| Decharge Ltd | Water & waste | 2021 |
| Decorate SW Ltd | Construction | 2023 |
| Delta Ground Anchors Limited | Manufacturing | 2002 |
| Demesne Gretan Limited | Professional & scientific | 2015 |
| Devon Biofuels Limited | Administrative & support | 2010 |
| Devon Bricklayers Limited | Construction | 2017 |
| Devon Bricklaying Limited | Construction | 2017 |
| Devon Building Contractors Limited | Construction | 2016 |
| Devon Car Storage Ltd | Transport & logistics | 2017 |
| Devon Concrete Limited | Manufacturing | 2011 |
| Devon Country Pursuits Limited | Administrative & support | 2014 |
| Devon Curry Limited | Hospitality | 2018 |
| Devon Dairy Brands | Manufacturing | 2021 |
| Devon Dairy Vets Ltd | Professional & scientific | 2025 |
| Devon Electrical Solutions Limited | Construction | 2023 |
| Devon Energy Partnership Limited | Administrative & support | 2016 |
| Devon Energy Surveyors Ltd | Households | 2024 |
| Devon Group Limited | Construction | 2015 |
| Devon Hedgelayer Ltd | Administrative & support | 2023 |
| Devon Helping Hands Ltd | Administrative & support | 2023 |
| Devon Lettings Limited | Real estate | 1995 |
| Devon Mediation Service Limited | Other services | 1997 |
| Devon Pathways Ltd | Education | 2021 |
| Devon Ready MIX Concrete Ltd | Manufacturing | 2020 |
| Devon RIM Company Limited | Manufacturing | 2004 |
| Devon Roofing Ltd | Construction | 2023 |
| Devon Rusk Company Limited | Manufacturing | 2022 |
| Devon Shepherd Huts Limited | Hospitality | 2015 |
| Devonoak Ltd | Manufacturing | 2010 |
| Dfec Limited | Construction | 2015 |
| Dharma Construction Consultancy Services Ltd | Construction | 2022 |
| Diamond Doorway Academy Ltd | Information & communication | 2018 |
| Diddy Films Ltd | Information & communication | 2011 |
| Digicolor Print Limited | Manufacturing | 2024 |
| Digital Wilbur Ltd | Professional & scientific | 2021 |
| Dingle Design Ltd | Manufacturing | 2015 |
| Dingle Ltd | Administrative & support | 2025 |
| DJK (2015) Limited | Manufacturing | 2015 |
| DJK (Crediton) Limited | Construction | 2000 |
| Dma-Phe Limited | Professional & scientific | 2016 |
| DMK Plant Services Limited | Construction | 2017 |
| DMS Trading Ltd | Wholesale & retail | 2009 |
| DNA Valeting Ltd | Wholesale & retail | 2025 |
| Dobel Construction Services Limited | Professional & scientific | 2012 |
| Doggamarsh Properties Limited | Real estate | 2010 |
| DPW QS Services Ltd | Professional & scientific | 2024 |
| Driftworld Limited | Professional & scientific | 1997 |
| DSM Sewage Plant Limited | Households | 2010 |
| Duncan Churchill & Co Ltd | Professional & scientific | 2009 |
| Dynamic Data Consulting Limited | Information & communication | 2008 |
| Dynamic Servers Limited | Information & communication | 2017 |
| E 32 Limited | Real estate | 2003 |
| E H Frost & SON Limited | Construction | 2003 |
| E J Yeandle Plumbing & Heating Limited | Construction | 2015 |
| Eakers Ltd | Wholesale & retail | 2024 |
| Eastern Images Limited | Professional & scientific | 2009 |
| Easthay Ltd | Real estate | 2025 |
| Eastington Holiday Rentals Ltd | Real estate | 2025 |
| Eastridge Energy Limited | Energy | 2011 |
| Eastwood Racing Limited | Manufacturing | 2024 |
| Eco Lelu Ltd | Wholesale & retail | 2020 |
| ED Rogers Landscape Construction and Maintenance Limited | Other services | 2013 |
| Edward Claye Limited | Manufacturing | 2011 |
| Edwin FOX Foundation | Professional & scientific | 2000 |
| Edwin Tucker & Sons Limited | Wholesale & retail | 1899 |
| Edworthy Group Limited | Financial services | 2022 |
| Edworthy Media and Technology Limited | Wholesale & retail | 2010 |
| Edworthys Concrete Limited | Manufacturing | 1986 |
| Efford Precison Ltd | Manufacturing | 2025 |
| Elava Groundworks Limited | Construction | 2015 |
| Elbury Properties Limited | Construction | 2004 |
| Elements Marketing Ltd | Professional & scientific | 2021 |
| Elite Mobile Event Bars Limited | Hospitality | 2013 |
| Elmley Foundation(The) | Arts & recreation | 1985 |
| Empowering Girls South West CIC | Health & social care | 2025 |
| EMS (Devon) Ltd | Construction | 2015 |
| Endpoint Property Ltd | Real estate | 2025 |
| Endpoint. Projects Ltd | Information & communication | 2011 |
| Enflingo Global Ltd | Professional & scientific | 2021 |
| Epitome South West Ltd | Information & communication | 2020 |
| Equality Access Consultants Ltd | Professional & scientific | 2025 |
| Equitotal Ltd | Professional & scientific | 2014 |
| Esmos Ltd | Manufacturing | 2012 |
| Eva's Restaurant Ltd | Hospitality | 2023 |
| Event Doctor Medical Services Ltd | Health & social care | 2026 |
| Events by M Ltd | Professional & scientific | 2026 |
| EX17 Limited | Construction | 2010 |
| EX3TER Limited | Real estate | 2009 |
| EXE Valley Car Sales Ltd | Wholesale & retail | 2021 |
| EXE Valley Fuels Limited | Other services | 2004 |
| Exeter Chiropractic Clinic Limited | Health & social care | 2013 |
| Exeter Friend Ltd | Other services | 2023 |
| Exeter Karting Limited | Arts & recreation | 2021 |
| Exeter Laser and Advanced Skincare Limited | Health & social care | 2018 |
| Exeter Motorcycle Tyre Centre Ltd | Wholesale & retail | 2022 |
| Exeter Quads LLP | | 2017 |
| Exlg Catering Limited | Hospitality | 2025 |
| Exlpd Ltd | Professional & scientific | 2024 |
| Expert-Net (UK) Limited | Information & communication | 1998 |
| Express Cars Exeter Limited | Transport & logistics | 2012 |