| R. J. Beere Haulage Limited | Transport & logistics | 2003 |
| R. S Carpets and Furniture Limited | Wholesale & retail | 2002 |
| R.B.W. Developments Ltd. | Professional & scientific | 1998 |
| R.J. Hill (Haulage) Limited | Construction | 2002 |
| R.L. Pollard Limited | Construction | 2005 |
| R.T.B. Plumbing Limited | Construction | 2003 |
| R.U. Limited | Wholesale & retail | 1997 |
| R.Viney (Exeter) Limited | | 1963 |
| Racing Cobra Limited | Wholesale & retail | 2005 |
| Rackenford Community Shop C.I.C. | Wholesale & retail | 2002 |
| Raco Pvc-U Limited | Wholesale & retail | 2000 |
| Radford Plant & Haulage Limited | Transport & logistics | 2004 |
| Ramplan Ltd | Other services | 2023 |
| Rapid Holdings (SW) Limited | Construction | 2017 |
| Rapid Response Roofing and Building Ltd | Construction | 2025 |
| RAPIDM3 Limited | Information & communication | 2024 |
| Rateforce Limited | | 1984 |
| Rathbone Partnership Limited | Professional & scientific | 2006 |
| Ravenswood Estate Limited | Real estate | 1999 |
| RAY Stephens Ceilings & Partitions (UK) Limited | Wholesale & retail | 2002 |
| Raymond Potteries Limited | | 1962 |
| RC Property Investment SW Ltd | Real estate | 2025 |
| RDP Properties (Exmouth) Limited | Real estate | 1987 |
| React Water Services Limited | Construction | 2017 |
| Realigo Films Ltd | Information & communication | 2002 |
| Reblim Limited | Real estate | 2006 |
| Redrok Services Limited | Manufacturing | 2005 |
| Redwing Joinery Limited | Manufacturing | 2023 |
| Reed-Chill Cheater Limited | Wholesale & retail | 1999 |
| Regional Electricity (South West) Limited | | 1993 |
| Regirock Ltd. | Transport & logistics | 2014 |
| Releasure Limited | Professional & scientific | 2004 |
| Rescue South West Limited | | 1987 |
| Retreat Property Developments Limited | Extraterritorial | 2004 |
| Reynolds & Hill Refrigeration Limited | Professional & scientific | 2005 |
| Rhona Gillmore Limited | Wholesale & retail | 1991 |
| Richard Hayward & Company Limited | Professional & scientific | 1955 |
| Richard Walker Developments (Plymouth) Limited | Professional & scientific | 1999 |
| Richard Walker Developments Limited | Construction | 1997 |
| Richmil Consolidated Limited | Extraterritorial | 2007 |
| Richmond CNC Engineering (Devon) Limited | Manufacturing | 2004 |
| Richmond House (Exeter) Limited | Extraterritorial | 2001 |
| Rick Turner Management Ltd | Arts & recreation | 2002 |
| Ride World Wide Limited | Administrative & support | 1991 |
| Riding World Wide Limited | Extraterritorial | 2002 |
| RIG Systems Limited | Wholesale & retail | 2001 |
| Rigging Solutions Limited | Manufacturing | 2006 |
| River Dart Country Park Limited(The) | Hospitality | 1976 |
| River Height Views Limited | Professional & scientific | 2005 |
| River House Estates Limited | Construction | 2001 |
| Riverbend Holdings Ltd | Real estate | 2024 |
| Riverside Christian Centre | Other services | 2006 |
| Robert H Hicks Limited | Real estate | 2003 |
| Robinson Commercial Limited | Construction | 2001 |
| Roche Rentals Ltd | Real estate | 2022 |
| Rockford Recruitment Limited | Administrative & support | 2004 |
| Roger Underdown Limited | Construction | 2002 |
| Roly PIG Ltd | Wholesale & retail | 2003 |
| Roommaker Loft Conversions Ltd | | 1999 |
| Rota TUB Limited | Manufacturing | 2002 |
| Rotarosa Limited | Transport & logistics | 2007 |
| Rotisserie Queniart LA Ferme DE LA Vallee DE LA Canche Limited | Hospitality | 1998 |
| Royal Glen Hotel Limited | Hospitality | 2004 |
| Ruby Couture Limited | Wholesale & retail | 2003 |
| Rushymead Limited | Real estate | 2003 |
| Russell HAM Limited | Wholesale & retail | 2002 |
| Ryder Marketing Limited | Financial services | 2000 |
| S & L Holiday Park Services Ltd | Construction | 2006 |
| S & P Enterprises Limited | Real estate | 2003 |
| S and P Fish Limited | Agriculture & fishing | 2005 |
| S Cheers Agri Engineering Ltd | Manufacturing | 2015 |
| S G Barber Limited | Construction | 2004 |
| S J Flint Ltd | Construction | 2004 |
| S M W Haulage Limited | Transport & logistics | 1997 |
| S. & P. Trawlers (Jacaben) Limited | Agriculture & fishing | 1999 |
| S. & P. Trawlers Limited | Agriculture & fishing | 1999 |
| S.C. Hall Associates Limited | Professional & scientific | 2002 |
| S.D. Gibbens & Sons Ltd | Construction | 2006 |
| S.J. Dark Limited | Construction | 1980 |
| S.J. Sadler Limited | Construction | 1997 |
| S.L. Ogle & P.H. Wakeham | | 1994 |
| Sabre Hind Limited | Financial services | 2001 |
| Sabre Insurance Services Limited | Extraterritorial | 2007 |
| Safechange Property Management Limited | Professional & scientific | 1989 |
| Saleboards Limited | Real estate | 2006 |
| Salisbury House Management (Devon) Limited | Administrative & support | 1983 |
| SAM Widges Limited | Hospitality | 2005 |
| Sampsons Domestic Appliances Limited | Wholesale & retail | 2002 |
| Sanctuary of Sophia Ltd | Health & social care | 2023 |
| Sandbanks (Paignton) Management Limited | Households | 2007 |
| Sanders News Centre Limited | Wholesale & retail | 2003 |
| Sandgate Developments Limited | Construction | 2004 |
| Sands Road Framing Shop Limited | Wholesale & retail | 2002 |
| Sara Hilton Associates Limited | Professional & scientific | 2016 |
| Saunders Consultants Limited | Wholesale & retail | 1999 |
| SB Baker Feeds Limited | Agriculture & fishing | 2005 |
| SBS Maintenance Services Limited | Construction | 2007 |
| Scott Force 4 Limited | | 1988 |
| SCP Building Products Ltd | Wholesale & retail | 2022 |
| Scunthorpe Star Limited | Manufacturing | 1990 |