| Streetwashuk Ltd | Administrative & support | 2017 |
| Streetwear Apparel Ltd | Other services | 2022 |
| Strengthvault Ltd | Arts & recreation | 2024 |
| Stress Free Renewables Limited | Wholesale & retail | 2025 |
| Strider Developments Ltd | Construction | 2025 |
| Striding Forward CIC | Education | 2026 |
| Strike 4 Ltd | Hospitality | 2024 |
| Stringer Electrical Ltd | Construction | 2015 |
| Strip'D Limited | Other services | 2019 |
| Strommy Ltd | Professional & scientific | 2022 |
| Strong 21 Ltd | Arts & recreation | 2021 |
| Strong Truck Limited | Transport & logistics | 2016 |
| Stronghaven Limited | Construction | 2008 |
| Stronghold Recovery Ltd | Other services | 2025 |
| Stroud Screening Limited | Construction | 2018 |
| Structural Fire AID Ltd | Extraterritorial | 2025 |
| Structurally-Sound Ltd | Real estate | 2016 |
| Structured Scale Ltd | Professional & scientific | 2021 |
| Structures Examination Services Ltd | Construction | 2022 |
| Strydrfit Ltd | Arts & recreation | 2026 |
| Sttuk Ltd | Arts & recreation | 2026 |
| Stuart M Ranby Agricultural Limited | Agriculture & fishing | 2021 |
| Stubbs Hall Lakes Limited | Agriculture & fishing | 2003 |
| Studcross Farme (Epworth) Management Company Limited | Households | 2003 |
| Student Discovery Learning Limited | Education | 2025 |
| Studentsvia Ltd. | Information & communication | 2013 |
| Studio 11B Limited | Information & communication | 2013 |
| Studio 360 Limited | Wholesale & retail | 2013 |
| Studio 46 Holding Limited | Financial services | 2020 |
| Studio 8 Doncaster Ltd | Other services | 2025 |
| Studio 805 Limited | Manufacturing | 2008 |
| Studio Capitale Group Ltd | Information & communication | 2022 |
| Studio JIM Limited | Professional & scientific | 2023 |
| Studio Lorne Limited | Arts & recreation | 2021 |
| Studio Mettle Ltd | Public administration | 2022 |
| Studio Synth Limited | Professional & scientific | 2018 |
| Studio Technology Limited | Information & communication | 2022 |
| Studio Two Creative Limited | Professional & scientific | 2010 |
| Studio-Portal CIC | Education | 2025 |
| Studiomodern Limited | Wholesale & retail | 2015 |
| Stuncroft Limited | Wholesale & retail | 2003 |
| Stuncroft Made to Measure Limited | Wholesale & retail | 2025 |
| Sturman's Maintenance Solutions Ltd | Other services | 2025 |
| Sturton Developments Limited | Construction | 2017 |
| Style by Reea Ltd | Wholesale & retail | 2024 |
| Style by Tash Ltd | Wholesale & retail | 2023 |
| Style Craft Directions Ltd | Wholesale & retail | 2019 |
| Style House Ltd | Wholesale & retail | 2025 |
| Style Sourcing Ltd | Wholesale & retail | 2025 |
| Stylus Innovations Limited | Other services | 2012 |
| Suarasan Limited | Transport & logistics | 2024 |
| Suave Empire Holdings Ltd | Wholesale & retail | 2025 |
| SUB Group Ltd | Water & waste | 2015 |
| SUB Nation (UK) PVT Ltd | Hospitality | 2011 |
| SUB Republic (UK) PVT Limited | Hospitality | 2012 |
| Subaru Surgery Ltd | Professional & scientific | 2021 |
| Sublimitprint Ltd | Wholesale & retail | 2021 |
| Subsite Surveys Ltd | Professional & scientific | 2017 |
| Subtrack Ltd | Professional & scientific | 2025 |
| Success Accountants Limited | Extraterritorial | 2012 |
| Successful From the Start Limited | Wholesale & retail | 2018 |
| Suciu Specialist Services Ltd | Administrative & support | 2025 |
| Sudanese Community in Doncaster CIC | Other services | 2026 |
| Sudascott Transport Services Limited | Transport & logistics | 1997 |
| Sudo Digital Ltd | Professional & scientific | 2018 |
| Suds and Studs RUG Wash Ltd | Other services | 2026 |
| SUE Bach Associates Limited | Health & social care | 2007 |
| SUE Clarke Associates Limited | Information & communication | 2019 |
| SUE Wragg Homes Ltd | Real estate | 2020 |
| Suffuse Aesthetics Ltd | Other services | 2024 |
| Sugar & Spice Bakers Ltd | Extraterritorial | 2026 |
| Sugar Junky Ltd | Wholesale & retail | 2024 |
| Sugar Mill Cottages Management Company Ltd | Households | 2022 |
| Suggest Systems Ltd | Information & communication | 2020 |
| Sukh Sahib Homes Ltd | Real estate | 2026 |
| Sula Creative Ltd | Professional & scientific | 2026 |
| Sullman Ltd | Arts & recreation | 2026 |
| Sultan Doncaster Ltd | Wholesale & retail | 2024 |
| Sultan Restaurant Ltd | Hospitality | 2021 |
| Summer's Cafe Limited | Hospitality | 2024 |
| Summers TM Ltd | Construction | 2020 |
| Summit Accounting Solutions Limited | Professional & scientific | 2017 |
| Summit Boardgames Ltd | Manufacturing | 2025 |
| Summit Buildworks Ltd | Extraterritorial | 2026 |
| Summit HC Ltd | Construction | 2022 |
| Summit Homecare Building Ltd | Construction | 2021 |
| Summit Homecare Limited | Construction | 2019 |
| Summit Homecare Windows Ltd | Construction | 2021 |
| Summit Interiors Ltd | Manufacturing | 2024 |
| Summit One Properties Ltd | Construction | 2025 |
| SUMMIT60 Ltd | Professional & scientific | 2022 |
| Summitedge Advisory Ltd | Extraterritorial | 2025 |
| Summitedge Services Ltd | Extraterritorial | 2026 |
| Sumnima Mortgages Ltd | Financial services | 2026 |
| Sumo Fluorescent Tube Crusher LLP | | 2016 |
| Sums Commercial Limited | Other services | 2016 |
| Sumudica Ltd | Wholesale & retail | 2024 |
| Sun Temple Empire Ltd | Wholesale & retail | 2024 |
| Sunalert Ltd | Extraterritorial | 2024 |
| Sunbeam Engineering Ltd | Manufacturing | 2017 |