| Posturesmart Limited | Administrative & support | 2012 |
| Premium Liquids Group Ltd | Manufacturing | 2022 |
| Premium Liquids Ltd | Wholesale & retail | 2014 |
| Premium Services NE Ltd | Manufacturing | 2017 |
| Prestige Properties NE Ltd | Construction | 2021 |
| Presto Pizza 84 Ltd | Hospitality | 2024 |
| Property Installs Ltd | Professional & scientific | 2025 |
| Proworks NE Holdings Ltd | Professional & scientific | 2017 |
| PW PUB Co Limited | Hospitality | 2019 |
| QR Domestic Plumbing Ltd | Construction | 2026 |
| R.Blakey Groundworks Ltd | Administrative & support | 2022 |
| R.W. Chicken (Scaffolding) Limited | Construction | 2004 |
| R4 Build Limited | Construction | 2024 |
| Raji Properties Ltd | Real estate | 2022 |
| RB Paranormal Events Ltd | Professional & scientific | 2026 |
| RC Event Services Ltd | Arts & recreation | 2020 |
| RD Energy Services Ltd | Construction | 2013 |
| Red Line Boundary Ltd | Real estate | 2023 |
| Red Lion CMT Ltd | Manufacturing | 2018 |
| Red Vine Ltd | Hospitality | 2018 |
| Reece Family Trust | Professional & scientific | 2010 |
| Reforming Pilates Ltd | Wholesale & retail | 2025 |
| Rerumu Limited | Information & communication | 2022 |
| Restoration Conservation Steeplejacks Limited | Construction | 2021 |
| Ridley Groundworks Ltd | Construction | 2021 |
| Rishe's Food Ltd | Wholesale & retail | 2020 |
| Robbie.Ski Ltd | Mining & quarrying | 2025 |
| Robinson Commercial Property Limited | Real estate | 2025 |
| Rooson Properties Ltd | Real estate | 2024 |
| Rosedale Properties & Maintenance Ltd | Real estate | 2025 |
| ROX Fabrication Ltd | Manufacturing | 2021 |
| Royce Carson Building Services Limited | Construction | 2012 |
| RS Northern Salons Limited | Other services | 2025 |
| Ruby Property Solutions Ltd | Real estate | 2020 |
| RW Wellness Ltd | Professional & scientific | 2024 |
| S E R Creative Limited | Professional & scientific | 2013 |
| Safecarelogs Ltd | Information & communication | 2026 |
| SAG Consultancy Ltd | Other services | 2020 |
| SAG Lawyers UK Ltd | Other services | 2024 |
| Sag-Uk Ltd | Information & communication | 2018 |
| SAN D Zins Ltd | Wholesale & retail | 2026 |
| Sapphire Cards TCG Ltd | Wholesale & retail | 2026 |
| Sara Bennett Associates Limited | Real estate | 2015 |
| Sarah Bailey RVN Ltd | Professional & scientific | 2025 |
| SAS Agencies Limited | Administrative & support | 2011 |
| SAY Something Improv CIC | Arts & recreation | 2023 |
| SB Access & Coatings Ltd | Construction | 2016 |
| SBC Builders Ltd | Construction | 2003 |
| Sebacr Limited | Transport & logistics | 2020 |
| Sentential Properties Ltd | Real estate | 2024 |
| Sharpe Safety Ltd | Professional & scientific | 2020 |
| Shift Tech UK Limited | Information & communication | 2020 |
| Shoreline Associates Ltd | Professional & scientific | 2022 |
| Shpubs Ltd | Hospitality | 2023 |
| Singin Hinn Limited | Education | 2021 |
| SJK Access Ltd | Construction | 2015 |
| SJM Transport North East Ltd | Transport & logistics | 2022 |
| Skykal Ltd | Energy | 2019 |
| SL Plastering Limited | Construction | 2025 |
| Smart Energy Products Limited | Professional & scientific | 2009 |
| Smart Mortgage ME Ltd | Financial services | 2020 |
| SN Roofing and Building Limited | Construction | 2025 |
| Snaperture Ltd | Information & communication | 2018 |
| Sonilond Consulting Ltd | Transport & logistics | 2015 |
| Specialist Scaffolding Services Limited | Construction | 2007 |
| Speedo Car Parts Ltd | Wholesale & retail | 2012 |
| Speedy Saddles Limited | Wholesale & retail | 2025 |
| SPS Consultants Ltd | Professional & scientific | 2020 |
| Spyridon Limited | Manufacturing | 2017 |
| Sqlm Ltd | Information & communication | 2018 |
| Srenila Stores Ltd | Wholesale & retail | 2018 |
| Stanley Crook Autos Limited | Wholesale & retail | 2025 |
| Star Building Contractors Limited | Professional & scientific | 2009 |
| Steddie Scaffolding Limited | Construction | 2021 |
| Stewart Haulage (Weardale) Limited | Transport & logistics | 2014 |
| Stoneywood Property Investments Ltd | Real estate | 2023 |
| Stonx Music Ltd | Wholesale & retail | 2025 |
| Stormking Windows Limited | Other services | 1992 |
| Strideglow by KL Ltd | Manufacturing | 2026 |
| Studio Hall Ltd | Professional & scientific | 2018 |
| Stunning Alchemy Projects Ltd | Financial services | 2024 |
| Super Hand Car Wash OS Ltd | Wholesale & retail | 2025 |
| Supreme Adventure Sports Ltd | Arts & recreation | 2016 |
| SW Elite Investments Ltd | Financial services | 2025 |
| Swarm Property Ltd | Real estate | 2025 |
| Sycamore Homes Limited | Construction | 1987 |
| T & I Clark Alcohol Retail Limited | Hospitality | 2025 |
| T.O. Mounter & Sons Holdings Limited | Financial services | 2016 |
| T.O. Mounter & Sons Limited | Manufacturing | 1972 |
| Tail Lamp Enterprises (2021) Limited | Other services | 2021 |
| Tarmacadams Limited | Construction | 2013 |
| Tc&C Holdings Ltd | Financial services | 2026 |
| Team Warrior Taekwondo Ltd | Arts & recreation | 2025 |
| Teerry Limited | Wholesale & retail | 2025 |
| Teeside and Durham Events Ltd. | Administrative & support | 2024 |
| THE Barn Oakenshaw Ltd | Hospitality | 2025 |
| THE Croft NE CIC | Information & communication | 2025 |
| THE Dog House Rules Ltd | Wholesale & retail | 2019 |
| THE Duck Crook Limited | Hospitality | 2024 |
| THE Employee Engagement People Ltd | Administrative & support | 2011 |