesale & retail | 1999 |
| Nicola Rome Ltd | Extraterritorial | 2025 |
| Night Gxrl Records Ltd | Arts & recreation | 2024 |
| Nightfall Live Ltd | Professional & scientific | 2026 |
| NIK Installations Ltd | Manufacturing | 2026 |
| NIL Trade Ltd | Wholesale & retail | 2026 |
| Nile Palms Knowledge and Innovation Hub Ltd | Education | 2025 |
| Nima Sales & Marketing Ltd | Professional & scientific | 2015 |
| Nine Cubed (729) LLP | | 2009 |
| Nirusan Ltd | Real estate | 2020 |
| Nisa Inci Ltd | Wholesale & retail | 2024 |
| Nixon Couriers Ltd | Transport & logistics | 2020 |
| NJB Healthcare Ltd | Health & social care | 2022 |
| NJN Property Services Ltd | Real estate | 2024 |
| NJS Multi Utilities Limited | Construction | 2026 |
| NK Sproates Fire Consultants Limited | Other services | 2019 |
| NL Asset Management Limited | Financial services | 2023 |
| NM Electrical Services (NE) Ltd | Administrative & support | 2014 |
| Nmfire UK Ltd | Wholesale & retail | 2026 |
| NO More Grapes Limited | Information & communication | 2011 |
| NO More Marking Ltd | Information & communication | 2013 |
| Noah Barbers Pro Ltd | Other services | 2024 |
| NOF Energy Commercial Services Limited | Other services | 2008 |
| NOF Energy Ltd | Administrative & support | 2006 |
| NOO Lithium Limited | Professional & scientific | 2025 |
| NOO Noo's Experiences Community Interest Company | Other services | 2023 |
| Nordstar Consulting Ltd | Professional & scientific | 2019 |
| Nordstar Innovation Ltd | Information & communication | 2020 |
| Norfolk Hotel Limited | Hospitality | 2000 |
| Norma Lowther Catering Limited | Hospitality | 2008 |
| Norman Cornish Limited | Wholesale & retail | 2014 |
| North East Assemblies Limited | Manufacturing | 1995 |
| North East Auto Detailing Ltd | Wholesale & retail | 2023 |
| North East Blindscreens Ltd | Construction | 2024 |
| North East Building & Developments Limited | Construction | 2013 |
| North East Chamber of Commerce | Other services | 1994 |
| North East Clinics Ltd | Health & social care | 2021 |
| North East Commercial Flat Roofing Ltd | Construction | 2025 |
| North East Counselling and Therapy Ltd | Other services | 2017 |
| North East Curtainsiders Limited | Wholesale & retail | 2002 |
| North East Developments Ltd | Construction | 2022 |
| North East Door Systems Ltd | Manufacturing | 2020 |
| North East Drives & Patios Ltd | Construction | 2024 |
| North East Earthworks Ltd | Construction | 2016 |
| North East Environmental Limited | Administrative & support | 2013 |
| North East Farming Contractors Limited | Administrative & support | 2025 |
| North East Film Orchestra CIC | Arts & recreation | 2026 |
| North East Flat Roofing Solutions Ltd | Construction | 2024 |
| North East Foods Limited | Real estate | 2019 |
| North East Laser Cleaning Ltd | Administrative & support | 2026 |
| North East Logistics Limited | Transport & logistics | 2024 |
| North East Mixers Limited | Extraterritorial | 2018 |
| North East Prestige Ltd | Wholesale & retail | 2022 |