| Station Taxis (Newton Abbot) Limited | Transport & logistics | 2005 |
| Steiner Management Limited | Professional & scientific | 1987 |
| Stellar YAO Limited | Manufacturing | 2025 |
| Stensus Ltd | Transport & logistics | 2018 |
| Stepping Stones Day Nursery (SW) Ltd | Health & social care | 2013 |
| Steve Bradford Builders Limited | Construction | 2006 |
| Steve Eastland Design Limited | Professional & scientific | 2003 |
| Steve Mangeng Ltd | Wholesale & retail | 2004 |
| Steve Norris Limited | Professional & scientific | 1997 |
| Steve Palmer Transport Limited | Transport & logistics | 2021 |
| Stevens Homes Ltd | Construction | 1986 |
| Sticky Wicket Limited | Arts & recreation | 2004 |
| Stoat Park Management Limited | Extraterritorial | 2006 |
| Stoneman Stainless Limited | Manufacturing | 2004 |
| Stover Enterprises Limited | Education | 1996 |
| Stover School Association | Education | 1956 |
| Strandmere Limited | Real estate | 1997 |
| Stretcholt Contracting Ltd. | Administrative & support | 2005 |
| Stride Development (Heathfield) Limited | Wholesale & retail | 2003 |
| Stuart Witheridge (Homes) Limited | | 1983 |
| Stuyvesant Advisory Ltd | Financial services | 2018 |
| Subiaco Associates Limited | Professional & scientific | 2003 |
| Sunita & Partners Ltd | Hospitality | 2025 |
| Supacat Limited | Manufacturing | 1980 |
| Susa Fishing Limited | Agriculture & fishing | 2000 |
| Swell Architecture Ltd | Professional & scientific | 2025 |
| Swiftprint (S.W.) Ltd | Manufacturing | 2002 |
| Sycon,Limited | Extraterritorial | 1949 |
| Synergy 4 Property Services Ltd | Construction | 2005 |
| Synergyloop Ltd | Other services | 2023 |
| T & J Deane Limited | Agriculture & fishing | 2004 |
| T & T Property Improvements Limited | Construction | 2003 |
| T H Diving Services Limited | Professional & scientific | 2003 |
| T. Broom Construction Ltd | Construction | 2001 |
| T.A.W Builders and Bricklayers Limited | Administrative & support | 2016 |
| T.P. Pumps Holdings Limited | Financial services | 2022 |
| T.P. Pumps Limited | Manufacturing | 2003 |
| T.W. Concrete Products Limited | | 1985 |
| Tabitha Publishing Limited | Arts & recreation | 1976 |
| Taking Care Personal Alarms Limited | Other services | 1980 |
| Tanning Studio (Plymouth) Limited | Other services | 2005 |
| Tavistock Business Consultancy Limited | Professional & scientific | 2001 |
| Tavistock Stove and Fireplace Limited | Wholesale & retail | 2022 |
| Tax & Business Solutions Ltd | Professional & scientific | 2002 |
| TBB Plumbing & Heating Ltd | Wholesale & retail | 2004 |
| Techgenix Ltd | Information & communication | 2024 |
| Technical Utilities Limited | Professional & scientific | 1988 |
| Technology Transfer South West Limited | | 1990 |
| Teign Diving Limited | Professional & scientific | 2003 |
| Teign Metal Finishes Limited | Manufacturing | 2000 |
| Teign Scene and Heard Limited | Wholesale & retail | 2003 |
| Teignview Veterinary Group Limited Liability Partnership | | 2003 |
| Tekous Ltd | Transport & logistics | 2020 |
| Teodom Ltd | Other services | 2024 |
| Tern Quay Limited | Real estate | 2007 |
| TG Bookkeeping Limited | Professional & scientific | 2005 |
| TH Mortgages Limited | Financial services | 2021 |
| Thaistyle Apparel Limited | Wholesale & retail | 2006 |
| THE Ambulance Museum Limited | Transport & logistics | 1991 |
| THE Balanced Artist Ltd | Extraterritorial | 2022 |
| THE Barber Shop (Barnstaple) Limited | Other services | 2003 |
| THE Blacksmith Collection Limited | Manufacturing | 2002 |
| THE Blue Pony Limited | Wholesale & retail | 2005 |
| THE Buckfastleigh Trust | Arts & recreation | 1998 |
| THE Byes 2001 Management Company Limited | Households | 2001 |
| THE Carly Press Limited | Manufacturing | 2003 |
| THE Cherub Inn Limited | Hospitality | 1997 |
| THE Chocolate Box | | 1991 |
| THE Cliff (Budleigh Salterton) Management Company Limited | Real estate | 2000 |
| THE Curtain and Soft Furnishings Workroom Ltd | Manufacturing | 2024 |
| THE Dartington North Devon Foundation | Health & social care | 1983 |
| THE Dartmouth Bakery Limited | Wholesale & retail | 2003 |
| THE Devon Bird of Prey and Wildlife Centre Limited | Arts & recreation | 2004 |
| THE Donkey Sanctuary | Other services | 2023 |
| THE Farm Commodity Brokers Limited | | 1998 |
| THE Foot Health Centre Limited | Health & social care | 2002 |
| THE Gearbox Company Limited | Wholesale & retail | 2003 |
| THE Ginger PIG HOG Roast and BBQ Company Ltd | Administrative & support | 2018 |
| THE Good Employability Company Ltd | Education | 2007 |
| THE Groom Room Newton Abbot Barber Ltd | Other services | 2017 |
| THE Hive MCB Limited | Administrative & support | 2025 |
| THE House of Cards (Tavistock) Limited | Wholesale & retail | 2005 |
| THE Information Network Limited | Information & communication | 2005 |
| THE JOB Shop Recruitment Service SW Ltd. | Administrative & support | 1999 |
| THE Kustomized Clothing Company Limited | Transport & logistics | 1997 |
| THE LEE Abbey Movement | Other services | 2002 |
| THE Lloyd Agency Limited | Professional & scientific | 1991 |
| THE Long Range Hotel Limited | Hospitality | 2003 |
| THE MAD Butcher of Winkleigh Ltd | Wholesale & retail | 2003 |
| THE Meadow Tennis Club Limited | Arts & recreation | 1996 |
| THE Mexican Ltd | Hospitality | 2001 |
| THE Moorings Residents Company Limited | Real estate | 1991 |
| THE Motorhouse Devonshire Limited | | 1982 |
| THE Movement Space Ltd | Other services | 2010 |
| THE Mulberry Collection Limited | Professional & scientific | 1987 |
| THE Parkview Management Company (Teignmouth) Limited | Households | 1998 |
| THE Plough Arts Centre Limited | Arts & recreation | 2002 |
| THE Plymouth International Marina Limited | Extraterritorial | 1997 |
| THE Plymouth Marina Limited | Extraterritorial | 1997 |
| THE Plymouth Yacht Marina Limited | Extraterritorial | 1997 |