| Scarbrook Electrical Limited | Construction | 2017 |
| Scarbrook Group Limited | Financial services | 2024 |
| Scarbrook Plumbing and Heating Limited | Construction | 2007 |
| Scarbrough Arms (Tickhill, Doncaster) Limited | Hospitality | 2023 |
| Scarda Properties Ltd | Real estate | 2025 |
| Scarface Emporium Ltd | Wholesale & retail | 2025 |
| Scarr L.E.V Services Limited | Manufacturing | 2015 |
| Scawsby Arkle Ltd | Hospitality | 2026 |
| Scawsby Car Wash Ltd | Wholesale & retail | 2021 |
| Scawsby Valeting Ltd | Administrative & support | 2026 |
| Scawthorpe Developments Limited | Construction | 2021 |
| Scawthorpe Library Community Association | Arts & recreation | 2015 |
| Scawthorpe Property Ltd | Real estate | 2025 |
| Sccb Ltd | Information & communication | 2023 |
| SCE Property Concepts Limited | Construction | 2022 |
| Sce-B Limited | Professional & scientific | 2023 |
| Sce-D Limited | Real estate | 2023 |
| Scene/Sounds Limited | Information & communication | 2022 |
| Scental Decants Ltd | Wholesale & retail | 2026 |
| Schofield Kitchens & Bathrooms Limited | Wholesale & retail | 2013 |
| Schofield's the Deli Ltd | Wholesale & retail | 2026 |
| School Journey Limited | Health & social care | 2024 |
| Schoonmaker Limited | Information & communication | 2023 |
| Schwank Limited | Manufacturing | 1973 |
| Schwihag UK Limited | Manufacturing | 2008 |
| SCI Case Management Ltd | Health & social care | 2026 |
| SCI Healthcare Ltd | Health & social care | 2026 |
| SCI Rehab Ltd | Health & social care | 2025 |
| SCI Rehabilitation Ltd | Health & social care | 2025 |
| Sci-Venture Limited | Information & communication | 2003 |
| Scissors & Shears Ltd | Other services | 2018 |
| SCL Electrical Services Ltd | Construction | 2020 |
| Scofix Ltd | Construction | 2023 |
| Sconto Capital Ltd | Financial services | 2024 |
| Sconto Import Ltd | Wholesale & retail | 2017 |
| Scooters Bar UK Ltd | Extraterritorial | 2019 |
| Scope Comms Ltd | Extraterritorial | 2015 |
| SCORE4 Homes Ltd | Real estate | 2024 |
| Scoreboard Competitions Ltd | Arts & recreation | 2024 |
| Scott Atkinson Photography Ltd | Professional & scientific | 2024 |
| Scott G Joinery Limited | Construction | 2022 |
| Scott Incorporated Limited | Other services | 2023 |
| Scott Marsden TM Ltd | Public administration | 2024 |
| Scotts TM Ltd | Public administration | 2025 |
| Scottsdale Projects Limited | Professional & scientific | 2025 |
| Scotty's Heroes Ltd | Administrative & support | 2017 |
| Scoutadmin Limited | Information & communication | 2025 |
| SCR Couriers Limited | Transport & logistics | 2025 |
| SCR Transport Ltd | Transport & logistics | 2023 |
| Scratch Music and Install Limited | Manufacturing | 2001 |
| Screed Doctor Limited | Construction | 2025 |
| Screenage Kicks Limited | Information & communication | 2025 |
| Scrooby Electrical Ltd | Manufacturing | 2026 |
| Scrubwear.Org Community Interest Company | Manufacturing | 2020 |
| Scruffyhipster Ltd | Professional & scientific | 2025 |
| Scuff Medics Limited | Wholesale & retail | 2016 |
| Scuff Medics Smart Repair Limited | Wholesale & retail | 2020 |
| Scunthorpe Radiators Ltd | Wholesale & retail | 2011 |
| SD Education Consultancy Limited | Education | 2023 |
| SD Fried Chicken Limited | Hospitality | 2019 |
| SD13 Ltd | Other services | 2026 |
| SDA Reform Movement | Other services | 2013 |
| SDB Capital Ltd | Real estate | 2022 |
| SDN Accountancy Limited | Professional & scientific | 2019 |
| SDV Technicians Ltd | Wholesale & retail | 2024 |
| SDW PVT Ltd | Health & social care | 2015 |
| SDY Building Contractors Ltd | Construction | 2022 |
| SE Bulmer Ltd | Arts & recreation | 2023 |
| Sea Lane Leisure Ltd | Real estate | 2020 |
| Sea Life Play Centre Limited | Arts & recreation | 2018 |
| Seacom Soft Limited | Wholesale & retail | 2022 |
| Seaglow Limited | Manufacturing | 2015 |
| Seagrey Limited | Extraterritorial | 2012 |
| SEAGULL27 Ltd | Hospitality | 2024 |
| Seal Property Management Ltd | Real estate | 2019 |
| Seal Property Packaging Ltd | Real estate | 2024 |
| Sealand Worldwide Ltd. | Extraterritorial | 2004 |
| Sean Murphy Logistics Ltd | Transport & logistics | 2013 |
| Sean Payne Plumbing & Heating Limited | Construction | 2014 |
| Sean Plunkett Sound Ltd | Information & communication | 2024 |
| Sean Poulter Ltd | Construction | 2001 |
| Sean Poulter Properties Limited | Real estate | 2022 |
| Seanychef Events Limited | Hospitality | 2025 |
| Search Gurus Ltd | Professional & scientific | 2018 |
| Searchadream Ltd | Information & communication | 2024 |
| Searush Limited | Extraterritorial | 2012 |
| Seasons Store Limited | Wholesale & retail | 2024 |
| Seatax Developments Limited | Real estate | 2020 |
| Seatax Group Limited | Financial services | 2025 |
| Seaview Escapes Ltd | Hospitality | 2017 |
| Seb's Haulage Ltd | Transport & logistics | 2026 |
| Seb's&Ss Logistics Ltd | Transport & logistics | 2023 |
| Sebalicious Ltd | Information & communication | 2020 |
| Sebastian Nicola Ltd | Transport & logistics | 2013 |
| Sebastian Skrodzki Ltd | Wholesale & retail | 2014 |
| Sebus Transport Ltd | Transport & logistics | 2013 |
| Secanim Limited | Manufacturing | 1948 |
| Secfire Alarms Ltd | Administrative & support | 2025 |
| Secret Beauty by EKD Ltd | Other services | 2021 |
| Section 24 Limited | Wholesale & retail | 2007 |