| Shop Aesthetics Ltd | Wholesale & retail | 2025 |
| Shop Deals Ltd | Wholesale & retail | 2025 |
| Shop on the Green Chartham Limited | Wholesale & retail | 2017 |
| Shop Shire Ltd | Wholesale & retail | 2024 |
| Shop Wise Trade Ltd | Wholesale & retail | 2023 |
| Shopfront Shutters Limited | Manufacturing | 2014 |
| Shopimo Ltd | Wholesale & retail | 2017 |
| Shopique Limited | Wholesale & retail | 2025 |
| Shopnbits Ltd | Wholesale & retail | 2022 |
| Shopnfly Freight Service Ltd | Transport & logistics | 2025 |
| Shopper's Paradise Ltd | Wholesale & retail | 2015 |
| Shore Plumbing & Heating Ltd | Construction | 2022 |
| Shorefx Limited | Transport & logistics | 2009 |
| Shortcut Films Ltd | Professional & scientific | 2023 |
| Shorty Productions Limited | Information & communication | 2015 |
| Show ME WOT YOU GOT | Education | 2018 |
| Show Media International Ltd | Information & communication | 2017 |
| Showells Norbury Ltd | Wholesale & retail | 2023 |
| Showffuer Ltd | Transport & logistics | 2025 |
| Shree Dambab Super Store Ltd | Wholesale & retail | 2026 |
| Shree Datta Ltd | Wholesale & retail | 2019 |
| Shree Entertainment Ltd | Professional & scientific | 2023 |
| Shree Krishna Convenience Limited | Wholesale & retail | 2026 |
| Shree Krishna Properties Limited | Real estate | 2022 |
| Shree Nagapoosani Amman Temple Ltd | Other services | 2022 |
| Shree Santram Ltd | Health & social care | 2024 |
| Shree Shiv Limited | Real estate | 2026 |
| Shree Vishwa Sanaatan Dharma Mandir Ltd | Other services | 2023 |
| Shree Vsdm Limited | Other services | 2025 |
| Shresth Foods UK Ltd | Hospitality | 2025 |
| Shri Annamaar Ltd | Wholesale & retail | 2025 |
| Shri Krishna Scooperb Limited | Hospitality | 2023 |
| Shri Vimalnath Limited | Wholesale & retail | 2024 |
| Shriji News Limited | Wholesale & retail | 2021 |
| Shrinathji Holdings Limited | Financial services | 2026 |
| Shrinathji Properties Limited | Real estate | 2025 |
| Shrisaya Limited | Wholesale & retail | 2018 |
| Shukla Holdings Limited | Wholesale & retail | 2002 |
| Shukla Quality Retail Limited | Wholesale & retail | 2026 |
| Shukla's Londis Limited | Wholesale & retail | 2002 |
| Shuklas of Penge Ltd | Wholesale & retail | 2002 |
| Shun LEE Kitchen Limited | Hospitality | 2020 |
| Shutter Studio Franchise Limited | Professional & scientific | 2025 |
| Shutters for Less Limited | Construction | 2024 |
| Shyam Music Limited | Arts & recreation | 2025 |
| Shyne Ltd | Information & communication | 2015 |
| Shyro Tattoo Studio Ltd | Water & waste | 2020 |
| Siaii Ltd | Information & communication | 2025 |
| Siam Wellness Ltd | Other services | 2023 |
| SIAM2GETHER Ltd | Hospitality | 2023 |
| Siba Productions Ltd | Information & communication | 2019 |
| Sibirka Ltd | Wholesale & retail | 2025 |
| Sica Removals Ltd | Transport & logistics | 2019 |
| Sicg Ltd | Other services | 2025 |
| Sicily Catering Ltd | Hospitality | 2020 |
| Sickle Synced CIC | Education | 2026 |
| Siddhu & Thanu Limited | Real estate | 2025 |
| Sidelight Productions Limited | Arts & recreation | 2024 |
| Sidhu Retail Limited | Wholesale & retail | 2022 |
| Sidiqi Construction Works Limited | Construction | 2018 |
| Sierra Atlantic Care Ltd | Health & social care | 2023 |
| Sierra Atlantic Ltd | Wholesale & retail | 2022 |
| Sifi Solutions Limited | Professional & scientific | 2024 |
| Sigma Sonics Ltd | Manufacturing | 2021 |
| Sigma Synergy Group Limited | Other services | 2009 |
| Sigmaa Heating and Boiler Installation Ltd | Manufacturing | 2023 |
| Signal Coalition Brewing Limited | Manufacturing | 2014 |
| Signal Digital Ltd | Professional & scientific | 2026 |
| Signature Brands UK Ltd | Wholesale & retail | 2017 |
| Signature Catering Coventry Limited | Manufacturing | 2020 |
| Signature FSE Limited | Wholesale & retail | 2003 |
| Signature of London Ltd | Manufacturing | 2017 |
| Signature Support Services Ltd | Health & social care | 2024 |
| Signicon Limited | Information & communication | 2025 |
| Significant Insights Media Ltd | Professional & scientific | 2024 |
| Significant Media Ltd | Information & communication | 2021 |
| Signright Graphics Ltd | Administrative & support | 2002 |
| Sihha Limited | Arts & recreation | 2020 |
| Siip Cafe Ltd | Hospitality | 2026 |
| Sikanian Aljadida Limited | Wholesale & retail | 2023 |
| Sikanya Ltd | Manufacturing | 2023 |
| Sikma Sports Limited | Wholesale & retail | 2017 |
| SIL Consultancy Limited | Professional & scientific | 2006 |
| SIL Secretaries Limited | Administrative & support | 2002 |
| Silbro Consultants Limited | Manufacturing | 2013 |
| Silbus Social Club Limited | Hospitality | 2016 |
| Silea Ltd | Wholesale & retail | 2024 |
| Silicon Biztech Limited | Information & communication | 2018 |
| Silicon Contact Ltd | Manufacturing | 2013 |
| Silk by Seema Ltd | Other services | 2013 |
| Silk London Ltd | Other services | 2018 |
| Silk N Shine Ltd | Other services | 2022 |
| Silos Security Group Ltd | Administrative & support | 2023 |
| Silver Birch Consulting Ltd | Transport & logistics | 2019 |
| Silver Bright Solutions Ltd | Administrative & support | 2017 |
| Silver Bully Solutions Ltd | Manufacturing | 2018 |
| Silver Homes (Northwood) Limited | Construction | 2018 |
| Silver Homes IDG (95 Seabrook) Ltd | Construction | 2020 |
| Silver Homes Residential Ltd | Construction | 2016 |
| Silver Shine Construction Services Limited | Construction | 2017 |