| SA Short Holdings Ltd | Financial services | 2026 |
| SA Stores Limited | Wholesale & retail | 2025 |
| SAA Contracting Limited | Financial services | 2016 |
| SAA Intl Ltd | Wholesale & retail | 2019 |
| Saab Logistics Limited | Transport & logistics | 2024 |
| Saacit Ltd | Information & communication | 2015 |
| Saad Estates Limited | Real estate | 2022 |
| Saahi Properties Ltd | Real estate | 2019 |
| Saaras Technology Limited | Information & communication | 2025 |
| Saas Growth Coach Limited | Professional & scientific | 2022 |
| Sabaranis Ltd | Financial services | 2019 |
| Sabine Taverns Ltd | Hospitality | 2026 |
| Sabisu Ltd | Professional & scientific | 2024 |
| SABKICH13 Ltd | Real estate | 2019 |
| Sablemoore Limited | Professional & scientific | 2025 |
| Sabr & Haqq Ltd | Wholesale & retail | 2026 |
| Sabri Gazail Limited | Professional & scientific | 2026 |
| Sachimoto Limited | Professional & scientific | 2024 |
| Sacred Bean Coffee CIC | Wholesale & retail | 2019 |
| Sadaf Mehroof Ltd | Health & social care | 2021 |
| Saddlers Chase Residents Management Company Limited | Households | 2025 |
| Saddlers Fish & Chips (Derby) Limited | Hospitality | 2021 |
| Sade.J Homes Ltd | Real estate | 2024 |
| SAF Mixed Martial Arts Ltd | Education | 2025 |
| Safa Catering Ltd | Hospitality | 2025 |
| Safaai Ltd | Administrative & support | 2025 |
| Safe & Secure Insurance Services Limited | Financial services | 2001 |
| Safe & Sound Broadcast Ltd | Information & communication | 2020 |
| Safe and Sound Group | Other services | 2002 |
| Safe Financials Holdings Ltd | Information & communication | 2024 |
| Safe Financials Limited | Information & communication | 1999 |
| Safe Hands Interpreting Limited | Other services | 2009 |
| Safe Hands Sales Ltd | Professional & scientific | 2026 |
| Safe Heating Solutions Ltd | Construction | 2022 |
| Safe Homes GAS Solutions Ltd | Construction | 2023 |
| Safepharm Consultants Ltd | Professional & scientific | 2018 |
| Safer Plumbing & Heating Ltd | Construction | 2025 |
| Safety Choice Health & Safety Consultancy Limited | Administrative & support | 2000 |
| Safety Rules Training Ltd | Public administration | 2022 |
| Safety Signs and Notices Ltd | Manufacturing | 2013 |
| Saffron (Eco) Ltd | Agriculture & fishing | 2021 |
| Safi Deliveries Ltd | Transport & logistics | 2025 |
| Safsal Ltd | Wholesale & retail | 2025 |
| Safyrr Propulsion Limited | Extraterritorial | 2001 |
| SAG New Talent Ltd | Administrative & support | 2025 |
| Sage Chameleon Properties Ltd | Real estate | 2026 |
| Sage Short Stays Ltd | Real estate | 2024 |
| Sagfield Cleaning Services Ltd | Administrative & support | 2024 |
| Sagitta Automotive Limited | Wholesale & retail | 2008 |
| Sagroz Ltd | Hospitality | 2021 |
| Sahahra | Health & social care | 2001 |
| Sahara Healthcare Ltd | Health & social care | 2023 |
| Sahib Business Solutions Ltd | Professional & scientific | 2014 |
| Sahota Homes Ltd | Real estate | 2025 |
| Sahota Property Group Ltd | Real estate | 2021 |
| Sahota Property Investments Limited | Construction | 2026 |
| Sahota Services Ltd | Other services | 2018 |
| Sahota-Parekh Properties Ltd | Real estate | 2023 |
| SAI Nova Ltd | Wholesale & retail | 2024 |
| Saif Auto Derby Limited | Wholesale & retail | 2024 |
| Saif Travel Ltd | Transport & logistics | 2026 |
| Saif's Grill Ltd | Hospitality | 2018 |
| Saini Bros Haulage Ltd | Transport & logistics | 2023 |
| Saini Transport Ltd | Transport & logistics | 2016 |
| Saint George's Enterprises Ltd | Real estate | 2020 |
| Saint Property Services Ltd | Real estate | 2007 |
| Sair Fastfood Ltd | Hospitality | 2025 |
| Sair Group of Companies Ltd | Hospitality | 2025 |
| Sajaab Farms UK Ltd | Wholesale & retail | 2018 |
| Sala Car Sales Ltd | Wholesale & retail | 2025 |
| Salador Company Ltd | Wholesale & retail | 2010 |
| Salahuddin Projects Ltd | Real estate | 2026 |
| Salam Travel and Tours Limited | Administrative & support | 2025 |
| Salauddin Ltd | Other services | 2023 |
| Salesade Limited | Professional & scientific | 2020 |
| Salgados Limited | Hospitality | 2018 |
| Salloway Property Consultants Limited | Real estate | 2014 |
| Sally Botham Estates Limited | Real estate | 2003 |
| Sallys Pitstop Ltd | Wholesale & retail | 2025 |
| Salma Solutions Ltd | Information & communication | 2016 |
| Salt Network Consulting Limited | Information & communication | 2005 |
| SALT4 Limited | Construction | 2023 |
| Salty Goods Ltd | Hospitality | 2024 |
| Salubrity Health Ltd | Health & social care | 2024 |
| Salus Medical Solutions Ltd | Health & social care | 2024 |
| Salvus Causa Ltd | Professional & scientific | 2012 |
| Salvus Business Solutions Limited | Professional & scientific | 2023 |
| SAM Murton Limited | Administrative & support | 2023 |
| SAM Randon Racing Limited | Arts & recreation | 2014 |
| SAM Reed Limited | Professional & scientific | 2008 |
| SAM Taylor Utility Services Limited | Manufacturing | 2013 |
| Sam&Mo Fabricatons Ltd | Manufacturing | 2026 |
| Sam's Autos Ltd | Wholesale & retail | 2017 |
| SAM1 Services UK Ltd | Wholesale & retail | 2015 |
| Samadhi Meditation Center Derby CIC | Other services | 2025 |
| Samagi Motor Car Limited | Wholesale & retail | 2023 |
| Samba Simba Safari Tours Ltd | Administrative & support | 2015 |
| Sambahr Ltd | Administrative & support | 2018 |
| Samgee Limited | Financial services | 2017 |
| Sami Tipi Limited | Administrative & support | 2012 |