| Eaton Carpentry Limited | Construction | 2008 |
| Eaton House Management Company Limited | Households | 1980 |
| EBC Trading Limited | Information & communication | 1993 |
| Eco Electric Limited | Manufacturing | 2004 |
| Edible Art Patisserie Ltd | Other services | 2017 |
| Edison Electrical Limited | | 1988 |
| Edmondson Food Ltd | Hospitality | 2005 |
| Edps Limited | Professional & scientific | 2002 |
| Edward Bowditch Limited | Wholesale & retail | 2003 |
| Edwards & Partners (Sidmouth) Ltd | Real estate | 2005 |
| Edwards Studios Ltd | Information & communication | 2022 |
| Efoil Cornwall Limited | Wholesale & retail | 2021 |
| Elmdene (Exmouth) Limited | Information & communication | 1985 |
| Elmgate Limited | Construction | 2000 |
| Energenix Ltd | Other services | 2023 |
| Enterprise Assist Limited | Professional & scientific | 2005 |
| Entertaining Food Limited | Hospitality | 2005 |
| Enthuse (SW) Limited | Professional & scientific | 2008 |
| Environment UK Limited | Professional & scientific | 2000 |
| Enzo Life Sciences (UK) Limited | Professional & scientific | 1991 |
| Epsom Motor Group Limited | Extraterritorial | 1982 |
| Equity Matters Limited | Professional & scientific | 2006 |
| ESH (Assets) Limited | Water & waste | 2007 |
| Essen Solutions Ltd | Other services | 2023 |
| Et&R Services Limited | Other services | 2007 |
| Eulma Ltd | Other services | 2022 |
| Euro Phyto France Limited | Administrative & support | 1998 |
| Euro-Compta Limited | Professional & scientific | 1999 |
| European Community Telework/Telematics Forum (Ectf) Ukeig | Financial services | 1993 |
| Exact Engineering (Hose & Fittings) Company Limited | Other services | 1995 |
| EXE Events Limited | Administrative & support | 2026 |
| EXE Finishing Supplies Limited | Transport & logistics | 1987 |
| EXE Mills Carpets Limited | Wholesale & retail | 2003 |
| Exeasphalt Limited | | 1984 |
| Exeleigh Residual Products Limited | Real estate | 1950 |
| Exeter Airport Fuel Services Limited | Transport & logistics | 2025 |
| Exeter Arts Trading Services Limited | Hospitality | 2007 |
| Exeter Carpet Company Limited | Wholesale & retail | 2004 |
| Exeter Diocesan Trust(The) | Professional & scientific | 1916 |
| Exeter Historic Buildings Trust | Real estate | 1996 |
| Exeter Motor Group Limited | Extraterritorial | 1979 |
| Exeter Skypark Limited | Professional & scientific | 1986 |
| Exeter Tool Shop Limited | Wholesale & retail | 2007 |
| Exmoor Coast Boat Cruises Limited | Agriculture & fishing | 1996 |
| Exmoor Fascias Limited | Administrative & support | 2003 |
| Extra Effect Limited | Information & communication | 1999 |
| F. C. & J. Wheaton Limited | Real estate | 1974 |
| F.J. & L.H. Mitchell Limited | | 1972 |
| F.J.C. Property Development Services Limited | Construction | 2006 |
| F.J.Emery(Oils)Limited | Wholesale & retail | 1960 |
| F.T.T. (G.B.) Limited | Education | 2003 |
| Fabina Jewellery Ltd | Manufacturing | 2019 |
| Falconhelm Limited | | 1984 |
| Fannar Ltd | Transport & logistics | 2018 |
| Farmco Limited | Administrative & support | 2004 |
| Farzin Shahmehr Limited | Professional & scientific | 2004 |
| FAY Pedler Clinic Limited | Health & social care | 2007 |
| Features (Realms of Fantasy) Limited | Water & waste | 1990 |
| Feedwell Limited | Hospitality | 2025 |
| Feisty Foods Ltd | Manufacturing | 2018 |
| Fenster Limited | Construction | 2006 |
| Fields of Sidmouth Limited | Wholesale & retail | 1993 |
| Fifty Crates of Crafts (Bude) Limited | Wholesale & retail | 2026 |
| Filom Ltd | Administrative & support | 2018 |
| Fire Secure Ltd | Manufacturing | 2018 |
| Fire Security UK Limited | Construction | 2007 |
| Firehouse Solutions Limited | Information & communication | 2005 |
| Firmset Limited | Arts & recreation | 1982 |
| First Resilience Group Limited | Financial services | 2009 |
| Firstgano Ltd | Administrative & support | 2020 |
| Fish for Kings Limited | Wholesale & retail | 2005 |
| Five Marine Place Management Company Limited | Administrative & support | 2002 |
| Fjlc Consulting Limited | Professional & scientific | 2024 |
| Flavel Centre Limited | Arts & recreation | 1999 |
| Flavel Centre Trust | Education | 2000 |
| Flear House Interiors Limited | Wholesale & retail | 1998 |
| Flojo Ltd | Wholesale & retail | 2003 |
| Fordstam Consultancy Limited | Administrative & support | 2006 |
| Forest Vale Management (NO.2) Limited | Households | 1993 |
| Forestreet Management Company Ltd | Households | 2018 |
| Forgecom Ltd. | Information & communication | 1999 |
| Fortuna and Virtu Limited | Wholesale & retail | 2000 |
| Foster Hall Limited | Households | 2002 |
| FOX & Downing Limited | | 1985 |
| Frederick Sherrell Limited | Professional & scientific | 1993 |
| Freeth Lettings Ltd | Wholesale & retail | 2025 |
| French Property Owners Club Limited | Extraterritorial | 1990 |
| Frenchbeer Farm Limited | Agriculture & fishing | 2005 |
| Frogmore Solutions Limited | Information & communication | 1995 |
| Full-Tilt Computing Limited | Information & communication | 2000 |
| Future First Financial Solutions Limited | Financial services | 2003 |
| Fuzed Group Holdings Ltd | Financial services | 2025 |
| FWF (SW) Limited | Real estate | 2023 |
| G Floyd CTA Limited | Extraterritorial | 2006 |
| G R Pook Engineering Limited | Manufacturing | 1989 |
| G S Mechanical Limited | Construction | 1987 |
| G W Associates Limited | Real estate | 1997 |
| G.S. & P. Ames Limited | Wholesale & retail | 2005 |
| Gale & Snowden Architects Ltd | Professional & scientific | 2005 |
| Galway House Management Company Limited | Households | 2002 |