| Pine Tree Property Management Company Limited | Real estate | 2010 |
| Pinve Ltd | Households | 2025 |
| Plumbchum South West Ltd | Construction | 2025 |
| Premier First Plastering Ltd | Construction | 2019 |
| Proggen Core Ltd | Information & communication | 2026 |
| Proggen Holdings Ltd | Financial services | 2026 |
| Proggen Ltd | Professional & scientific | 2025 |
| Promenade Promotions (Prom Prom) | Arts & recreation | 2003 |
| Purple Swan Ltd | Wholesale & retail | 2013 |
| Purple Swan Relocations Ltd | Hospitality | 2020 |
| Q10 Financial Services Limited | Financial services | 2018 |
| Qwerty Automotive Ltd | Wholesale & retail | 2025 |
| R D Johns Properties (2020) Ltd | Real estate | 2019 |
| R7M Group Holdings Limited | Financial services | 2024 |
| Ramsay Maunder Associates Limited | Information & communication | 2009 |
| Ravus Construction Ltd | Construction | 2025 |
| Rawe Ltd | Other services | 2024 |
| Red Doors International Services BV Ltd | Information & communication | 2013 |
| Red Rock Electrical Limited | Construction | 2005 |
| Red Rock EOT Limited | Administrative & support | 2024 |
| Red Rock Property (SW) Limited | Real estate | 2012 |
| Redmine Solutions Limited | Extraterritorial | 2015 |
| Redrock Entertainment Ltd | Arts & recreation | 2020 |
| Reflections South West Limited | Hospitality | 2015 |
| Retail Business Support Solutions Ltd | Professional & scientific | 2020 |
| Richard Foran Ltd | Professional & scientific | 2025 |
| Richard Williams Classic Minis Limited | Wholesale & retail | 2009 |
| RIDE2B Ltd | Wholesale & retail | 2020 |
| Robust Entertainment Ltd | Information & communication | 2025 |
| Rockview Group Ltd | Financial services | 2025 |
| Rossmore Accountants Limited | Professional & scientific | 2022 |
| RR Kitchens (SW) Ltd | Wholesale & retail | 2025 |
| Run My Payroll Ltd | Administrative & support | 2021 |
| S & G Machinery Ltd | Manufacturing | 2005 |
| S Class Lettings Limited | Wholesale & retail | 2025 |
| SAM Gilroy Arts Ltd | Arts & recreation | 2025 |
| Sandstone Property Services Ltd | Construction | 2025 |
| Sara 24/7 Trading Limited | Wholesale & retail | 2025 |
| SARA24 Limited | Real estate | 2025 |
| Sarah J Payne Ltd | Professional & scientific | 2026 |
| Sarah Jones Pilates Ltd | Arts & recreation | 2014 |
| SB Connected Limited | Arts & recreation | 2018 |
| Schoey Ltd | Professional & scientific | 2024 |
| Screech & Screech Limited | Transport & logistics | 2017 |
| SCY Builders Limited | Construction | 2025 |
| Sealand Electrical Ltd. | Extraterritorial | 2013 |
| SF Roofing and Cladding Services Limited | Construction | 2024 |
| SG & JG Limited | Other services | 2005 |
| SGC Group Ltd | Construction | 2019 |
| Shepherd Shack Limited | Hospitality | 2022 |
| Shivab Ltd | Construction | 2026 |
| Shooters (Dawlish) Ltd | Hospitality | 2021 |
| Signature Property Management SW Ltd | Real estate | 2022 |
| Simply Care Devon Ltd | Health & social care | 2023 |
| Sira Construction Limited | | 1999 |
| SM Contractors South West Ltd | Manufacturing | 2023 |
| SM Engineering South West Ltd | Manufacturing | 2018 |
| SM Equipment & Services Ltd | Administrative & support | 2024 |
| SM Properties South West Ltd | Real estate | 2024 |
| Small Business Support Solutions Ltd | Information & communication | 2020 |
| South West Agencies Limited | Other services | 2005 |
| South West Drywall Limited | Construction | 2005 |
| South West Tools Ltd | Wholesale & retail | 2020 |
| Southern Healthcare (Wessex) Ltd | Health & social care | 2001 |
| Southern Healthcare Properties Limited | Real estate | 2021 |
| Southern Ventures Enterprise LLP | | 2024 |
| Southern Ventures Group Ltd | Wholesale & retail | 2024 |
| Southern Ventures Ltd | Education | 2019 |
| Southernhay Cleaners (SW) Limited | Administrative & support | 2003 |
| Southwest Estates Group Limited | Real estate | 2022 |
| Southwest Residential Holdings Limited | Real estate | 2022 |
| Sovereign Credits Ltd | Arts & recreation | 2022 |
| Space Scaffolding Ltd | Construction | 2017 |
| Speed Software Ltd. | Information & communication | 1999 |
| Spencer Charles Ltd | Professional & scientific | 2019 |
| SPF Consult Ltd | Education | 2026 |
| Splat Attack CIC | Arts & recreation | 2021 |
| Sporty Stars Plymouth Ltd | Arts & recreation | 2025 |
| St.Thomas Garments Limited | Wholesale & retail | 2025 |
| Stamped in Tradition Ltd | Administrative & support | 2025 |
| Star Marine Photographic Adventures Ltd | Professional & scientific | 2026 |
| Start UP Business Support Solutions Ltd | Information & communication | 2020 |
| STB Carpentry and Maintenance Limited | Manufacturing | 2014 |
| Storm Crowd Management Ltd | Administrative & support | 2022 |
| Strand Community Trust Ltd | Health & social care | 2008 |
| Stratos Executive Protection Ltd | Administrative & support | 2025 |
| Stuart Gray Maintenance Ltd | Construction | 2019 |
| Sun & Sound Limited | Arts & recreation | 2025 |
| Surrey Parks Limited | Hospitality | 2021 |
| SW Business Support Solutions Ltd | Professional & scientific | 2018 |
| Swan Holidays Ltd | Hospitality | 1927 |
| Switched on Technology Limited | Wholesale & retail | 2008 |
| T.E.K Holding SW Ltd | Manufacturing | 2025 |
| TC Upshall Limited | Construction | 2003 |
| TDR Property Services Limited | Real estate | 2003 |
| Tebbit Properties Limited | Real estate | 2020 |
| Teign View Veterinary Practice Limited | Professional & scientific | 2002 |
| Teignmouth Maritime Properties Limited | Transport & logistics | 2018 |
| Teignmouth Maritime Services (Plant) Limited | Administrative & support | 2021 |
| Teignmouth Maritime Services Limited | Construction | 2002 |