| Shoobridge Funeral Services Limited | Other services | 2019 |
| Shoreside Business Consultancy Limited | Professional & scientific | 2018 |
| Showpiece (Devon) Limited | Agriculture & fishing | 2003 |
| Side Projects (BG) Limited | Arts & recreation | 2017 |
| Simon Roper Ltd | Education | 2008 |
| Simply Accounting Solutions Ltd | Professional & scientific | 2019 |
| SIXT4 Ltd | Hospitality | 2016 |
| SK Gymnastics Ltd | Arts & recreation | 2025 |
| Skruffy Records Limited | Manufacturing | 2026 |
| SLF Transport Services Limited | Transport & logistics | 2017 |
| Smarter Accounting Limited | Professional & scientific | 2016 |
| Smarter Accounting Services Limited | Professional & scientific | 2006 |
| Smarter Bookkeeping Limited | Professional & scientific | 2016 |
| Smartworld Body Repairs Limited | Wholesale & retail | 2013 |
| Smile More Productions Ltd | Professional & scientific | 2024 |
| SML Photography Ltd | Professional & scientific | 2011 |
| Smoking Embers Ltd | Hospitality | 2023 |
| SOL Plaatje Educational Project | Professional & scientific | 1983 |
| Soloarc Limited | Professional & scientific | 2022 |
| Somerset Engineering Ltd | Professional & scientific | 2023 |
| Somerset Partnership Arts Education Agency | Education | 2000 |
| Soulsome Chocolate Ltd | Manufacturing | 2021 |
| Sound in Theory Limited | Information & communication | 2004 |
| South Beer Barns Management Company Limited | Households | 2005 |
| South Coast Cutting Room Ltd | Information & communication | 2025 |
| South Wales and South West Roofing Training Group | Education | 1999 |
| South West Heritage & Development Ltd | Construction | 2025 |
| South West Refrigeration Limited | Manufacturing | 1983 |
| South Wonston Stores Ltd | Wholesale & retail | 2012 |
| Southdown Engineering Services Limited | Professional & scientific | 2022 |
| Southmoor Farm Limited | Agriculture & fishing | 2003 |
| Southmoor Farm Machinery Limited | Wholesale & retail | 2007 |
| Southwest Interiors Ltd | Manufacturing | 2019 |
| Southwest Activities Limited | Arts & recreation | 2021 |
| Southwood Supplies Ltd | Wholesale & retail | 2025 |
| Sowdens Farm Contracting Limited | Agriculture & fishing | 2016 |
| Sowdens Farm Limited | Agriculture & fishing | 2004 |
| Space Value Foundation | Information & communication | 2022 |
| Space Value Ltd | Professional & scientific | 2022 |
| Spectex Ltd | Real estate | 2021 |
| Spence Scaffolding Limited | Construction | 2019 |
| Spinal Research Foundation | Health & social care | 1990 |
| Sportskitsolutions Limited | Wholesale & retail | 2015 |
| SPS Consulting (SW) Ltd | Professional & scientific | 2014 |
| Squid (Sensible) Limited | Arts & recreation | 2008 |
| Srts Limited | Transport & logistics | 2006 |
| ST Boniface Psychology Services Ltd | Health & social care | 2022 |
| ST Boniface Veterinary Clinic Limited | Professional & scientific | 2005 |
| Standon Holsteins Limited | Agriculture & fishing | 2008 |
| Stapletons Accountants Limited | Professional & scientific | 2017 |
| Star Legal (Devon) Limited | Professional & scientific | 2014 |
| Startup AI Ltd | Information & communication | 2025 |
| Stay at Hayne Limited | Hospitality | 2022 |
| Stellenbosch University SA Foundation UK | Professional & scientific | 2004 |
| Steven Leach Building Services Ltd | Administrative & support | 2015 |
| STK Heating and Plumbing Ltd | Construction | 2023 |
| Stockleigh Properties Limited | Construction | 2020 |
| Stone & Stone Developments Ltd | Construction | 2026 |
| Stones Steakhouse Ltd | Hospitality | 2025 |
| Stop Digging South West Limited | Construction | 2019 |
| Stove Centre South Molton Ltd | Wholesale & retail | 2023 |
| Stowpro Limited | Wholesale & retail | 2026 |
| Stoyle & Adamson Ltd | Professional & scientific | 2001 |
| Straight Talk Consulting Limited | Professional & scientific | 2007 |
| Stuart Gelson Limited | Transport & logistics | 2022 |
| Studio Every Ltd | Professional & scientific | 2022 |
| Subtle Automotive Ltd | Professional & scientific | 2020 |
| Summerhayes Care Home Limited | Health & social care | 2011 |
| Sundays (Exeter) Ltd | Hospitality | 2022 |
| Sunrise Dent Ltd | Health & social care | 2025 |
| Surfplugs Limited | Manufacturing | 2015 |
| Sutherland Specialist Security Ltd | Administrative & support | 2014 |
| Sutton & Cavill Decorating Limited | Construction | 2017 |
| Sutton GAS Ltd | Construction | 2023 |
| SW Finishings Ltd | Construction | 2024 |
| Sweepmain Limited | Agriculture & fishing | 1997 |
| Swift Air Solutions Ltd | Construction | 2010 |
| SWT Contractors Ltd | Construction | 2024 |
| Sylvan Developments (South West) Limited | Construction | 1996 |
| Sylvan Holdings Limited | Professional & scientific | 1996 |
| Sylvan Southwest Ltd | Professional & scientific | 2025 |
| Synergic Software Ltd | Information & communication | 2022 |
| T H Brickworks Limited | Construction | 2022 |
| T J Thurgood Limited | Other services | 2024 |
| T P Wainwright Limited | Construction | 2003 |
| T.G.W Building Services Ltd | Construction | 2018 |
| Tailored & MAT Supplies (Devon) Ltd | Manufacturing | 2009 |
| Tailored Optical Ltd | Manufacturing | 2022 |
| Tanner & Bruce Limited | Construction | 2003 |
| Tanner & Bruce Plant Limited | Construction | 2017 |
| Tattva Limited | Professional & scientific | 2024 |
| Taylor Plant Training Ltd | Construction | 2024 |
| Taylormade Plumbing & Heating (SW) Ltd | Construction | 2020 |
| TCL (SW) Ltd | Financial services | 2026 |
| TDH Building Services Ltd | Construction | 2016 |
| Technical Films Ltd | Manufacturing | 2018 |
| Technical Solutions (SW) Limited | Financial services | 2018 |
| Technical Support Services South West Limited | Manufacturing | 1997 |
| Tekmoni Limited | Information & communication | 2023 |
| Terra NRG Limited | Professional & scientific | 2022 |