| D. Stoker Group Limited | Wholesale & retail | 1961 |
| D.K. Atkinson Electrical Contractors Ltd | Construction | 2003 |
| DAC Professional Services Limited | Administrative & support | 2026 |
| DAISY5 Ltd | Other services | 2020 |
| Dalton in Furness PO Limited | Administrative & support | 2007 |
| Dandy's Limited | Wholesale & retail | 2002 |
| Daniel Spedding Deliveries Ltd | Transport & logistics | 2022 |
| Dark Horse Racing Limited | Arts & recreation | 2003 |
| David Balmer Carpets Limited | Construction | 2002 |
| David Capstick Limited | Financial services | 2019 |
| David Greenbank Tyres & Towing Ltd | Wholesale & retail | 2003 |
| David Lowther Limited | Other services | 2006 |
| Dean Moor Off-Road Park Limited | Arts & recreation | 2004 |
| Debonair Ltd | Other services | 2003 |
| Decommissioning Management Consultancy DMC Limited | Professional & scientific | 2003 |
| Deltawaite (NBE) Limited | Extraterritorial | 1965 |
| Denby & Co Solicitors Limited | Professional & scientific | 2007 |
| Denmire Farms Limited | Administrative & support | 2007 |
| Derek Wilson Limited | Construction | 2005 |
| Derwent Fluid Properties Limited | Real estate | 2007 |
| Dirt & Damp Limited | Health & social care | 2002 |
| DNB Electrical and Heating Solutions Ltd | Construction | 2016 |
| Dobcross Hall Limited | Agriculture & fishing | 2007 |
| Docker Joinery Limited | Construction | 2002 |
| Dodd & Co Services Limited | Administrative & support | 2007 |
| Double TEE Tools Ltd | Wholesale & retail | 2003 |
| Douglas Cowley Limited | Construction | 2003 |
| Downton Travel Limited | Transport & logistics | 2005 |
| Droxie Ltd | Information & communication | 2020 |
| Drumburgh Castle Farming Co | Agriculture & fishing | 2007 |
| Duffy Enterprises Limited | Hospitality | 2002 |
| Dundraw Farm | Agriculture & fishing | 2007 |
| E & M Jackson Limited | Construction | 2002 |
| E & S Scaffolding Limited | Construction | 2006 |
| E Moorhouse & Sons Limited | Construction | 2005 |
| E.S. Gainford & SON Ltd. | Wholesale & retail | 2003 |
| Eason Podiatry Ltd | Health & social care | 2003 |
| East Woodside Farming | Agriculture & fishing | 2007 |
| Eclectic Creative Limited | Professional & scientific | 2012 |
| Ecological Building Systems U.K. Limited | Construction | 2006 |
| Eden Mortgages Limited | Financial services | 2002 |
| Eden Property Investment Portfolio Number 2 LLP | | 2026 |
| Eden Recycling Cumbria Ltd | Water & waste | 2008 |
| Eden Valley Fish Restaurant Limited | Hospitality | 2003 |
| Eden Valley Hospice, Carlisle | Health & social care | 1992 |
| Edenhall Autosalvage + Metals Limited | Wholesale & retail | 2007 |
| Edward Waddington Limited | Administrative & support | 2003 |
| Edwin Thompson Limited Liability Partnership | | 2003 |
| Egremont Mining Company Limited(The) | Mining & quarrying | 1981 |
| Elliott & Edwards Limited | Professional & scientific | 2002 |
| Elliott Engineering (Carlisle) Limited | Manufacturing | 2006 |
| Engad Limited | Professional & scientific | 2007 |
| Engineering Solutions Limited | Professional & scientific | 2005 |
| Eric Hagan Opticians Limited | Health & social care | 2006 |
| Eric Ward Hair Limited | Other services | 2003 |
| Eurotech Combustions Limited | Extraterritorial | 1988 |
| Evening Hill Farm Limited | Agriculture & fishing | 2007 |
| EWB Cotton Limited | Manufacturing | 2002 |
| F J Lister & SON Limited | Agriculture & fishing | 2007 |
| Face to Face Financial Services Ltd | Financial services | 2003 |
| Fairladies Barn Limited | Hospitality | 2007 |
| Farm & Industrial Structures Limited | Construction | 2002 |
| Favourstate Limited | Construction | 1983 |
| FCW Properties Limited | Real estate | 2007 |
| Fearon Flowers (06) Limited | Wholesale & retail | 2006 |
| Fellview Joinery Ltd | Manufacturing | 2009 |
| FIG Tree (Barrow) Ltd | Hospitality | 2002 |
| Finishing Touch (Kendal) Ltd | Construction | 2002 |
| Fiona Reed Associates Limited | Professional & scientific | 2005 |
| Fire Risk Engineers Ltd | Construction | 2005 |
| Fisher Farming Limited | Agriculture & fishing | 2006 |
| Fiza Spice Ltd | Hospitality | 2017 |
| Fletcher Contract Cleaning Limited | Wholesale & retail | 1991 |
| Flexmr Limited | Information & communication | 2006 |
| Floral Design (Cumbria) Limited | Wholesale & retail | 2003 |
| Floshes Farm Limited | Agriculture & fishing | 2006 |
| Flowers by Arrangement Limited | Wholesale & retail | 2004 |
| FMB (Holdings) Limited | Professional & scientific | 2004 |
| Fowrass | Agriculture & fishing | 2006 |
| FOX Fencing Ltd | Administrative & support | 2005 |
| Fraser Fries Limited | Wholesale & retail | 2002 |
| Free for ALL Community Recycling Ltd | Water & waste | 2003 |
| Frizington White Star Football Club | Hospitality | 2005 |
| FSA (Barrow) Limited | Arts & recreation | 2017 |
| Fueltronics Ltd | Manufacturing | 2003 |
| Full Circle Education Limited | Education | 2018 |
| Funschool Limited | Professional & scientific | 1994 |
| Furmanite International Finance Limited | Financial services | 2006 |
| Furness Audit Limited | Professional & scientific | 2007 |
| Furness Brick & Tile Company Limited(The) | Manufacturing | 1898 |
| Furness Dental Laboratory Limited | Health & social care | 2003 |
| Furness Heating Components Limited | Wholesale & retail | 1999 |
| Furness of Keswick Limited | Administrative & support | 2002 |
| Furness Watch & Jewellery Limited | Other services | 2003 |
| Futamura British Pension Trustee Limited | Administrative & support | 2016 |
| Fylde Guitars Limited | Manufacturing | 2003 |
| G & D J Baird Limited | Agriculture & fishing | 2006 |
| G C Croasdale Limited | Extraterritorial | 2000 |
| G H Interiors Limited | Construction | 2003 |
| G M Porter Limited | Wholesale & retail | 2005 |