| Sabari Fruit and Vegetables Limited | Wholesale & retail | 2019 |
| Sablerose Limited | Real estate | 2021 |
| Sabrefile Limited | Professional & scientific | 1984 |
| Sadangu Ltd | Professional & scientific | 2024 |
| Sadie Davies Studio Ltd | Professional & scientific | 2026 |
| SAE Property Maintenance Limited | Construction | 2023 |
| Safecourt Limited | Wholesale & retail | 1993 |
| Safesure Plumbing and Heating Limited | Construction | 2015 |
| Safetron UK Limited | Wholesale & retail | 2025 |
| SAG PVT Ltd | Real estate | 2024 |
| Sage Bespoke Limited | Education | 2023 |
| Sago Construction Ltd | Construction | 2025 |
| Saihansrya Ltd | Real estate | 2025 |
| Sailfish Sports Limited | Arts & recreation | 2022 |
| Sajid Jewellers Limited | Wholesale & retail | 2021 |
| Sakawah Boys Ltd | Arts & recreation | 2022 |
| SAL Building Constructions Ltd | Construction | 2015 |
| Sales Training With Enfys Limited | Professional & scientific | 2022 |
| Salex Investments Limited | Real estate | 2016 |
| Salisbury Pubs Limited | Hospitality | 2003 |
| Salon Depot Ltd | Wholesale & retail | 2012 |
| Salus Properties and Land Limited | Real estate | 2021 |
| Salvator Pets Ltd | Wholesale & retail | 2025 |
| Salvatorian Consultants Limited | Professional & scientific | 2018 |
| Salvo Properties Limited | Real estate | 2013 |
| SAM Cambridge Limited | Hospitality | 2024 |
| SAM PAN Foods Limited | Wholesale & retail | 1979 |
| SAM PAN Property Holding Limited | Real estate | 2017 |
| Samat Properties Ltd | Real estate | 2021 |
| Samico Limited | Real estate | 1994 |
| Samuel's Charity | Health & social care | 2015 |
| Sana Education Limited | Professional & scientific | 2025 |
| Sandcastle IT Ltd | Information & communication | 2017 |
| Sandel Construction Group Limited | Construction | 2007 |
| Sandel Homes (Bedfordshire) Limited | Real estate | 2007 |
| Sanderson Trading Group Limited | Wholesale & retail | 2018 |
| Sandhill Way Limited | Hospitality | 2024 |
| Sandhurst Flavours Limited | Hospitality | 2019 |
| Sandpit Management Knebworth Ltd | Financial services | 2024 |
| Sandpit Way Limited | Professional & scientific | 2014 |
| Sands Flavours Limited | Hospitality | 2019 |
| Sandy Burton Engineering Limited | Manufacturing | 2019 |
| Sandy North UK Limited | Hospitality | 2025 |
| Sangfroid Services Ltd | Construction | 2020 |
| Santellas World Limited | Arts & recreation | 2021 |
| Sarah Flynn Neurological Physiotherapy Limited | Health & social care | 2023 |
| Saraqi Properties Ltd | Real estate | 2024 |
| Saraswathy Ltd | Real estate | 2024 |
| Sarb Transport Limited | Transport & logistics | 2023 |
| Sarema Properties Ltd | Real estate | 2018 |
| Saturnly Services Limited | Hospitality | 2020 |
| Saunders & Edmonds Limited | Real estate | 2025 |
| Saunders Artwork Limited | Professional & scientific | 2010 |
| Savage Collective Ltd | Professional & scientific | 2025 |
| Savanna Property Maintenance Limited | Construction | 2011 |
| Savasaachi London Ltd | Professional & scientific | 2024 |
| Saveinvest Ltd | Real estate | 2022 |
| Saving Hands and Rapid Progress (Sharp) | Health & social care | 2021 |
| Savvyshoperstore Ltd | Wholesale & retail | 2023 |
| Sawa Properties Ltd | Real estate | 2025 |
| Sawtry Motors Limited | Wholesale & retail | 2016 |
| SB Drylining Ltd | Construction | 2024 |
| SBL Holdco Limited | Financial services | 2019 |
| SBM Events Limited | Professional & scientific | 2021 |
| SCA Euroliner Limited | Professional & scientific | 1918 |
| SCA Pension Trustees Limited | Administrative & support | 1988 |
| Scale Aircraft Modeller Limited | Extraterritorial | 2001 |
| Scale Aircraft Modelling Limited | Extraterritorial | 2001 |
| Scanning and Data Solutions Limited | Information & communication | 2001 |
| Scarlett's World Limited | Other services | 2021 |
| Scent & Bloom Collection Ltd | Manufacturing | 2025 |
| Scholarova Ltd | Information & communication | 2026 |
| SCJ UK Consulting Limited | Professional & scientific | 2021 |
| SCL Firm Ltd | Construction | 2025 |
| Scoop N Swirl Ltd | Wholesale & retail | 2025 |
| Scotcher Investments Limited | Real estate | 2025 |
| Scote Lily Limited | Hospitality | 2019 |
| Scots Pine Limited | Information & communication | 2012 |
| Scott Construction and Groundworks Services Limited | Construction | 2026 |
| SCP Waterproofing Limited | Wholesale & retail | 2007 |
| SDC Consult Limited | Professional & scientific | 2025 |
| SDG Properties Limited | Real estate | 2017 |
| Sdrozd Ltd | Real estate | 2019 |
| Sea Education Consultants Limited | Education | 2010 |
| Seabridge Homes Limited | Construction | 2014 |
| Seabrook Holdco Ltd | Financial services | 2025 |
| Seahorse and the BEE Limited | Administrative & support | 2021 |
| SEB Cooling Ltd | Construction | 2025 |
| Sebprop Ltd | Real estate | 2025 |
| Second Eyes Ltd | Professional & scientific | 2026 |
| Secure Car Buyer Limited | Extraterritorial | 2023 |
| Secure Data Solutions Ltd | Information & communication | 2020 |
| Security 4 Drive Limited | Financial services | 2020 |
| Seebaran Suite Cleaning Company Ltd | Other services | 2024 |
| Seebaran Suite Limited | Administrative & support | 2016 |
| Seenoevil Eyewear Ltd | Wholesale & retail | 2025 |
| Seethe Ltd | Hospitality | 2022 |
| Seismic Systems Ltd | Households | 2025 |
| Seistech Energy Limited | Mining & quarrying | 2021 |
| Sekisui Alveo (GB) Limited | Administrative & support | 2013 |