| RUT Trans Ltd | Transport & logistics | 2024 |
| Ruth Roddam Limited | Real estate | 2011 |
| Ruth Waterfall-Brown Limited | Wholesale & retail | 2004 |
| Rutherford Projects Limited | Professional & scientific | 2013 |
| RW Access Limited | Construction | 2022 |
| RW GAS & Heating Services Ltd | Construction | 2023 |
| RW Safety Consulting Ltd | Professional & scientific | 2022 |
| Ryan B Sales Ltd | Professional & scientific | 2025 |
| Ryan Beal Logistics Ltd | Transport & logistics | 2025 |
| Ryan Edward Donaldson Private Wealth Ltd | Administrative & support | 2022 |
| Rylstone Holdings Ltd | Extraterritorial | 2018 |
| S & K 3D Printing Ltd | Manufacturing | 2026 |
| S & M Commercials Limited | Real estate | 2023 |
| S & R Cars Limited | Transport & logistics | 2004 |
| S & S Rope Access Systems Ltd | Construction | 2024 |
| S & Z Consultants Ltd | Professional & scientific | 2011 |
| S and L Motor Vehicle Services Limited | Wholesale & retail | 2013 |
| S and R Trading Ltd | Wholesale & retail | 2018 |
| S Bennett Properties Ltd | Real estate | 2022 |
| S D Surveying Ltd | Agriculture & fishing | 2019 |
| S Darrell Maintenance Limited | Construction | 2017 |
| S Devlin Properties Ltd | Households | 2022 |
| S G Petch (Roadways) Ltd | Real estate | 2026 |
| S Islam Optical Ltd | Health & social care | 2024 |
| S J Hawksworth Ltd | Financial services | 2022 |
| S K B (NE) Ltd | Other services | 2024 |
| S K Pharmacare Newcastle Ltd | Wholesale & retail | 2025 |
| S K Pharmacare North East Limited | Wholesale & retail | 2025 |
| S K Ventura Ltd | Health & social care | 2020 |
| S Oliver Holdings Limited | Construction | 2024 |
| S Taylor Painting & Property Services Ltd | Construction | 2022 |
| S W Improvements Ltd | Construction | 2023 |
| S&B PR Ltd | Professional & scientific | 2025 |
| S&J Hair 2 Limited | Other services | 2024 |
| S&K Properties Yorkshire Ltd | Hospitality | 2019 |
| S&P Exteriors Ltd | Administrative & support | 2026 |
| S.A.Wrightson Forestry Contractors Ltd | Wholesale & retail | 2009 |
| S.C Waste Removal Limited | Transport & logistics | 2025 |
| S.E.M. Electrical Limited | Construction | 2004 |
| S.Hartley and SON Ltd | Manufacturing | 2018 |
| S.J.I. Limited | Wholesale & retail | 2002 |
| S.M.B. 4X4 Limited | Wholesale & retail | 2005 |
| S.P.H Engineering Ltd | Professional & scientific | 2024 |
| S.R Foods Limited | Hospitality | 2019 |
| S.V.Kelly Ltd | Transport & logistics | 2014 |
| S.Wright Logistics Limited | Transport & logistics | 2026 |
| S25D Limited | Information & communication | 2000 |
| Sabhan Limited | Wholesale & retail | 2023 |
| Sabharwal & Sons Ltd | Wholesale & retail | 2023 |
| Sadberge Beers Ltd | Hospitality | 2019 |
| Sadberge Pre-School Group Limited | Education | 2026 |
| Sadberge Renewable Energy Limited | Energy | 2011 |
| Saddington Taylor Limited | Professional & scientific | 2016 |
| Sade Business Solutions Limited | Professional & scientific | 2025 |
| Saet Holdings Ltd | Financial services | 2026 |
| Safe Access and Inspection Limited | Professional & scientific | 2017 |
| Safe Arms Safety Ltd | Mining & quarrying | 2014 |
| Safe AS Huysers Lettings Limited | Real estate | 2018 |
| Safeguard Contracts Ltd | Construction | 2016 |
| Safer School Streets Limited | Transport & logistics | 2024 |
| Saffiyah Property Ltd | Construction | 2019 |
| Saffronbites Ltd | Wholesale & retail | 2024 |
| Sagm Associates Limited | Professional & scientific | 2022 |
| Sail Investments Ltd | Real estate | 2023 |
| Saint & Forster Funeral Directors Ltd | Other services | 2011 |
| Saint Andrews Park Property Management Group Limited | Households | 2025 |
| Saint John of GOD Hospitaller Services | Health & social care | 2005 |
| Saints ROW Brewing Co. Ltd. | Manufacturing | 2016 |
| Saks Academies Limited | Education | 2012 |
| Saks Accounting Services Limited | Professional & scientific | 2021 |
| Saks Hair (Holdings) Limited | Other services | 1988 |
| Saks Hair International Limited | Other services | 2011 |
| Saks HB Limited | Other services | 2012 |
| Saks Limited | Extraterritorial | 2002 |
| Salon Serendipity Ltd | Other services | 2023 |
| Salt Rentals Ltd | Real estate | 2025 |
| Salt Steel Brewing Co Ltd | Manufacturing | 2019 |
| Saltburn & Brotton Seafoods Limited | Wholesale & retail | 2017 |
| Saltire Roofcare UK Ltd | Construction | 2025 |
| Salus Therapies Ltd | Health & social care | 2018 |
| Salvaje Skincare Ltd | Manufacturing | 2024 |
| SAM Clennell Motorsport Ltd | Wholesale & retail | 2022 |
| SAM Nattress Gardens Ltd | Administrative & support | 2020 |
| Same Day Salvage Ltd | Wholesale & retail | 2025 |
| Samira 24 Ltd | Hospitality | 2024 |
| Samira Online Ltd | Wholesale & retail | 2025 |
| Samson Forth Associates Limited | Professional & scientific | 2021 |
| Samsung C&T Ecuk Limited | Professional & scientific | 2012 |
| Samuel Barber Limited | Other services | 2017 |
| Sand & Deliver Ltd | Construction | 2025 |
| Sandancer Leisure Ltd | Arts & recreation | 2007 |
| Sandbach Party Supplies Ltd | Wholesale & retail | 2020 |
| Sanders Swinbank Limited | Professional & scientific | 2000 |
| Sandhu's Chippy Ltd | Hospitality | 2026 |
| Sandringham Court (L'Pool) RTM Company Limited | Households | 2014 |
| Sandringham Court Management (Picktree) Limited | Households | 2004 |
| Sangha Stores (NE) Limited | Wholesale & retail | 2016 |
| Sanghu Property Investments Ltd | Real estate | 2025 |
| Sans Enterprise Ltd | Transport & logistics | 2025 |
| Sansom Joinery Ltd | Manufacturing | 2015 |