| Savannah Systems Ltd | Information & communication | 2026 |
| Saver Packaging Limited | Wholesale & retail | 2025 |
| Savi Precision Engineering Ltd | Manufacturing | 2019 |
| Savoury Sausage Holdings Limited | Financial services | 2023 |
| Savoury Street Ltd | Hospitality | 2025 |
| Savshah Holdings Ltd | Financial services | 2026 |
| Savvygb Limited | Wholesale & retail | 2021 |
| Sawley Park Management Company Limited | Real estate | 2020 |
| Sawm Engineering Ltd | Construction | 2019 |
| Saxby Decor Limited | Construction | 2011 |
| Saxon Business & Accountancy Services Ltd | Professional & scientific | 2006 |
| Saxon Court Sinfin Management Co Ltd | Households | 2017 |
| Saxon Electrical Supplies Limited | Wholesale & retail | 2012 |
| Saxton Marketing Limited | Professional & scientific | 2014 |
| Sayf Drive Ltd | Transport & logistics | 2023 |
| Saymez Cars Limited | Wholesale & retail | 2020 |
| SB Building & Maintenance Limited | Professional & scientific | 2006 |
| SB Elec Ltd | Construction | 2010 |
| SB Promotions Limited | Wholesale & retail | 2018 |
| SB Records Limited | Wholesale & retail | 2020 |
| SB Web Consulting Ltd | Information & communication | 2010 |
| SBC Global Limited | Real estate | 2025 |
| SBI Accountants Ltd | Professional & scientific | 2023 |
| SBI Property Ltd | Real estate | 2025 |
| Sbmj Trade Ltd | Wholesale & retail | 2024 |
| SBS Commercial Property Limited | Real estate | 1992 |
| SBW Associates Limited | Other services | 2018 |
| SBW Property Solutions Ltd | Real estate | 2020 |
| SC & Co Holdings Ltd | Professional & scientific | 2019 |
| SC Audit and Assurance Services Limited | Professional & scientific | 2011 |
| SC Consultations Ltd | Education | 2020 |
| SC Health and Fitness Ltd | Arts & recreation | 2024 |
| SC Pro Connections Services Ltd | Education | 2019 |
| SC Storage Limited | Transport & logistics | 2025 |
| Sc&Ah Brickwork Ltd | Construction | 2025 |
| Sc&L Properties Ltd | Real estate | 2025 |
| Sc&Q Business Solutions Ltd | Professional & scientific | 2018 |
| Sc-Pjc LLP | | 2019 |
| SCA Limited | Real estate | 1983 |
| SCA Recruitment Limited | Professional & scientific | 1988 |
| Scaffnet Services Ltd | Construction | 2011 |
| Scale UP Property Group Ltd | Real estate | 2024 |
| Scalemaster Limited | Manufacturing | 1986 |
| Scalex Properties Ltd | Real estate | 2024 |
| Scallywags Nursery Limited | Health & social care | 2002 |
| Scarborough Avenue Skegness Ltd | Households | 2016 |
| Scargill Mann (Derby) Limited | Real estate | 2010 |
| Scargill Mann (Matlock) Limited | Real estate | 2002 |
| Scargill Mann Holdings Limited | Financial services | 2025 |
| Scargill Mann Residential Lettings Limited | Real estate | 1997 |
| Scarlett & Jaxon Hair Ltd | Other services | 2026 |
| Scate Limited | Professional & scientific | 2019 |
| Scenariio Ltd | Information & communication | 2013 |
| Scend Holdings Limited | Financial services | 2025 |
| Scenthra Ltd | Wholesale & retail | 2025 |
| Sceptre Aviation Ltd | Manufacturing | 2020 |
| SCG Design Ltd | Professional & scientific | 2021 |
| SCH Global Ltd. | Professional & scientific | 2025 |
| Schluck Ltd | Wholesale & retail | 2023 |
| Schofield Britten Limited | Professional & scientific | 2008 |
| Scholars Gate (Sunderland) Management Company Limited | Households | 2016 |
| Scholars Gate Management Company Limited | Households | 2010 |
| Scholars Place (Estcourt Close) Residents Management Company Limited | Households | 2018 |
| School of Arabic Ltd | Education | 2022 |
| School Transition Limited | Information & communication | 2020 |
| Schwartz & Mayer Market Equities Ltd | Real estate | 2025 |
| Scitek Consultants Limited | Professional & scientific | 1997 |
| SCM Sales Limited | Information & communication | 2019 |
| SCO Civil Engineering Ltd | Construction | 2024 |
| SCO Engineers Limited | Construction | 2026 |
| Scobas Limited | Professional & scientific | 2022 |
| Scoff Bespoke Cuisine Ltd | Hospitality | 2004 |
| Scoops (UK) LLP | | 2013 |
| Scoops Express (Chaddesden) Ltd | Hospitality | 2017 |
| Scoops Express (Derby) Ltd | Hospitality | 2016 |
| Scoops Group Ltd | Financial services | 2016 |
| Scope Engineering Limited | Professional & scientific | 2004 |
| Scope Finance Ltd | Professional & scientific | 2021 |
| Scope Kitchens and Bathrooms Ltd | Construction | 2013 |
| Scope Sync Solutions Limited | Construction | 2025 |
| Scorpion Positive Solutions Limited | Construction | 2008 |
| Scothern Vehicles Ltd | Wholesale & retail | 2022 |
| Scott Building Contractors Limited | Construction | 2020 |
| Scott Murray Limited | Financial services | 2005 |
| Scott the Gasman Ltd | Construction | 2020 |
| Scott Walters Guitar Tuition Limited | Education | 2013 |
| SCP Consultancy Ltd | Financial services | 2024 |
| Scream Enterprises Ltd | Hospitality | 2018 |
| Scrivens Consultancy Limited | Financial services | 2016 |
| Scrooge Limited | Construction | 2011 |
| Scropton Equestrian Centre Limited | Arts & recreation | 1999 |
| Scrubnation Smarthub Limited | Information & communication | 2026 |
| Scuba H2O Ltd | Education | 2022 |
| Sculpted Beauty Ltd | Other services | 2023 |
| Sculptura Aesthetics Ltd | Wholesale & retail | 2022 |
| Scyrotech Limited | Professional & scientific | 2022 |
| SD Actuarial Ltd | Information & communication | 2015 |
| SD Debts Collections Limited | Administrative & support | 2018 |
| SD Deliveries Ltd | Transport & logistics | 2025 |
| SD Digital Works Ltd | Wholesale & retail | 2020 |