| Decorating by George Limited | Construction | 2024 |
| Decorative & Ornamental Plastering Limited | Construction | 2010 |
| Decs Kent Limited | Construction | 2014 |
| Decsmn Ltd | Wholesale & retail | 2025 |
| DEE 3 Limited | Information & communication | 2020 |
| Dee's Cakes & Pastries Limited | Manufacturing | 2013 |
| Deecon Property Asset Management Ltd | Real estate | 2025 |
| Deepgenai Solutions Limited | Information & communication | 2025 |
| Deeproot IT Consulting Ltd | Information & communication | 2015 |
| Deeproot Nutrition & Wellness Ltd | Health & social care | 2021 |
| Deerkat Limited | Professional & scientific | 2020 |
| Deerleap Developments Limited | Construction | 2025 |
| Deerleap Properties Limited | Construction | 2010 |
| Deesbeautyybar Ltd | Other services | 2023 |
| Define Academy Ltd | Other services | 2019 |
| Define Original Ltd | Information & communication | 2021 |
| Definite Immigration Solutions Limited | Professional & scientific | 2016 |
| DEG Recruitment Ltd | Construction | 2019 |
| Deji Jones Associates Limited | Professional & scientific | 2016 |
| Dekel Consulting Ltd | Other services | 2015 |
| Dekojo Ltd | Other services | 2014 |
| Delawga DEI Chamber Limited | Professional & scientific | 2025 |
| Delawi Ltd | Real estate | 2021 |
| Dele Autos Garage Limited | Wholesale & retail | 2009 |
| Deli Counters Limited | Wholesale & retail | 2003 |
| Dellerose Ltd | Real estate | 2023 |
| Delmark Lifting Equipment Limited | Manufacturing | 1986 |
| Delovelo Ltd | Manufacturing | 2026 |
| Delphine Philip Law Limited | Professional & scientific | 2017 |
| Delred Construction Solutions Ltd | Construction | 2017 |
| Delred Developments Ltd | Real estate | 2020 |
| Delta Delight Ltd | Hospitality | 2026 |
| Delta Lease Limited | Extraterritorial | 2021 |
| Delta Security Services Limited | Administrative & support | 2023 |
| Delta Spa Limited | Professional & scientific | 1986 |
| Delux Ltd | Extraterritorial | 2006 |
| Deluxxe Company Ltd | Real estate | 2023 |
| Demeks Group UK Ltd | Health & social care | 2025 |
| Deminek Patego (UK) Company Ltd. | Administrative & support | 2016 |
| Demis Trans Ltd | Other services | 2018 |
| Denby Contractors Limited | Professional & scientific | 2019 |
| Dene Properties Limited | Construction | 2014 |
| Denga Systems Ltd. | Professional & scientific | 2015 |
| Denis Crowley Limited | Professional & scientific | 2014 |
| Denman Chain Management Ltd | Professional & scientific | 2025 |
| Denmmac UK Ltd | Administrative & support | 2010 |
| Denzel & Ryan Ltd | Professional & scientific | 2025 |
| Denzel Zenith Ltd | Professional & scientific | 2024 |
| DEO Makro UK Limited | Professional & scientific | 2011 |
| Deo-Leo Global Limited | Wholesale & retail | 2026 |
| Deon Properties Ltd | Real estate | 2022 |
| Deotech Limited | Construction | 2009 |
| Deptford Bar & Restaurant Ltd | Hospitality | 2024 |
| Depth Holdings Ltd | Manufacturing | 2025 |
| Derek LEE Limited | Construction | 2017 |
| Derna Ltd | Health & social care | 2018 |
| Deron Hires Ltd | Hospitality | 2017 |
| Derosa Music Canterbury Ltd | Education | 2026 |
| Derric Limited | Professional & scientific | 2010 |
| DES Walsh Research Limited | Administrative & support | 2023 |
| Design & Dwell Limited | Professional & scientific | 2024 |
| Design Direct 2024 Ltd | Wholesale & retail | 2024 |
| Designartech IT Services Ltd | Information & communication | 2010 |
| Designed by Josh Ltd | Extraterritorial | 2019 |
| Designed Plastercraft Associates Ltd | Construction | 2020 |
| Designer Shepherd Limited | Wholesale & retail | 2024 |
| Designs Cafe Ltd | Hospitality | 2025 |
| Desirable Living Limited | Real estate | 2017 |
| Desire Estate Limited | Extraterritorial | 2013 |
| Desmond Imaging Consultancy Ltd | Health & social care | 2021 |
| Desnica Mortgage Services Ltd | Financial services | 2025 |
| Dessert Haven Crayford Limited | Hospitality | 2024 |
| Dessertz Bar Ltd | Hospitality | 2022 |
| Desskie Ltd | Health & social care | 2021 |
| Destiny Experiences Limited | Administrative & support | 2021 |
| Destiny Real Estate Ltd | Real estate | 2025 |
| Detail Services Ltd | Professional & scientific | 2018 |
| Detail Spec Limited | Construction | 2014 |
| Detailed Waterproofing Services Ltd | Construction | 2017 |
| Determined to Thrive Ltd | Extraterritorial | 2025 |
| Detin Limited | Real estate | 2024 |
| Deus Invictus Ltd | Wholesale & retail | 2025 |
| DEUT1012 Ltd | Information & communication | 2025 |
| DEV LPT Limited | Professional & scientific | 2024 |
| Developed Controls Ltd. | Construction | 2013 |
| Development Results International Ltd | Professional & scientific | 2024 |
| Deville Studios Ltd | Information & communication | 2026 |
| Devils Palette Ltd | Manufacturing | 2021 |
| Devo Investment Limited | Real estate | 2019 |
| Devotion Properties Ltd | Real estate | 2018 |
| Devstar Property Holdings Limited | Real estate | 2025 |
| Dewlands Properties Limited | Real estate | 2017 |
| Dezine Consultancy Ltd | Professional & scientific | 2024 |
| Dfcs London Ltd | Other services | 2026 |
| DFE Contractors Ltd | Construction | 2015 |
| Dfos Properties Ltd | Real estate | 2023 |
| Dfsa Repairs Ltd | Wholesale & retail | 2020 |
| DG Ductwork Ltd | Construction | 2018 |
| Dgfix Ltd | Construction | 2017 |
| DGK Investment Holdings Ltd | Real estate | 2020 |