| Shivanshi Sharma Consultancy Ltd | Professional & scientific | 2022 |
| SHR Consulting Limited | Professional & scientific | 2024 |
| SHS Construction & Development Ltd | Construction | 2021 |
| Sierra Golf One Airsoft Ltd | Arts & recreation | 2022 |
| Signature Stone and Tile Limited | Construction | 2021 |
| Sika Properties Limited | Real estate | 2014 |
| Silbury Housing Holdings Limited | Construction | 2010 |
| Silbury Housing Limited | Construction | 2010 |
| Silbury Limited | Professional & scientific | 2018 |
| Silchester House School Limited | Real estate | 1967 |
| Silkwise Catering Limited | Hospitality | 2009 |
| Simon Lucas Bridge Supplies Limited | Wholesale & retail | 2006 |
| Sims & Co,(Builders)Limited | Construction | 1963 |
| Singing Surprise Limited | Arts & recreation | 2018 |
| Sitewise Engineering Ltd | Professional & scientific | 2011 |
| Skinning the Cat Limited | Professional & scientific | 2002 |
| Sleight Valley Golf Ltd | Arts & recreation | 2015 |
| Sloans Plumbing and Heating Limited | Construction | 2018 |
| Smart DEC Services Ltd | Construction | 2014 |
| Smart Fireworks Ltd | Arts & recreation | 2023 |
| Smart Green Shipping Alliance Limited | Professional & scientific | 2014 |
| Smart Kitchen Consulting Ltd | Professional & scientific | 2021 |
| Smart Management Limited | Information & communication | 1997 |
| Smart Pyrotechnics Ltd | Other services | 2012 |
| Snowden&Sons Ltd | Extraterritorial | 2007 |
| Snuff Street Limited | Real estate | 2018 |
| Soft Machine Limited | Information & communication | 2010 |
| Some Common Management Ltd | Arts & recreation | 2017 |
| Somerfords Fishing Club Limited | Real estate | 2025 |
| Sorted Direct Ltd | Transport & logistics | 2024 |
| Soupchick Ltd | Manufacturing | 2020 |
| South Coast Mile Builders Limited | Extraterritorial | 2020 |
| South West Amusements Limited | Arts & recreation | 2002 |
| South West DRY Lining Ltd | Construction | 2017 |
| South West Stump Removal Ltd | Agriculture & fishing | 2022 |
| Southern Hose & Hydraulics Ltd | Manufacturing | 2005 |
| Southern Training Services Ltd | Education | 2018 |
| SOW & Root Ltd | Arts & recreation | 2020 |
| Space Structures Ltd | Professional & scientific | 2013 |
| Spec-R Limited | Administrative & support | 2009 |
| Speedwell (Devizes) Limited | Real estate | 2001 |
| Splash - Wiltshire | Arts & recreation | 1995 |
| Spoonfed Ltd | Information & communication | 2025 |
| Sports Horse World Limited | Arts & recreation | 2007 |
| SRO Audiences Limited | Professional & scientific | 2004 |
| ST John's Mews (Devizes) Management Limited | Households | 2021 |
| ST Mary's Assembly Rooms Management Company Limited | Professional & scientific | 2007 |
| ST Mary's Road (M Lavington) Management Company Limited | Households | 2009 |
| ST. Eloy Ltd | Agriculture & fishing | 2026 |
| ST. John's Street Management Limited | Households | 1981 |
| ST. Mary Devizes Trust | Education | 2012 |
| Starwisher Limited | Professional & scientific | 2010 |
| Steele Davis Limited | Construction | 1992 |
| Steve Bull Specialist Cars (Sales) Ltd | Wholesale & retail | 2017 |
| Steve Bull Specialist Cars Limited | Wholesale & retail | 2003 |
| Steve Rumens Bricklaying and Stonework Contractors Limited | Construction | 2017 |
| Stokes Safety Consultancy Limited | Administrative & support | 2013 |
| Stonehenge Storage Solutions Ltd | Transport & logistics | 2019 |
| Storagebase Ltd | Transport & logistics | 2023 |
| Storyhouse Insights Limited | Information & communication | 2014 |
| Stove Hunters Limited | Wholesale & retail | 2019 |
| STP Retail Devizes Limited | Wholesale & retail | 2022 |
| Straker Capital Ltd | Financial services | 2025 |
| Straker Estate Agents Limited | Real estate | 2024 |
| Strakers (Devizes) Limited | Real estate | 1996 |
| Strakers (Holdings) Limited | Real estate | 2006 |
| Strategikons Ltd | Wholesale & retail | 2016 |
| Street Wise Pictures Limited | Information & communication | 2006 |
| Strongmind Resiliency Training Limited | Other services | 2014 |
| Stuckey Trading Ltd | Agriculture & fishing | 2026 |
| Suds & Snouts Ltd | Other services | 2025 |
| Survival Publishers Limited | Information & communication | 1982 |
| Survival Records Limited | Arts & recreation | 1982 |
| Sustainable YOU Ltd | Professional & scientific | 2021 |
| Swanborough Vehicle Maintenance Ltd | Wholesale & retail | 2018 |
| Swettenham Stud (2015) Limited | Agriculture & fishing | 2015 |
| SXW Carpentry Ltd | Manufacturing | 2015 |
| Symblism Ltd | Professional & scientific | 2024 |
| Symphony Online Limited | Information & communication | 2007 |
| Synergy Subsidiary Ltd | Professional & scientific | 2011 |
| T and P Hopkinson Ltd | Real estate | 2024 |
| T T Collins Consultancy Ltd | Professional & scientific | 2021 |
| T W Landscapes & Fencing Ltd | Administrative & support | 2010 |
| T. and S. T. Cuisine Limited | Hospitality | 2011 |
| T.D.S Garden Services Ltd | Administrative & support | 2018 |
| T.Y.M. Seals and Gaskets Limited | Manufacturing | 1993 |
| Tabono Ltd | Administrative & support | 2010 |
| Tacmed Ltd | Manufacturing | 2023 |
| Tailored Living Solutions Limited | Construction | 2012 |
| Tailored Workspace Solutions Limited | Real estate | 2021 |
| Tallyswood Ltd | Professional & scientific | 2021 |
| TAN Hill Ltd | Professional & scientific | 2022 |
| Tapps (Devizes) Ltd | Wholesale & retail | 2021 |
| Taurus Driver Hire Ltd | Other services | 2014 |
| Taylors OIL Services Ltd | Construction | 2025 |
| TCG Process Limited | Information & communication | 2022 |
| Tclr Property Investments Limited | Real estate | 2021 |
| Tcot Financial Services Limited | Financial services | 2015 |
| TD Lions Limited | Professional & scientific | 2017 |
| Team Success Ltd | Professional & scientific | 2012 |