| Serghei C Carpentry Ltd | Construction | 2023 |
| Sergiu Bujdei Ltd | Construction | 2026 |
| Servicetech Solutions Ltd | Information & communication | 2026 |
| Servix FM Ltd | Administrative & support | 2026 |
| Serwaa’S Home Ltd Ltd | Wholesale & retail | 2026 |
| SES (Security Employment Solutions) Ltd | Administrative & support | 2025 |
| Seshat Advertising Ltd | Professional & scientific | 2023 |
| Seth Guild Ltd | Hospitality | 2025 |
| Sets Holdings Limited | Financial services | 2015 |
| Seven Seas Travel Ltd | Administrative & support | 2024 |
| Sevenkimgs Property Services Ltd | Real estate | 2024 |
| Seventh Circle Artworks Limited | Manufacturing | 2013 |
| SEW IT in London UK Limited | Manufacturing | 2018 |
| Seyishow International Ltd | Administrative & support | 2020 |
| SF Pizza & Grill Ltd | Hospitality | 2026 |
| SF Properties MCR Limited | Real estate | 2025 |
| SF Property Ventures Ltd | Real estate | 2025 |
| SFS Marketing Ltd | Administrative & support | 2025 |
| SG Allien Limited | Construction | 2024 |
| SG Plumbing Supplies Ltd | Wholesale & retail | 2015 |
| SGL Transport Ltd | Transport & logistics | 2025 |
| SGM Builders Limited | Construction | 2024 |
| SGM Perfect Ltd | Construction | 2026 |
| SH Optiics Limited | Professional & scientific | 2019 |
| SH Transport London Ltd | Transport & logistics | 2024 |
| Shaad Sweets & Bakery Ltd | Manufacturing | 2025 |
| Shabbychildcare Limited | Education | 2024 |
| Shadowcat Consulting Limited | Professional & scientific | 2019 |
| Shafnafaz Limited | Health & social care | 2020 |
| Shafton Ltd | Professional & scientific | 2019 |
| Shaggy.Beauty Limited | Other services | 2023 |
| Shah Builders & Decorators Ltd | Construction | 2012 |
| Shah G Autos Limited | Wholesale & retail | 2026 |
| Shah Serenity Ltd | Wholesale & retail | 2024 |
| SHAKA1977 Exports & Imports Ltd | Wholesale & retail | 2018 |
| Shakti Hardware and Houseware Limited | Wholesale & retail | 2021 |
| Shala Services Ltd | Construction | 2015 |
| Shalom Health Recruitment Ltd | Administrative & support | 2013 |
| Shalom Ltd | Health & social care | 2012 |
| Shamaila's Boutique (UK) Ltd | Wholesale & retail | 2013 |
| Shamji Properties Limited | Real estate | 2024 |
| Shamronette Limited | Health & social care | 2014 |
| Shamverse Ltd | Wholesale & retail | 2025 |
| Shan - Bright Hope Ltd | Education | 2025 |
| Shan Zahra Aleem Ltd | Wholesale & retail | 2025 |
| Shan-Charitable Trust | Health & social care | 2012 |
| Shantys Limited | Wholesale & retail | 1979 |
| Shaormeria Bucuresti Ltd | Hospitality | 2025 |
| Shaoxing Lemu Textile Co Ltd | Manufacturing | 2026 |
| Shapeup FC Ltd | Education | 2026 |
| Shapla Estate Management Ltd | Real estate | 2020 |
| Shapo Technologies Limited | Information & communication | 2023 |
| Sharaar Limited | Wholesale & retail | 2025 |
| Sharada Technologies Ltd | Information & communication | 2014 |
| Share the Link Ltd | Information & communication | 2026 |
| Sharewood Homes U.K Limited | Real estate | 2024 |
| Sharma London Construction Ltd | Construction | 2026 |
| Sharptech Limited | Administrative & support | 2025 |
| Shaudrey Limited | Health & social care | 2014 |
| Shayaan Travels Ltd | Administrative & support | 2023 |
| Shayan & Hoorain Limited | Transport & logistics | 2024 |
| Shaydee Evolve Limited | Public administration | 2025 |
| Shbgcleaning Limited | Administrative & support | 2021 |
| Sheen's Estates Ltd | Real estate | 2023 |
| Sheenz Hair and Beauty Limited | Other services | 2025 |
| Sheerness Food Investments Limited | Hospitality | 2026 |
| Sheesham Interiors Ltd | Wholesale & retail | 2018 |
| Sheesham Ltd | Wholesale & retail | 2019 |
| Shefunmex Services Limited | Real estate | 2026 |
| Sheik Services Ltd | Professional & scientific | 2025 |
| Shekhinah Rainbow Homes Ltd | Real estate | 2026 |
| Shelf Spring Ltd | Wholesale & retail | 2026 |
| Shelly Sports Ltd | Wholesale & retail | 2020 |
| Sheltech Support Ltd | Health & social care | 2026 |
| Shelter Homes Limited | Hospitality | 2019 |
| Shelter Life CIC | Health & social care | 2024 |
| Sherrymaken Ltd | Wholesale & retail | 2025 |
| Sherylmadeit Ltd | Hospitality | 2025 |
| Sheta Ltd | Water & waste | 2025 |
| SHG Pest Control Ltd | Other services | 2017 |
| Shiddat Holding Ltd | Construction | 2025 |
| Shield Guard Security Limited | Administrative & support | 2019 |
| Shield Property Investments Limited | Real estate | 2022 |
| Shifat Domestic Cleaning Ltd | Education | 2026 |
| Shiforia Ltd | Information & communication | 2025 |
| Shifting Purpose CIC | Education | 2026 |
| Shikem Global Limited | Hospitality | 2022 |
| Shining Star Double Glazing Ltd | Construction | 2024 |
| Shinyncutie Limited | Manufacturing | 2019 |
| Ship N Global Ltd | Real estate | 2017 |
| Shiv SAI Builder Ltd | Construction | 2019 |
| Shiva Food and Vegetable Limited | Wholesale & retail | 2023 |
| Shivtaj Consultancy Ltd | Professional & scientific | 2020 |
| SHJ London Ltd | Administrative & support | 2023 |
| Shlok & Swaha Ltd | Information & communication | 2023 |
| SHM Property Services Ltd | Real estate | 2026 |
| Sho-F Drive Ltd | Transport & logistics | 2022 |
| Shodesh Indian Ltd | Hospitality | 2025 |
| Shokey Properties London Ltd | Real estate | 2024 |
| Shokolarova Limited | Administrative & support | 2019 |