| Crook Golf Club Limited | Arts & recreation | 2017 |
| Crook Golf Club Trading Limited | Arts & recreation | 2017 |
| Crook Spice Ltd | Hospitality | 2023 |
| Crook WOK Limited | Hospitality | 2019 |
| Crosby Site Engineers and Surveying Ltd | Professional & scientific | 2022 |
| CSA Consultants Limited | Professional & scientific | 2022 |
| CT Cranes Limited | Manufacturing | 2002 |
| CTS (Care Training Services) Ltd | Other services | 2013 |
| D G LOGISTICS25 Ltd | Transport & logistics | 2025 |
| D W P Plumbing and Heating Ltd | Construction | 2023 |
| D&C GAS Services (NE) Ltd | Construction | 2024 |
| D-Mannose Ltd | Wholesale & retail | 2007 |
| D.E Property Maintenance Ltd | Construction | 2025 |
| D.J.'s Taxis Limited | Transport & logistics | 2014 |
| D1 Fitness & Education Ltd | Arts & recreation | 2023 |
| Dandy Fire Safety and Electrical Services Ltd | Construction | 2026 |
| Danielle’S Agency Ltd | Arts & recreation | 2021 |
| Davidsons Grace Ltd | Professional & scientific | 2013 |
| DBG Offshore Services Limited | Mining & quarrying | 2025 |
| Dbin Ltd | Construction | 2025 |
| Designed by DEN Limited | Manufacturing | 2017 |
| Designer Groundworks Ltd | Administrative & support | 2026 |
| DGI Property Holdings Limited | Real estate | 2013 |
| DGI Property Services Limited | Construction | 2014 |
| DGK Harris Limited | Construction | 2019 |
| Dinkum Income Limited | Real estate | 2023 |
| Direct Distribution Solutions Limited | Transport & logistics | 2018 |
| Dixon Construction Ltd | Construction | 2025 |
| Dldpropertyandhomes Ltd | Real estate | 2025 |
| DMD North East Ltd | Administrative & support | 2022 |
| DN Expert Witness Limited | Health & social care | 2026 |
| Dog Envy Limited | Wholesale & retail | 2023 |
| Dtdt Property Ltd | Real estate | 2022 |
| Ducky's Taxis Ltd | Transport & logistics | 2025 |
| Durham Boiler Maintenance Ltd | Construction | 2017 |
| Durham Community Action Limited | Health & social care | 1936 |
| Durham Dales Homes Limited | Real estate | 2019 |
| Durham Developments Group Limited | Construction | 2023 |
| Durham Developments Limited | Construction | 2001 |
| Durham Electrical Services Limited | Construction | 2009 |
| Durham Property Investments Ltd | Professional & scientific | 2024 |
| DWN Building Ltd | Construction | 2016 |
| Dynamic Property Management North East Limited | Real estate | 2014 |
| E-Lite Blinds Limited | Manufacturing | 2004 |
| E.S.P. Plastics Ltd | Manufacturing | 1985 |
| Eazy Traders Durham Ltd | Wholesale & retail | 2023 |
| Eland Supported Living Ltd | Health & social care | 2023 |
| Electry Ltd | Manufacturing | 2021 |
| Elite Fitness N E Ltd | Arts & recreation | 2018 |
| Ellaleigh Book-Keeping Services Limited | Professional & scientific | 2013 |
| ENG Tech Consulting Ltd | Professional & scientific | 2006 |
| ENV Technology Insulation and Fire Ltd | Public administration | 2021 |
| Environmental Inspection Limited | Construction | 2017 |
| EON Luxfolio Limited | Hospitality | 2020 |
| Eplim Ltd | Extraterritorial | 2013 |
| Estado Limited | Real estate | 2005 |
| Eurowater Limited | Professional & scientific | 1993 |
| Everyone IS... Ltd | Manufacturing | 2017 |
| Evogk Franchise Ltd | Arts & recreation | 2020 |
| Evogk Ltd | Education | 2020 |
| Evolution Goalkeeper Coaching Ltd | Education | 2018 |
| EVT Contractors Limited | Manufacturing | 2002 |
| EVT Group Ltd | Information & communication | 2025 |
| Expertise Ltd | Professional & scientific | 2024 |
| External Walls Ltd | Construction | 2021 |
| F D Hall Ltd | Agriculture & fishing | 2006 |
| F L Hedley & Co Limited | Extraterritorial | 2014 |
| Fabweld Structures Ltd | Manufacturing | 2024 |
| Fair Fabrications & Installations Ltd | Construction | 2026 |
| Fidelity Logistics Limited | Transport & logistics | 2016 |
| Field 489 Limited | Real estate | 2018 |
| FIR Tree Plumbing & Heating Ltd | Construction | 2022 |
| Firmanty & Biggins Limited | Wholesale & retail | 2023 |
| Five Palms ( Positive Attitude Learning Means Success ) Ltd | Education | 2016 |
| Flooring Northeast Limited | Professional & scientific | 2013 |
| Forge Talent Group Ltd | Administrative & support | 2026 |
| Foxtrot Properties Limited | Real estate | 2019 |
| Fred Hayes Ltd | Construction | 2025 |
| G L S Properties Maintenance Ltd | Construction | 2024 |
| Gapps Day Service Ltd | Other services | 2005 |
| Garden Supply Direct Limited | Wholesale & retail | 2005 |
| Gazzt Limited | Information & communication | 2023 |
| General Bucher Court (RTM) Company Ltd | Households | 2018 |
| Geotechnika Ltd | Professional & scientific | 2023 |
| GH Bathrooms Ltd | Construction | 2024 |
| Gibson Surveying and Mapping Limited | Construction | 2010 |
| Gibwill Property Ltd | Real estate | 2024 |
| Ginger X Ltd | Arts & recreation | 2023 |
| Glamorous Nails 77 Limited | Other services | 2022 |
| Glamorous Nails 89 Ltd | Other services | 2025 |
| Go Straight Alignment & Balancing Services Ltd | Wholesale & retail | 2022 |
| Golden Fish Inn Limited | Hospitality | 2024 |
| Goldenfamily Ltd | Hospitality | 2023 |
| Gordon David Byers Ltd | Real estate | 2024 |
| Graeme Hopper Ltd | Arts & recreation | 2015 |
| Graftek Design Limited | Information & communication | 2007 |
| Grant Newton Groundworks Mkii Ltd | Construction | 2024 |
| Grays Aquatic & Pets Limited | Wholesale & retail | 2025 |
| Green Gale Limited | Administrative & support | 2009 |
| Green Property Investment Limited | Real estate | 2012 |