| Sashair Ltd | Other services | 2020 |
| Sashay Away Travel Ltd | Administrative & support | 2019 |
| Sashi Retail Ltd | Wholesale & retail | 2021 |
| Sat-Tech Communications Limited | Information & communication | 1988 |
| Satech Consulting Ltd | Information & communication | 2026 |
| Satellite Events Group Ltd | Wholesale & retail | 2025 |
| Sathya PVT Ltd | Administrative & support | 2025 |
| Sattar Property Group Ltd | Real estate | 2025 |
| Satti Developers Ltd | Construction | 2024 |
| Satyam Store Ltd | Wholesale & retail | 2019 |
| Sauba & Co Limited | Professional & scientific | 2013 |
| Sauba & Daughters Co Limited | Professional & scientific | 2017 |
| Sauba & Partners Limited | Professional & scientific | 2019 |
| Saucy Sausage Cafe Ltd | Hospitality | 2016 |
| Sauizna Europe Ltd | Wholesale & retail | 2019 |
| Saunders Autocare Limited | Wholesale & retail | 2009 |
| Saunders Property Limited | Real estate | 2018 |
| Saunders Strength and Conditioning Ltd | Arts & recreation | 2011 |
| Sava Welding Ltd | Other services | 2019 |
| Savantwerks Limited | Other services | 2025 |
| Save & Smile Ltd | Other services | 2014 |
| Save OUR Environment Limited | Public administration | 2018 |
| Save the David Lean Cinema Campaign CIC | Arts & recreation | 2015 |
| Saved Home and Property Ltd | Transport & logistics | 2021 |
| Saved Property Ltd | Real estate | 2021 |
| Savemore Optical Limited | Health & social care | 2017 |
| Savemore Real Estate Limited | Real estate | 2021 |
| Saverfield Limited | Public administration | 2020 |
| Saveways Wholesale Ltd | Wholesale & retail | 2023 |
| Savio Building Ltd | Construction | 2015 |
| Savio Properties Ltd | Real estate | 2022 |
| Savish Ltd | Wholesale & retail | 2025 |
| Savitha Palanivel Limited | Construction | 2019 |
| Savory Solutions Ltd. | Hospitality | 2025 |
| Savoureux Ltd | Hospitality | 2025 |
| Savoy Court (Camberley) M. C. Limited | Households | 1998 |
| Savoy Surgical Services LLP | | 2011 |
| Savva & Goldstein Ltd | Real estate | 2016 |
| Savvy Hampers Ltd | Wholesale & retail | 2020 |
| Savyell Ltd | Construction | 2024 |
| Sawasdee Flame Co. Limited | Hospitality | 2025 |
| Sawde Property Services Ltd | Other services | 2017 |
| Sawsan & Risaaq Ltd | Education | 2019 |
| Saxon Gate (Chelmsford) Management Company Limited | Households | 2013 |
| Saxonpenny Limited | Information & communication | 2013 |
| Saxonpropertiesuk Ltd | Households | 2025 |
| SAY Nurseries Limited | Health & social care | 2016 |
| SAY Properties Limited | Real estate | 2016 |
| SAY School of Business Ltd | Education | 2019 |
| SAY YES in Italy Ltd | Hospitality | 2023 |
| Sayaw Limited | Education | 2018 |
| Sayvya Limited | Administrative & support | 2025 |
| SB Caterer Ltd | Hospitality | 2022 |
| SB Health Ltd | Health & social care | 2010 |
| SB Learning Hub Ltd | Education | 2023 |
| SB Plus Ltd | Financial services | 2023 |
| SB Private Ltd | Professional & scientific | 2019 |
| SB Removal Ltd | Transport & logistics | 2025 |
| Sbb.Lounge Ltd | Other services | 2026 |
| SBD Care Ltd | Health & social care | 2019 |
| SBF Ltd | Professional & scientific | 2007 |
| SBI Limited | Administrative & support | 2005 |
| SBK Concepts Limited | Hospitality | 2024 |
| SBK Construction Limited | Construction | 2013 |
| SBM Associates Limited | Professional & scientific | 1993 |
| SC & CC Investments Ltd | Real estate | 2023 |
| SC Bikers Ltd | Transport & logistics | 2016 |
| SC Heating Specialists Limited | Manufacturing | 2014 |
| Scafellway Convenience Local Limited | Wholesale & retail | 2018 |
| Scale Accounting Group Ltd | Professional & scientific | 2023 |
| Scalino Limited | Professional & scientific | 2017 |
| Scandinavian Group Limited | Manufacturing | 2012 |
| Scandy Care Limited | Health & social care | 2014 |
| Scaramanga Marketing Limited | Professional & scientific | 2000 |
| SCENIC360 Ltd | Professional & scientific | 2021 |
| Scentrics Information Security Technologies Limited | Information & communication | 2008 |
| Sceptre Court Management Company Limited | Households | 1998 |
| Scheunat Ltd | Wholesale & retail | 2016 |
| Schism Pictures Ltd | Information & communication | 2024 |
| Scholars Place (Bolton) MAN Co Ltd | Households | 2020 |
| Scholars Way (Windle) Management Company Limited | Households | 2008 |
| Schooner Street RTM Company Limited | Households | 2021 |
| SCM Roofing Limited | Construction | 2013 |
| SCM Roofing Specialists Ltd | Construction | 2023 |
| Scorpion Operations Ltd | Administrative & support | 2021 |
| Scotney House RTM Company Limited | Professional & scientific | 2016 |
| Scotpol (UK) Ltd | Construction | 2013 |
| Scott Firth Limited | Arts & recreation | 2007 |
| Scott Stoddart Music Production Ltd | Information & communication | 2024 |
| Scotts Place (Bromley) Residents Management Company Limited | Households | 2016 |
| SCR Coaching Limited | Other services | 2026 |
| Scrace Real Estate Ltd | Real estate | 2021 |
| Scratton Court Management Company Limited | Households | 2010 |
| Screentech Media Ltd | Wholesale & retail | 2015 |
| Scrubhubb Ltd | Administrative & support | 2025 |
| Scrummycrumbs Ltd | Manufacturing | 2024 |
| Sculptamour Ltd | Education | 2022 |
| Sculpted by J Ltd | Other services | 2026 |
| Sculptural Drawings Ltd | Arts & recreation | 2023 |
| Scvr Ltd | Wholesale & retail | 2026 |