| Rail Competence & Compliance Ltd | Professional & scientific | 2021 |
| Rail Engineering Solutions Group Ltd | Transport & logistics | 2022 |
| Rail Operations Consultancy Limited | Professional & scientific | 2025 |
| Railroader Sports Group CIC | Arts & recreation | 2026 |
| Railway Children Trading Limited | Health & social care | 2008 |
| Rainbow Audio Visual Ltd | Manufacturing | 2008 |
| Rainbow Blinds (Crewe) Limited | Manufacturing | 2011 |
| Rainbow Childcare and Preschool Ltd | Education | 2018 |
| Rainbow Flooring Limited | Construction | 2023 |
| Rainbow Holdings (Crewe) Limited | Financial services | 2019 |
| Rainbow Preschool (Crewe) Ltd | Health & social care | 2019 |
| Rainbow Street Car Wash Ltd | Wholesale & retail | 2024 |
| Rainbowcake Ltd | Wholesale & retail | 2025 |
| Raja's Food Crewe Ltd | Hospitality | 2023 |
| Ralphs Integrated Services Limited | Construction | 2026 |
| Ralugo Ltd | Financial services | 2026 |
| Rampart Games Limited | Information & communication | 2023 |
| Randilow Ltd | Professional & scientific | 2009 |
| Randna Limited | Health & social care | 2025 |
| Range Exchange Limited | Manufacturing | 2013 |
| Ranju Aira Limited | Health & social care | 2025 |
| Ransgroup Limited | Wholesale & retail | 2014 |
| Rapid Healthcare Limited | Administrative & support | 2022 |
| Raptor Residential Ltd | Real estate | 2020 |
| Raspberry Records Limited | Arts & recreation | 2017 |
| Ratis Private Events Ltd | Hospitality | 2023 |
| Ratladi Medical Services Limited | Health & social care | 2013 |
| Raven Electrical Ltd | Construction | 2019 |
| Raven Trading North Western Ltd | Hospitality | 2022 |
| Ravenscroft Renovations Ltd | Administrative & support | 2022 |
| Ravio Ltd | Construction | 2020 |
| Ravo Health Care Limited | Health & social care | 2025 |
| RAW CON Commercial Ltd | Construction | 2025 |
| Rawcus Social Media Management Limited | Information & communication | 2015 |
| Rawhan Holdings Ltd | Financial services | 2025 |
| Rawlinson Construction Limited | Construction | 2015 |
| RAY Twiss Motors Limited | Wholesale & retail | 2002 |
| Rayertech Limited | Information & communication | 2019 |
| Rayjohn Limited | Administrative & support | 2022 |
| Razvan WRC Limited | Information & communication | 2025 |
| Rbuk Limited | Professional & scientific | 2016 |
| RC Long Buckby Ltd | Health & social care | 2017 |
| RCD Marine Services Ltd | Professional & scientific | 2025 |
| RCN Trans Ltd | Transport & logistics | 2019 |
| Rcrx Limited | Arts & recreation | 2025 |
| RD Disposal Limited | Wholesale & retail | 2016 |
| RD Engineering (Cheshire) Limited | Construction | 2019 |
| RD Music Service Limited | Arts & recreation | 2026 |
| RDH Cheshire Services Ltd | Wholesale & retail | 2010 |
| RDI RS Limited | Transport & logistics | 2024 |
| RDS Vehicle Services Ltd | Wholesale & retail | 2016 |
| React Development Management Services Ltd | Professional & scientific | 2015 |
| Reactive Audio Limited | Professional & scientific | 2001 |
| Read Holdings (UK) Limited | Professional & scientific | 2012 |
| Ready Office Limited | Professional & scientific | 2025 |
| Real Life Learning Limited | Administrative & support | 2022 |
| Rebecca Holland Consultancy Limited | Professional & scientific | 2012 |
| REC2REC Solutions Ltd | Other services | 2017 |
| RECIPROC8 Telecommunications Limited | Water & waste | 2009 |
| Reckee Ltd | Administrative & support | 2024 |
| Recoded Solutions Ltd | Information & communication | 2022 |
| Recoup Business Support Centre Limited | Professional & scientific | 2019 |
| Recoup Financial Solutions Limited | Financial services | 2025 |
| Recoup Holdings Limited | Professional & scientific | 2022 |
| Red Bird Enterprises Ltd | Wholesale & retail | 2024 |
| Red Box Surveys Limited | Professional & scientific | 2010 |
| Red Carpet Properties Ltd. | Administrative & support | 2007 |
| Red Eleven Consulting Limited | Professional & scientific | 2020 |
| Red Lobster Solutions Limited | Information & communication | 2013 |
| Red Rock Controls Limited | Professional & scientific | 2013 |
| Red Scope Cheshire Ltd | Professional & scientific | 2025 |
| Redhu Enterprises Limited | Wholesale & retail | 2024 |
| Redland Care Holdings Limited | Health & social care | 2018 |
| Redstone Technology Ltd | Information & communication | 2013 |
| Reeves Branding Limited | Other services | 2009 |
| Reeves Productions Ltd | Information & communication | 2022 |
| Refresh Hot TUB Servicing Ltd | Administrative & support | 2022 |
| Regal Sparkle Cleaning Services Ltd | Administrative & support | 2025 |
| Regent Management Solutions Limited | Real estate | 2024 |
| Regent Property Solutions Limited | Real estate | 2016 |
| Regional Transport Solutions Ltd | Transport & logistics | 2020 |
| Regulatory Facilitation Company Limited | Professional & scientific | 2006 |
| Rehder Consulting Limited | Information & communication | 2026 |
| Reid Group Ltd | Real estate | 2026 |
| Rekkids Limited | Wholesale & retail | 2018 |
| Relevé Limited | Wholesale & retail | 2026 |
| Reliable Driver Solutions Ltd | Administrative & support | 2015 |
| Relished Limited | Hospitality | 2003 |
| Remer Street Auto Paint Shop Ltd | Wholesale & retail | 2026 |
| Remer Street MOT & Repairs Ltd | Wholesale & retail | 2026 |
| Remer Street Tyre Service Ltd | Wholesale & retail | 2026 |
| Remtco Limited | Information & communication | 2005 |
| Rena’S Property Group Ltd | Real estate | 2025 |
| Render Investments Limited | Real estate | 2019 |
| Rendezvous END Ltd | Professional & scientific | 2023 |
| Renew Crewe West Limited | Manufacturing | 2019 |
| Renew Design & Marketing Limited | Professional & scientific | 2014 |
| Renew Land Audlem Limited | Real estate | 2018 |
| Renew Land Baldwins Gate Limited | Real estate | 2018 |
| Renew Land Construction Limited | Construction | 2014 |