| Remdog Utilities Ltd | Construction | 2024 |
| Renolux Property Group Ltd | Construction | 2025 |
| Resin Install Limited | Construction | 2017 |
| Response Care Ltd | Health & social care | 2025 |
| Retreat Trading Limited | Wholesale & retail | 2024 |
| Retro Restos Ltd | Wholesale & retail | 2020 |
| Reza SPM Limited | Other services | 2024 |
| RH Joinery (NW) Ltd | Construction | 2026 |
| Ribble Car Sales Ltd | Wholesale & retail | 2024 |
| Ribble Valley Balloons Ltd | Professional & scientific | 2025 |
| Ribble Valley GP Services Ltd | Health & social care | 2022 |
| Ribble Valley Tennis Centre Limited | Arts & recreation | 1987 |
| Richard Haynes Limited | Health & social care | 2003 |
| Richard Kerr Limited | Health & social care | 1956 |
| Richmont Holdings Limited | Construction | 2025 |
| Rick Stock Ltd | Transport & logistics | 2018 |
| Right Carperts Darwen Limited | Wholesale & retail | 2022 |
| Rightgrass Limited | Administrative & support | 2015 |
| Ringway Ltd | Real estate | 2021 |
| Riverside Wood Products Ltd | Manufacturing | 2014 |
| RKF Installations Ltd | Construction | 2026 |
| RKH Finishes Limited | Construction | 2016 |
| RKL Holdings Limited | Wholesale & retail | 2015 |
| Rlab Holdings Ltd | Financial services | 2025 |
| Rlab Properties Ltd | Real estate | 2025 |
| Rlab Technologies Ltd | Information & communication | 2025 |
| RMC Property Maintenance Ltd | Construction | 2019 |
| RMG Couriers Ltd | Transport & logistics | 2024 |
| RN Entertainment Ltd | Arts & recreation | 2022 |
| RN Upholstery Limited | Other services | 2012 |
| Robert Soutar Limited | Professional & scientific | 1987 |
| Rock Inn PUB and Restaurant Ltd | Hospitality | 2026 |
| Roebuck Masonry Ltd | Construction | 2022 |
| Roger LEE Optometrists Limited | Health & social care | 2007 |
| Roman Road Centurions FC Ltd | Arts & recreation | 2024 |
| Ronset Holdings Limited | Professional & scientific | 2008 |
| Room Filler Ltd | Professional & scientific | 2023 |
| Roosters Express Chicken Ltd | Hospitality | 2015 |
| Rosa Hearing Ltd | Wholesale & retail | 2022 |
| Rose & MAY Homes Ltd | Construction | 2025 |
| Rose Plumbing and Heating Limited | Construction | 2016 |
| Rosso Group Ltd | Wholesale & retail | 2019 |
| Rothwell Arts Entertainment LP | | 2025 |
| ROUTE2RECRUIT Ltd | Administrative & support | 2023 |
| Routledge & Co Ltd | Professional & scientific | 2024 |
| Rowley Place Management Company Ltd | Other services | 2020 |
| Rowley Place Revival Limited | Other services | 2022 |
| Roxby Hseq Risk Solutions Ltd | Professional & scientific | 2015 |
| Rubberduck Group Ltd | Information & communication | 2020 |
| Rucca Holdings Limited | Manufacturing | 2010 |
| Rushton's the Bacon Stall Ltd | Hospitality | 2012 |
| Rushtons of Darwen Ltd | Hospitality | 2023 |
| Russkell Upholstery Holdings Limited | Financial services | 2025 |
| Russlee Properties Limited | Real estate | 2004 |
| RVN Gearboxes Ltd | Professional & scientific | 2024 |
| RWB Knowles Holdings Ltd | Real estate | 2021 |
| Ryan Anderson Limited | Arts & recreation | 2018 |
| S & a Drylining North West Limited | Construction | 2019 |
| S & C Developments Limited | Construction | 2002 |
| S & H Investments (Blackburn) Limited | Manufacturing | 2019 |
| S & H Maintenance Limited | Construction | 2015 |
| S Donne (Bedford) Limited | Health & social care | 1991 |
| S Vintage Ltd | Hospitality | 2025 |
| S&H Group Limited | Extraterritorial | 2016 |
| S. J. F. Electrics Limited | Construction | 2003 |
| S.P.Removals Ltd | Transport & logistics | 2025 |
| S.W. Barradell Limited | Wholesale & retail | 1977 |
| Saaz Holdings Ltd | Real estate | 2019 |
| SAB Science Ltd | Professional & scientific | 2024 |
| Sadiyah EYE Specialist Ltd | Health & social care | 2022 |
| Safco Limited | Real estate | 2020 |
| Safe and Insured Limited | Extraterritorial | 2016 |
| Safety Works Global Ltd | Administrative & support | 2021 |
| Sakura Bidco Limited | Financial services | 2025 |
| Sakura Holdco Limited | Financial services | 2025 |
| Sakura Midco Limited | Financial services | 2025 |
| Salam Community Schooling CIC | Education | 2026 |
| Sales Bridge Services Ltd | Wholesale & retail | 2026 |
| Sally's Homeschool Support Ltd. | Other services | 2024 |
| Salvare Ltd | Information & communication | 2023 |
| SAM666 Ltd | Wholesale & retail | 2025 |
| SAMI333 Ltd | Wholesale & retail | 2025 |
| SAMPLES2GO Ltd | Manufacturing | 2024 |
| SAN Enforcement Limited | Professional & scientific | 2018 |
| SAN Remo Pizza House Ltd | Hospitality | 2023 |
| Sanderling Walk Management Company Limited | Other services | 2021 |
| Sarah Dineen Limited | Wholesale & retail | 2011 |
| Sarah Etherington Consulting Ltd | Information & communication | 2025 |
| Sarah Lowry Ltd | Health & social care | 2005 |
| Satellite and Terrestrial Works Ltd | Professional & scientific | 2014 |
| Satti’S Periperi Ltd | Hospitality | 2023 |
| Sbecdol CYF | Wholesale & retail | 2022 |
| Sbhn Fast Food Ltd | Hospitality | 2025 |
| SC Medical Aesthetics Ltd | Health & social care | 2025 |
| SC Roofing & Paving Ltd | Construction | 2023 |
| Scher & Lasky Opticians Ltd | Wholesale & retail | 2002 |
| Schofield Hairdressing Ltd | Other services | 2018 |
| Scorpius Security NW Ltd | Administrative & support | 2021 |
| Screenco Digital Signage Ltd | Professional & scientific | 2016 |
| Scutum North Limited | Construction | 2003 |