| Red Monkey Software Limited | Information & communication | 2006 |
| Red Square Networks Ltd | Wholesale & retail | 2024 |
| Reflect & Refocus Positive Change Coaching CIC | Health & social care | 2024 |
| Reflectalux Mirror Wardrobes Limited | Extraterritorial | 1984 |
| Regenerative Revolution Limited | Wholesale & retail | 2023 |
| Rehman Choice Ltd | Wholesale & retail | 2025 |
| Remnant Developments Ltd | Construction | 2023 |
| Remy’S Autos Ltd | Wholesale & retail | 2026 |
| Renegade Motorcycle Tyres Limited | Wholesale & retail | 2025 |
| RESTORE44 Ltd | Wholesale & retail | 2018 |
| Retro Records Ltd | Wholesale & retail | 2024 |
| RH Cole Consultancy Ltd | Other services | 2016 |
| RH Cole Properties Ltd | Real estate | 2025 |
| RHB Tooling Services Limited | Manufacturing | 2012 |
| Rhino Management Ltd | Professional & scientific | 2023 |
| Rhodes Property Services Ltd | Administrative & support | 2002 |
| Rhydimoor Farms Limited | Manufacturing | 2012 |
| Rhydwen Farms Limited | Agriculture & fishing | 2023 |
| Richard Griffiths Ltd | Manufacturing | 2008 |
| Richardson Realty Limited | Real estate | 2014 |
| Richardson Roofing Solutions Limited | Construction | 2023 |
| Ridgeway House (Bristol) Limited | Health & social care | 2010 |
| RIO Property Investment Ltd | Real estate | 2020 |
| Riseanna Ltd | Hospitality | 2025 |
| Rival Scaffolding Ltd | Construction | 2020 |
| RJD Jenkins Limited | Health & social care | 2006 |
| RJM Consultancy Ltd | Information & communication | 2015 |
| RJP Mobile Service Ltd | Wholesale & retail | 2025 |
| RME Property Investments Ltd | Construction | 2024 |
| ROB Williams Landscaping Limited | Professional & scientific | 2016 |
| Robert C Green Shopfitters Ltd | Construction | 2026 |
| Robert Russell Property Services Limited | Construction | 2019 |
| Roberts WAX Melts CYF | Other services | 2025 |
| Robin Willis Motor Company Limited | Wholesale & retail | 2022 |
| Robyn Aubrey Wealth Management Ltd | Financial services | 2018 |
| Roche Commercial Ltd | Real estate | 2024 |
| Rockfield Fabrications Ltd | Manufacturing | 2021 |
| Roelands Motorsport (UK) Limited | Manufacturing | 2014 |
| Rogerstone Landscaping & Driveways Limited | Construction | 2017 |
| Rolyat Chepstow Limited | Real estate | 2018 |
| Rolyat Sisteam Limited | Real estate | 2022 |
| Rolyat Speke Limited | Real estate | 2019 |
| Rolyat Training Limited | Education | 2019 |
| Roman Fortis Ltd | Manufacturing | 2025 |
| Ronan's Boys Ltd. | Wholesale & retail | 2016 |
| Rongrove Industries Ltd | Manufacturing | 2024 |
| Rose Gardens Management Company Limited | Hospitality | 1989 |
| Rostr Limited | Information & communication | 2026 |
| Rozino CWM Ltd | Hospitality | 2025 |
| RPS Telecom Ltd | Information & communication | 2005 |
| RRM Housing Ltd | Real estate | 2020 |
| RT Business System Solutions Ltd | Information & communication | 2021 |
| RTB Electrical Limited | Construction | 2014 |
| Rubin Lewis O'Brien LLP | | 2008 |
| Rugby Heaven Ltd | Wholesale & retail | 2009 |
| Rural Homes (Cwmbran) Limited | Wholesale & retail | 1966 |
| Rural Property Professionals Limited | Administrative & support | 2008 |
| Rus-Haulage Ltd | Transport & logistics | 2024 |
| Ruttley Property Investment Ltd | Real estate | 2025 |
| S & B Developments Limited | Real estate | 1997 |
| S & C Property Developments Ltd | Real estate | 2019 |
| S & D R | Real estate | 2021 |
| S & E Shine Ltd | Other services | 2025 |
| S & L ALM Carpentry and Building Contractors Ltd | Manufacturing | 2023 |
| S a W & Sons Ltd | Transport & logistics | 2016 |
| S Hiscox Associates Ltd | Financial services | 2021 |
| S J R Fleet Assist Ltd | Manufacturing | 2016 |
| S. Riddoch Limited | Professional & scientific | 2018 |
| S2 Construction Services Ltd | Construction | 2017 |
| Sabre Supplies Ltd | Wholesale & retail | 2026 |
| Safe Haven Surveyors Ltd | Professional & scientific | 2025 |
| Safehouse Technology Ltd | Manufacturing | 2018 |
| Safran Seats GB Investment Limited | Financial services | 2012 |
| Safran Seats GB Limited | Manufacturing | 1933 |
| Safz Estates Newport Ltd | Real estate | 2024 |
| Sahana & Archana Properties Ltd | Real estate | 2025 |
| Salon Michael & Alexander Ltd | Other services | 2017 |
| Salon Rene Limited | Other services | 2011 |
| Sammos Limited | Transport & logistics | 2020 |
| Santa Health Care Limited | Health & social care | 2022 |
| Sara Butler Ltd | Education | 2023 |
| Sara Retail Ltd | Wholesale & retail | 2025 |
| SB Farms Ltd | Agriculture & fishing | 2021 |
| SC & Sons Property Management Ltd | Real estate | 2023 |
| Scalable Information Systems Limited | Information & communication | 2005 |
| Scarfi Media Ltd | Information & communication | 2026 |
| Schaltbau Machine Electrics Limited | Manufacturing | 2008 |
| SCJ Facilities Limited | Construction | 2018 |
| Scott Roberts Holdings Limited | Financial services | 2025 |
| Scruffy K9S Ltd | Other services | 2025 |
| SDR Rehabilitation UK Ltd | Arts & recreation | 2015 |
| Sea Salt Property Ltd | Households | 2022 |
| Sealant Applications (Cymru) Limited | Construction | 2010 |
| Sear Digital Ltd | Wholesale & retail | 2019 |
| Secure One Solutions Ltd | Administrative & support | 2019 |
| Secure Sensor Innovative Design Ltd | Information & communication | 2013 |
| Seek Property Management Services Ltd | Real estate | 2022 |
| Seine and Loire Ltd | Manufacturing | 2026 |
| Senior Property Management Limited | Real estate | 2017 |
| Sensible Branding Limited | Professional & scientific | 2015 |