| ROY Allen (Properties) Limited | Real estate | 2025 |
| Roydon Service Station Limited | Extraterritorial | 2010 |
| Rozilla Films Ltd | Other services | 2023 |
| RP Management Consultancy Ltd | Professional & scientific | 2023 |
| RTB Homes (East Anglia) Ltd | Construction | 2010 |
| Ruddington and East Leake Veterinary Centre Limited | Professional & scientific | 2002 |
| Rushford Services Limited | Households | 2001 |
| Rushton Food Safety Ltd | Professional & scientific | 2026 |
| Ryes Energy Ltd | Construction | 2013 |
| S & T Proudfoot Limited | Extraterritorial | 2016 |
| S a Pubs Limited | Hospitality | 2011 |
| S D X Properties Limited | Real estate | 2004 |
| S Hines Groundworks Limited | Construction | 2008 |
| S Nunn Media Services Ltd | Other services | 2025 |
| S P Gaskin Builders Limited | Construction | 2012 |
| S.Merrick Hill (Commercial) Limited | Financial services | 1968 |
| S.O.G Scaffolding Ltd. | Construction | 2010 |
| S.S.C. East Limited | Construction | 2017 |
| Safe STS Offshore Limited | Administrative & support | 2024 |
| Safebetter Limited | Wholesale & retail | 1988 |
| Sakamoto Industries Limited | Other services | 2023 |
| Salt & Pepper Street Ltd | Hospitality | 2019 |
| SAM Wale Productions Ltd | Information & communication | 2018 |
| Samantha Green Driving Services Limited | Transport & logistics | 2025 |
| Samrich Limited | Households | 2007 |
| Sanark Ltd | Real estate | 2012 |
| Sandringham Stud & Bloodstock Limited | Agriculture & fishing | 2024 |
| Sandy Lane Nursery Limited | Wholesale & retail | 2018 |
| Sarsons Meadow Hopton Management Company Limited | Households | 2024 |
| Sassy's Floral Design Ltd | Wholesale & retail | 2018 |
| SAV Travel Ltd | Administrative & support | 2025 |
| Sbcc Ltd | Transport & logistics | 2022 |
| SC Norfolk Limited | Real estate | 1976 |
| Scaleability Support Limited | Education | 2024 |
| SCG Agri Services Ltd | Agriculture & fishing | 2012 |
| School Lane Spooner ROW Management Company Limited | Households | 2025 |
| Scintilla Group Ltd | Education | 2015 |
| SDM Trading & Developments Limited | Construction | 2019 |
| Seadown Veterinary Services Ltd | Professional & scientific | 2005 |
| Sector 3 Group Ltd | Professional & scientific | 2025 |
| Selborne Associates Limited | Professional & scientific | 2020 |
| Selected Services Limited | Real estate | 1964 |
| Selina Grazia Ltd | Wholesale & retail | 2025 |
| Seven Acres Construction Ltd | Construction | 2023 |
| Severn Edge Equine Limited | Professional & scientific | 2015 |
| Severn Edge Farm Limited | Professional & scientific | 2015 |
| Severn Edge Holdings Limited | Professional & scientific | 2015 |
| Severn Edge Veterinary Group Limited | Professional & scientific | 2015 |
| Shelbourne Reynolds Limited | Manufacturing | 2015 |
| Shelfanger Fish & Chips Ltd | Hospitality | 2020 |
| Shop Take Two Limited | Wholesale & retail | 2020 |
| Shorelands Conservation CIC | Agriculture & fishing | 2022 |
| Shubraka Opportunities Limited | Professional & scientific | 2014 |
| Shyanoli Limited | Financial services | 2020 |
| Silverton Veterinary Practice Limited | Professional & scientific | 2012 |
| Simba Sports Products Ltd | Arts & recreation | 2015 |
| Simon Atkinson Holdings Limited | Financial services | 2003 |
| Simon Moate NED and Advisory Services Limited | Professional & scientific | 2015 |
| Simonds of Botesdale Limited | Wholesale & retail | 1988 |
| Simplifly Limited | Information & communication | 2023 |
| Simply Sound Limited | Wholesale & retail | 2012 |
| Simpsons Garage (GT. Yarmouth) Limited | Wholesale & retail | 1986 |
| Sixty Four Group Ltd | Construction | 2022 |
| SJB Designs (EA) Limited | Professional & scientific | 2015 |
| Skeleton Castle Ltd | Information & communication | 2025 |
| Skinny Cat Creative Ltd | Professional & scientific | 2021 |
| Slick Reship Ltd | Other services | 2023 |
| SLW Consulting Ltd | Professional & scientific | 2001 |
| Smallchance Limited | Information & communication | 2010 |
| Smith UK Ltd | Professional & scientific | 2002 |
| Smithline Trading Ltd | Wholesale & retail | 2025 |
| SMK Financial Services Ltd | Financial services | 2026 |
| SN Sudbury Limited | Construction | 2025 |
| Snake Eyes Enterprises Ltd | Financial services | 2025 |
| Snetterton Commercial Properties Limited | Construction | 2017 |
| Snetterton Telecom Limited | Information & communication | 2022 |
| Soakfitness Ltd | Arts & recreation | 2018 |
| Social Voltage Ltd | Professional & scientific | 2020 |
| Socially Adept Limited | Professional & scientific | 2017 |
| Softrader Limited | Information & communication | 2000 |
| Softwood Import Services Limited | Other services | 1964 |
| Solam Ltd | Wholesale & retail | 2016 |
| Sole MAN Ltd | Other services | 2002 |
| Sonik Homes Ltd | Real estate | 2026 |
| Sound Technology Limited | Wholesale & retail | 1979 |
| Source Distribution Ltd | Extraterritorial | 2006 |
| Source Online Limited | Wholesale & retail | 2007 |
| Sovereign Group (UK) Limited | Information & communication | 2007 |
| Spectacles at Home Ltd | Health & social care | 2011 |
| SPH & Partners Limited | Financial services | 2019 |
| Sphere Products Ltd | Manufacturing | 2014 |
| Spinning Wheel Ltd | Arts & recreation | 2011 |
| Spotlight Costumes Ltd | Manufacturing | 2013 |
| Sprayco Commercial Limited | Construction | 2023 |
| Ss&L Group Ltd | Financial services | 2025 |
| Ss&L Property Limited | Real estate | 2025 |
| Ssas Diagonal Properties Limited | Financial services | 2025 |
| SSC Fabrications Ltd | Manufacturing | 2021 |
| SSC Holdings East Ltd | Real estate | 2021 |
| Standish Estates Limited | Real estate | 1965 |