| Debbie & Tom's Cleaning Services Limited | Administrative & support | 2020 |
| Debbie Burbage Limited | Administrative & support | 2010 |
| Debbie COX Limited | Real estate | 2024 |
| Decisive Moments Ltd | Information & communication | 2024 |
| Decowithstyle Ltd | Construction | 2020 |
| Deddington Liquid Waste Disposal Limited | Water & waste | 2008 |
| DEF Property Limited | Real estate | 2017 |
| Definitive Machine Services Ltd | Manufacturing | 2020 |
| Deiz Electrical Ltd | Construction | 2023 |
| Deiz Group Limited | Transport & logistics | 2025 |
| DEL Construct Ltd | Construction | 2021 |
| Delicious Fries LLP | | 2020 |
| Delicious Fries Global Ltd | Manufacturing | 2024 |
| Delis Bar Limited | Hospitality | 2024 |
| Deltar Group Ltd | Construction | 2022 |
| Delux Trans Ltd | Transport & logistics | 2024 |
| Delyth Bending Accountancy Limited | Professional & scientific | 2006 |
| Demeter Housing Limited | Real estate | 2019 |
| Department 28 Limited | Administrative & support | 2023 |
| Derma Edit Clinic Limited | Health & social care | 2025 |
| DES Property Maintenance Ltd | Construction | 2017 |
| Design and Engineering Solutions Limited | Wholesale & retail | 2012 |
| Development Business (UK) Ltd | Professional & scientific | 2006 |
| Devereux Holdings Ltd | Extraterritorial | 2024 |
| Devine-Pemberton Bloodstock Ltd | Arts & recreation | 2024 |
| Dextra Inc Ltd | Manufacturing | 2020 |
| DFD Lettings Ltd | Real estate | 2020 |
| DI Plumbing and Maintenance Ltd | Construction | 2025 |
| Diaken Healthcare Services Ltd | Health & social care | 2025 |
| Diesel Energy Limited | Manufacturing | 2019 |
| Digital Capture Ltd | Wholesale & retail | 2025 |
| Digital Lift Controls Limited | Extraterritorial | 2016 |
| Digital Photo Gallery Limited | Information & communication | 2010 |
| Dinamika 58 Ltd | Transport & logistics | 2020 |
| Dino 21 Ltd | Hospitality | 2024 |
| Direct Funding Associates Limited | Professional & scientific | 2003 |
| Direct Selling Association Limited(The) | Other services | 1965 |
| Direkt Trans Ltd | Transport & logistics | 2023 |
| Disconnect Clothing Limited | Wholesale & retail | 2011 |
| Diva Spedition Limited | Transport & logistics | 2020 |
| DJB Networks Limited | Information & communication | 2017 |
| DJT Property Services Ltd | Construction | 2022 |
| Dlem Limited | Transport & logistics | 2025 |
| DMH Testing Holdings Limited | Financial services | 2025 |
| DMH Testing Limited | Construction | 2021 |
| DMW UK Limited | Wholesale & retail | 2006 |
| Doepke UK Ltd | Manufacturing | 1974 |
| Dofured Group Co., Limited | Wholesale & retail | 2020 |
| Dogs Life Ltd | Wholesale & retail | 2024 |
| Dolphin Day Nursery Limited | Health & social care | 2006 |
| Domikor Limited | Wholesale & retail | 2024 |
| Doodle and Pips Limited | Wholesale & retail | 2025 |
| Dosuccess Ltd | Health & social care | 2018 |
| Dotty HEN Wholesale Limited | Wholesale & retail | 2015 |
| Doves Funeral Directors Limited | Other services | 2017 |
| Dowd Properties Ltd | Real estate | 2021 |
| DPH Consultancy Limited | Education | 2019 |
| DPW Plumbing and Heating Limited | Construction | 2017 |
| DR Lauren Patton Psychological Therapy and Consultation Ltd | Health & social care | 2025 |
| DR Loki Ltd | Health & social care | 2023 |
| Dragon Design Services Limited | Administrative & support | 2003 |
| Dragons Dents Ltd | Wholesale & retail | 2017 |
| Drain Buddy Solutions Ltd | Water & waste | 2023 |
| Drinkwater Ltd | Transport & logistics | 2018 |
| Drive Connection Ltd | Transport & logistics | 2025 |
| Driveado Ltd | Transport & logistics | 2014 |
| Drivenex Solutions Ltd | Information & communication | 2025 |
| Dscpmproperties Ltd | Real estate | 2025 |
| DSD Transport Ltd | Transport & logistics | 2026 |
| DSK Energy Ltd | Professional & scientific | 2024 |
| Dsurman-Driving Ltd | Transport & logistics | 2025 |
| Dtfc 1886 Ltd | Education | 2018 |
| Ducktive Ltd | Professional & scientific | 2010 |
| Dudgeons Trading Limited | Hospitality | 2023 |
| Duncan Clare Limited | Construction | 2010 |
| Dvlc Limited | Transport & logistics | 2024 |
| DYP Associates Ltd | Administrative & support | 2011 |
| E M Pell & Partners Limited | Agriculture & fishing | 2012 |
| E M Pell & Partners Properties Limited | Real estate | 2016 |
| E&E Plumbing Ltd | Construction | 2025 |
| E-Commerce Directory Limited | Information & communication | 2025 |
| E-Fuka Technologies Ltd | Manufacturing | 2020 |
| E.B.H Wiring Solutions Ltd | Manufacturing | 2024 |
| E2E Monitoring Limited | Information & communication | 2012 |
| Early Doors Daventry Ltd | Hospitality | 2019 |
| Early Years Film Studios Ltd | Professional & scientific | 2023 |
| Easi Group Limited | Other services | 2019 |
| East Midlands Consulting Limited | Extraterritorial | 2009 |
| Eastway Import Limited | Wholesale & retail | 2024 |
| EB Bothand Limited | Professional & scientific | 2019 |
| Eclipse Sportscars Limited | Professional & scientific | 2008 |
| Eco Elec Engineers Limited | Construction | 2014 |
| Ecodryenergy Limited | Manufacturing | 2014 |
| Ecosail Environmental Technology Group UK Limited | Manufacturing | 2020 |
| Ecotherm Facilities Limited | Construction | 2023 |
| Ecotherm Stoves Limited | Construction | 2024 |
| Edenwich Limited | Professional & scientific | 2016 |
| Edipan Trans Ltd | Administrative & support | 2018 |
| Educationsupport Limited | Education | 2024 |
| EIGHT8 Ventures Ltd | Wholesale & retail | 2026 |