| Sado's Sound House Ltd | Education | 2020 |
| Safe Circuit Solutions Ltd | Manufacturing | 2023 |
| Safe Driving Ltd | Education | 2003 |
| Safe Electrical Services Limited | Construction | 1998 |
| Safe Elevation Scaffolding Ltd | Construction | 2024 |
| Safe Keeper Ltd | Wholesale & retail | 2025 |
| Safe Minds Safety Solutions Ltd | Professional & scientific | 2024 |
| Safe Scaffolding and Access Services Ltd | Construction | 2019 |
| Safe Stride Physiotherapy Limited | Health & social care | 2026 |
| Safe Transport Europe Ltd | Professional & scientific | 2022 |
| Safeguarding Scenarios Limited | Administrative & support | 2022 |
| Safesales Limited | Other services | 2017 |
| Safesite Technologies Ltd | Information & communication | 2026 |
| Safespaceapp Ltd | Extraterritorial | 2025 |
| Safesteps at Home Ltd | Health & social care | 2026 |
| Safety Coaching Academy Ltd | Education | 2018 |
| Safety Coaching Assessment Ltd | Education | 2018 |
| Safety Coaching Ltd | Professional & scientific | 2012 |
| Safety Mediation Limited | Professional & scientific | 2006 |
| Safety Training Limited | Education | 2016 |
| Saffron Bentley Ltd | Hospitality | 2026 |
| Saffron Joinery Ltd | Construction | 2013 |
| Saffron Spice DN9 Ltd | Hospitality | 2024 |
| Saffron Spice Doncaster Ltd | Hospitality | 2025 |
| Saffron Vale Hospitality Ltd | Extraterritorial | 2025 |
| Saffron Walden Scaffolding Ltd | Construction | 2019 |
| Safi Optical Ltd | Professional & scientific | 2016 |
| Sagehut Consulting Limited | Real estate | 2022 |
| Sagehut Properties Limited | Real estate | 2023 |
| Sagep Truck Ltd | Transport & logistics | 2024 |
| Sagu Catering Ltd | Hospitality | 2020 |
| Sahinoglu 27 Limited | Hospitality | 2023 |
| Sahinoglu Estate Limited | Real estate | 2023 |
| SAI Commercials Ltd | Real estate | 2024 |
| SAI Convenience UK Ltd | Wholesale & retail | 2022 |
| SAI Fuels Ltd | Wholesale & retail | 2019 |
| Sailors Office Ltd | Extraterritorial | 2024 |
| Saint Vincent's Mission Doncaster Ltd | Other services | 2025 |
| Sainte Bethesda Care Ltd | Administrative & support | 2026 |
| Sait Shipping Limited | Water & waste | 2020 |
| Saito Ltd. | Construction | 2017 |
| Saivarun Ltd | Wholesale & retail | 2024 |
| Sakari Investments Limited | Real estate | 2018 |
| Sakethram Limited | Real estate | 2024 |
| Sako Market Ltd | Wholesale & retail | 2022 |
| Salahudin Fried Chicken Ltd | Hospitality | 2020 |
| Salamander Promotions Limited | Transport & logistics | 2015 |
| Salamander TM Ltd | Public administration | 2022 |
| Salcombe Regis Park Ltd | Hospitality | 2014 |
| Sally Aesthetics Ltd | Other services | 2025 |
| Sally Clarke Furniture Ltd | Manufacturing | 2021 |
| Salma Ltd | Other services | 2025 |
| Salman Food Ltd | Hospitality | 2019 |
| Salon 15 Limited | Other services | 2004 |
| Salon Rated Ltd | Administrative & support | 2022 |
| Salt & Pepper Chinese Ltd | Hospitality | 2020 |
| Salt and Pepper Distribution Ltd | Wholesale & retail | 2025 |
| Salt END Power Limited | Extraterritorial | 2017 |
| Salt N Vinegar (PSP) Ltd | Hospitality | 2020 |
| Salter Accounting Services Ltd | Professional & scientific | 2021 |
| Salters Property Holdings Ltd | Real estate | 2025 |
| Saltino Brothers Limited | Real estate | 2006 |
| Salud SJP Limited | Hospitality | 2021 |
| Salusa Engineering & Simulation Ltd | Professional & scientific | 2025 |
| Salusa Engineering Ltd | Professional & scientific | 2024 |
| Salutation Doncaster Ltd | Hospitality | 2016 |
| Salvancarpeting Limited | Manufacturing | 2025 |
| Salvis Consultants Limited | Administrative & support | 2016 |
| SAM & Daniel Ltd | Hospitality | 2020 |
| SAM Assured Ltd | Information & communication | 2023 |
| SAM Carriage Ltd | Transport & logistics | 2021 |
| SAM Daines Limited | Wholesale & retail | 2007 |
| SAM Hall Limited | Transport & logistics | 2020 |
| SAM Longthorp Limited | Agriculture & fishing | 1964 |
| SAM Property Builder Ltd | Construction | 2022 |
| SAM. Roofing Ltd | Construction | 2026 |
| Samba Soccer Schools Doncaster Ltd | Arts & recreation | 2025 |
| Sammut Enterprises Ltd | Real estate | 2025 |
| Sammy Restaurants Limited | Hospitality | 2008 |
| Sammyadd Limited | Wholesale & retail | 2023 |
| Samnica Limited | Wholesale & retail | 2025 |
| Sampling Engineering Systems Limited | Manufacturing | 2000 |
| Samson Mens Hair Replacement Specialists Limited | Other services | 2021 |
| Samsun Limited | Hospitality | 2026 |
| Samuel Hodge Group Limited | Financial services | 2021 |
| Samuel Hodge Holdings Limited | Financial services | 2010 |
| Samuel Hodge Limited | Professional & scientific | 1897 |
| SAN Pizza Limited | Hospitality | 2025 |
| SAN SAN PROPERTIES01 Ltd | Construction | 2022 |
| SAN Valentin Limited | Real estate | 2024 |
| Sana Property (Yorkshire) Limited | Real estate | 2023 |
| Sanan Security and Facilities Managment Ltd | Construction | 2025 |
| Sanave MED Limited | Health & social care | 2010 |
| Sanctum D1G1TAL Ltd | Professional & scientific | 2026 |
| Sandall Esolutions Ltd | Information & communication | 2015 |
| Sandall Heating Services Ltd | Construction | 2021 |
| Sandall Investments Limited | Wholesale & retail | 1995 |
| Sandall Joinery Limited | Manufacturing | 2019 |
| Sandall Park Cafe Ltd | Hospitality | 2014 |
| Sandall Park Leisure Ltd | Real estate | 2014 |