| Sabe Property Ltd | Real estate | 2021 |
| Sabeez WSM PVT Ltd | Hospitality | 2020 |
| Sabmic Limited | Professional & scientific | 2017 |
| Sabzii Limited | Wholesale & retail | 2026 |
| Sadler Fogarty Services Ltd. | Professional & scientific | 2010 |
| Saess Limited | Health & social care | 2015 |
| Safe & Sound Securities Limited | Administrative & support | 2003 |
| Safe Homes S.E Limited | Real estate | 2017 |
| Safe Space Living Limited | Real estate | 2022 |
| Safe-Shred UK Ltd | Extraterritorial | 2010 |
| Safefix Property Maintenance Ltd | Construction | 2018 |
| Safeharbour Living Ltd | Health & social care | 2026 |
| Safeline Group UK Limited | Administrative & support | 2018 |
| Safer Solar UK Limited | Construction | 2020 |
| Safetell Limited | Manufacturing | 1989 |
| Saga Security Services Limited | Administrative & support | 2021 |
| Sage Controls Ltd | Construction | 2019 |
| Sahara Global Synergy Ltd | Information & communication | 2025 |
| Saharsh Properties Limited | Real estate | 2024 |
| Saharsh Software Limited | Information & communication | 2016 |
| SAI GK Limited | Real estate | 2023 |
| SAI Gkpr Limited | Real estate | 2024 |
| SAI RP Limited | Real estate | 2024 |
| SAI Rpgk Limited | Real estate | 2023 |
| Saijury Limited | Information & communication | 2017 |
| Saim Learn & Play Ltd | Arts & recreation | 2023 |
| Saimourya Info Solutions Limited | Information & communication | 2022 |
| Saint JAY Marketing Ltd | Professional & scientific | 2021 |
| Sajswe Consultancy Limited | Administrative & support | 2026 |
| SAK Food Services Limited | Hospitality | 2024 |
| SAK IT Solutions Ltd | Information & communication | 2019 |
| Saket Surgical Ltd. | Health & social care | 2016 |
| Sakinah Ltd | Real estate | 2022 |
| Salamander Limited | Administrative & support | 2005 |
| Sales Consultants (Kent) Limited | Real estate | 2022 |
| Sales Consultants (London) Limited | Professional & scientific | 2020 |
| Sally Sues Limited | Hospitality | 2022 |
| Salon 167 Hair & Beauty Ltd | Other services | 2017 |
| Salpa Consulting Ltd | Professional & scientific | 2018 |
| Saltburn Limited | Construction | 2025 |
| Saltiee Ltd | Health & social care | 2026 |
| Salus Psychological Services Limited | Health & social care | 2014 |
| Salvatore Allegro Construction Limited | Construction | 2018 |
| Salvo International Ltd | Real estate | 2024 |
| SAM & HO Investment Company Limited | Real estate | 1993 |
| SAM Estate Management UK Limited | Real estate | 2022 |
| SAM Infotech Ltd | Information & communication | 2017 |
| Samac Business Solutions Ltd | Financial services | 2019 |
| Samantha Taylor Photography Ltd | Professional & scientific | 2013 |
| Samapex Construction Ltd | Construction | 2024 |
| Samapex Property Ltd | Real estate | 2025 |
| Samapex Tech Ltd | Information & communication | 2025 |
| Samara Exports Limited | Wholesale & retail | 2025 |
| Sambridhi Private Limited | Real estate | 2025 |
| Samdaniels Associates Limited | Professional & scientific | 2011 |
| Sameday Express Couriersuk Ltd | Transport & logistics | 2024 |
| Samfin Properties Ltd | Real estate | 2023 |
| Samick Consult Ltd | Health & social care | 2018 |
| Samjoy Ltd | Health & social care | 2020 |
| Sampran Global Resources Limited | Construction | 2012 |
| Sampson Group Limited | Financial services | 2025 |
| Sampuk Ltd | Wholesale & retail | 2024 |
| SAN & PR Ltd | Hospitality | 2024 |
| SAN LIN Homes Ltd | Construction | 2023 |
| Sanarc Assets Ltd | Real estate | 2023 |
| Sandhu Brothers Transport Ltd | Transport & logistics | 2021 |
| Sandhurst Plant Limited | Wholesale & retail | 1972 |
| Sandriner Ltd | Administrative & support | 2024 |
| Sandringham Property Solutions Ltd | Real estate | 2024 |
| Sane F&B Ltd | Hospitality | 2023 |
| Sangha Renovations Ltd | Construction | 2025 |
| Sanjack Building Co Ltd | Water & waste | 2020 |
| Sanrup Holdings Limited | Financial services | 2023 |
| Sanrup Ventures Limited | Real estate | 2024 |
| Sans Bean Limited | Wholesale & retail | 2014 |
| Sansee Medical Ltd | Health & social care | 2011 |
| Sansee Properties Ltd | Real estate | 2023 |
| Santerik Healthcare Limited | Health & social care | 2014 |
| Santos Construction Limited | Construction | 2017 |
| Santos Services Limited | Construction | 2016 |
| Sanvicentej Ltd | Health & social care | 2023 |
| Sanzea Trendz Limited | Wholesale & retail | 2025 |
| Sapientia Management Ltd | Real estate | 2022 |
| Sapior Ltd. | Information & communication | 2000 |
| Sapphire Horizon Limited | Real estate | 2025 |
| Sapphire Tuesday Ltd | Real estate | 2024 |
| Saqab Raza Traders Ltd | Wholesale & retail | 2022 |
| Sarah Chambers Consulting Ltd | Arts & recreation | 2017 |
| Sarahjanecreations Ltd | Wholesale & retail | 2025 |
| Sargent Brothers (Thames) Limited | Transport & logistics | 1951 |
| Saro DW Ltd | Wholesale & retail | 2018 |
| Sarthak Limited | Real estate | 2020 |
| Sarup Ltd | Real estate | 2024 |
| Sarvesh Properties and Investments Limited | Real estate | 2022 |
| Saryn Capital Ltd | Professional & scientific | 2025 |
| SAS Roofing Specialists Ltd | Construction | 2013 |
| Sash Window Doctor Limited | Construction | 2016 |
| Sashee International Ltd | Wholesale & retail | 2025 |
| Saslyitics Limited | Professional & scientific | 2013 |
| Sassyy Ltd | Construction | 2025 |