| Engaging Automotive Consultancy Ltd | Wholesale & retail | 2022 |
| Engauged Limited | Professional & scientific | 2011 |
| Engine of the North Limited | Professional & scientific | 2013 |
| Engineering Maintenance Supplies Limited | Wholesale & retail | 2021 |
| Engineering Management & Plant Ltd | Construction | 2020 |
| Englesea Court Management Company Limited | Households | 2009 |
| Enrgy Group Limited | Construction | 2016 |
| Enrgy Limited | Professional & scientific | 2014 |
| Enrgy Project Services Limited | Professional & scientific | 2017 |
| Enrgy Services Limited | Professional & scientific | 2016 |
| Enright Build Limited | Construction | 2017 |
| Entertainment Crewe Ltd | Hospitality | 2025 |
| Entertainment Pass Ltd | Administrative & support | 2025 |
| Entire Contracts Limited | Construction | 2013 |
| Entrymaster Limited | Professional & scientific | 2008 |
| Enviro Care Waste Solutions Ltd | Water & waste | 2016 |
| Enviro Skip Hire Group Ltd | Transport & logistics | 2018 |
| Environment Awareness | Education | 2024 |
| Environmental Solutions (Cheshire) Limited | Professional & scientific | 2013 |
| Enviroscaping T/A Little & Large Landscapes Ltd | Administrative & support | 2014 |
| Envoera Limited | Professional & scientific | 2020 |
| EO Distribution Limited | Wholesale & retail | 2019 |
| EPH Electrical Services Limited | Construction | 2026 |
| Epidrasis Strategic Communications Ltd | Professional & scientific | 2025 |
| EPR Holdings Ltd | Financial services | 2026 |
| Equiform Nutrition Limited | Financial services | 2009 |
| ERA Creative Limited | Professional & scientific | 2011 |
| ERA Theatrical Productions Ltd | Arts & recreation | 2024 |
| Ergovas Ltd | Construction | 2020 |
| Eruh Property Investments Limited | Real estate | 2023 |
| ESH Rail Services Ltd | Construction | 2023 |
| Esrem Holdings Limited | Real estate | 2021 |
| Esrem Limited | Construction | 2018 |
| Essential GMP Services Limited | Manufacturing | 2012 |
| Essentials - Subscription Boxes Limited | Wholesale & retail | 2024 |
| Eternal Brickwork and Pointing Ltd | Construction | 2025 |
| Ethersec Industries Ltd | Information & communication | 2001 |
| EUM Healthcare Ltd | Health & social care | 2023 |
| Euro Caps and Closures Limited | Administrative & support | 2015 |
| European Diesel Card Limited | Wholesale & retail | 2005 |
| European Life-Science Academy Limited | Administrative & support | 2013 |
| Evabell Properties Ltd. | Real estate | 2020 |
| Evans Building Consultancy Limited | Professional & scientific | 2020 |
| Evans Realty Solutions Ltd | Real estate | 2025 |
| Event Fridges Ltd | Hospitality | 2025 |
| Event Refuelling Services Ltd | Wholesale & retail | 2025 |
| Ever Green Buy Ltd | Wholesale & retail | 2025 |
| Evering Limited | Construction | 2006 |
| Everything Connected Limited | Wholesale & retail | 2014 |
| Everything Ecommerce Ltd | Wholesale & retail | 2021 |
| EVO Plus Consulting Limited | Information & communication | 2023 |
| Evocore Innovations Limited | Manufacturing | 2025 |
| Evolve Family Law (EOT) Ltd | Administrative & support | 2021 |
| Evolve Family Law Ltd | Professional & scientific | 2015 |
| Evolve FM Limited | Construction | 2025 |
| Evolving Care Limited | Health & social care | 2012 |
| Excelvent Solutions Ltd | Professional & scientific | 2014 |
| Exchange Keys Limited | Professional & scientific | 2020 |
| Excorald Scanning Ltd | Health & social care | 2026 |
| Expatriate Relocation Limited | Professional & scientific | 1999 |
| Expert Ondemand Limited | Information & communication | 2019 |
| Explore Off-Road Ltd | Education | 2018 |
| Explore With Ellen Limited | Administrative & support | 2025 |
| Expo Events Limited | Administrative & support | 2006 |
| Exposure Photo Marketing Limited | Extraterritorial | 2018 |
| Express Supermarket Crewe Ltd | Wholesale & retail | 2025 |
| EXPRESSWAY55 (Deeside) Limited | Real estate | 2013 |
| Exterior Cleaning Association | Other services | 2025 |
| Ezee Kleen Limited | Administrative & support | 2014 |
| Ezytech Limited | Wholesale & retail | 2021 |
| F & a Homes Ltd | Real estate | 2026 |
| F L Agri Ltd | Transport & logistics | 2020 |
| F1RST Group Solutions Ltd | Administrative & support | 2015 |
| FAB Social Care Limited | Health & social care | 2022 |
| Fabulash Limited | Other services | 2014 |
| Fairforallnw Limited | Professional & scientific | 2025 |
| Famealie Limited | Information & communication | 2024 |
| Family Search Limited | Extraterritorial | 2013 |
| Family Ties CIC | Administrative & support | 2016 |
| Fanis Facilities Management Limited | Administrative & support | 2007 |
| Faraway Shores Travel Ltd | Administrative & support | 2023 |
| Farm FUN Limited | Arts & recreation | 2018 |
| Farm IT Ltd | Agriculture & fishing | 2016 |
| Farms on Track Ltd | Agriculture & fishing | 2014 |
| Farrell Barrells Ltd | Hospitality | 2025 |
| Farsorest Developments Limited | Real estate | 1966 |
| Fashion Boutique CRW Ltd | Wholesale & retail | 2023 |
| Fast Deal Technology Limited | Wholesale & retail | 2016 |
| Fast Fabian Solutions Limited | Transport & logistics | 2020 |
| Fast House Buyers Limited | Construction | 2025 |
| Fast House Investments Limited | Real estate | 2026 |
| Fast Mail Tackle Ltd | Wholesale & retail | 2023 |
| Fast Track BIO Ltd | Professional & scientific | 2021 |
| Fastco (Fasteners & Fixings) Limited | Wholesale & retail | 1999 |
| Fasttent Ltd | Construction | 2019 |
| FAT Cat Platters Limited | Hospitality | 2024 |
| Fayrefield Foods Limited | Wholesale & retail | 1982 |
| Fayrefield Ingredients Limited | Hospitality | 2008 |
| Fayrefield Nutratek Limited | Wholesale & retail | 2025 |
| FCB Manual Therapy Ltd | Other services | 2021 |