| Reiju Ltd | Manufacturing | 2014 |
| Reilly Leisure Public Limited Company | Hospitality | 1994 |
| Rein Enterprises Ltd | Real estate | 2014 |
| Reinvention Fitness Derby Limited | Arts & recreation | 2016 |
| Reinvention Security Limited | Administrative & support | 2023 |
| Rekoh Limited | Construction | 1989 |
| Relate 24/7 Care Ltd | Health & social care | 2022 |
| Relate Wellness Ltd | Health & social care | 2023 |
| Relationships Derby Ltd | Health & social care | 2003 |
| Relax Derby Ltd | Health & social care | 2025 |
| Releaseops Solutions Limited | Information & communication | 2026 |
| Reliance Accounting Limited | Professional & scientific | 2018 |
| Reliant 365 Ltd | Health & social care | 2020 |
| Reliant Financial Services Ltd | Financial services | 2023 |
| Reliant Total Facilities Management Ltd | Administrative & support | 2024 |
| Relu Ltd | Construction | 2018 |
| Remarkable Practice Ltd | Professional & scientific | 1997 |
| Rembanx Limited | Professional & scientific | 2025 |
| Rembrace Ltd | Information & communication | 2015 |
| Remedis Spiced Drinks Ltd | Manufacturing | 2026 |
| Remmiget Limited | Transport & logistics | 2021 |
| Remote Roost Limited | Professional & scientific | 2021 |
| Remoting Ltd | Information & communication | 2024 |
| Remus Painting Color Limited | Construction | 2024 |
| Remusb Limited | Manufacturing | 2020 |
| REN Trading Ltd | Hospitality | 2019 |
| Renaissance Hair Salon U.K Ltd | Other services | 2023 |
| Renda Limited | Professional & scientific | 2019 |
| Rendacious Records Limited | Information & communication | 2021 |
| Rendezvous (Derby) Limited | Wholesale & retail | 2004 |
| Renegade Performance Ltd | Wholesale & retail | 2019 |
| Renewable Heat (UK) Ltd | Construction | 2010 |
| Renix (UK) Limited | Transport & logistics | 2013 |
| Renorama Construction Ltd | Construction | 2019 |
| Renos Electric Ltd | Construction | 2020 |
| Renova Homes Group Limited | Real estate | 2024 |
| Renovation Kings Midlands Ltd | Construction | 2019 |
| Renovatr Ltd | Construction | 2021 |
| Rent House Derby Limited | Real estate | 2017 |
| Rent to Rent Education Ltd | Education | 2022 |
| RENT4U Property Ltd | Real estate | 2024 |
| Rental Realm Ltd | Real estate | 2026 |
| Rentli Ltd | Real estate | 2024 |
| Rentwise Property Solutions Ltd | Households | 2024 |
| Renvor Ltd | Wholesale & retail | 2026 |
| REP Properties Limited | Real estate | 2025 |
| Repairmymeterbox Limited | Other services | 2020 |
| Repetitive Beats Ltd | Information & communication | 2025 |
| Replenish & Restore Ltd | Hospitality | 2024 |
| Replication Systems Ltd | Information & communication | 2019 |
| Repmac Limited | Wholesale & retail | 2023 |
| Reptilian Republic Ltd | Wholesale & retail | 2023 |
| Repton Development Company Limited | Construction | 2006 |
| Repton Lettings Limited | Real estate | 2024 |
| Repton Personal Training Ltd | Other services | 2021 |
| Repton Security Limited | Administrative & support | 2004 |
| Reputable Rendering Ltd | Construction | 2022 |
| Resail UK Limited | Wholesale & retail | 2025 |
| Research Standard Index Limited | Professional & scientific | 2019 |
| Research Well Limited | Professional & scientific | 2024 |
| Reset 26 Limited | Real estate | 2026 |
| Reset Focus Holdings Limited | Financial services | 2026 |
| Reset Focus Ltd | Other services | 2021 |
| Reset Real Estate Limited | Professional & scientific | 2023 |
| Residual-Ai Ltd | Professional & scientific | 2026 |
| Resihaus Limited | Real estate | 2025 |
| Resilient Supplies Ltd | Wholesale & retail | 2024 |
| Resin Driveway Professionals Ltd | Construction | 2019 |
| Resin Style Driveways Limited | Administrative & support | 2016 |
| Resoda Projects Limited | Education | 2009 |
| Resolute One Limited | Wholesale & retail | 2010 |
| Resolution Computing Limited | Information & communication | 2007 |
| Resolution Property Ventures Ltd | Professional & scientific | 2021 |
| Resolve Solutions (Midlands) Limited | Professional & scientific | 2006 |
| Resonate Group Limited | Information & communication | 2006 |
| Resonate Holdings Limited | Professional & scientific | 2006 |
| Resonate Newco 4 Limited | Professional & scientific | 2006 |
| Resonate Newco 5 Limited | Professional & scientific | 2006 |
| Resonate Notified Body Limited | Extraterritorial | 1998 |
| Resort Development and Construction Services Limited | Construction | 2014 |
| Respect Collaboration Trust | Education | 2025 |
| Response Property Management Ltd | Other services | 2023 |
| Response Property Services Ltd | Other services | 2019 |
| Restart Group Limited | Education | 2025 |
| RESTAURANTONE20 Limited | Hospitality | 2021 |
| Restore a Roof (UK) Ltd | Construction | 2013 |
| Restore a Roof With TLC Ltd | Construction | 2020 |
| Restoreo International Ltd | Professional & scientific | 2025 |
| Restoreo Surface Repairs Limited | Construction | 2019 |
| Results Personal Training Limited | Other services | 2012 |
| Results Property Management Limited | Real estate | 2013 |
| Results.World Ltd | Wholesale & retail | 2026 |
| Resurrection Construction Limited | Construction | 2010 |
| Resurrection Properties Limited | Real estate | 2007 |
| Retagged Warehouse Limited | Professional & scientific | 2021 |
| Retail Assist Limited | Information & communication | 1999 |
| Retail Development Projects Limited | Construction | 2011 |
| RETAIL247 Consulting Limited | Administrative & support | 2014 |
| Rethinking Property Limited | Real estate | 2023 |
| Retina Care Ltd | Health & social care | 2011 |