| Skydeco Ltd | Construction | 2015 |
| Skye Global Ltd | Hospitality | 2020 |
| Skygem Properties Limited | Construction | 2003 |
| Skylux Travel Extras Ltd | Professional & scientific | 2017 |
| Skymode Properties Limited | Real estate | 2007 |
| Skypurity Ltd | Wholesale & retail | 2026 |
| Skyward Aviation Ltd | Transport & logistics | 2020 |
| SL Enterprises Ltd | Administrative & support | 2018 |
| Slawter Studios Ltd | Information & communication | 2019 |
| Slayy by Wendy Ltd | Other services | 2025 |
| SLB UK II Limited | Professional & scientific | 1977 |
| SLC Academy Ltd | Education | 2026 |
| SLG Technical Services Limited | Information & communication | 2002 |
| Slik Ltd | Hospitality | 2025 |
| Slikg Limited | Health & social care | 2022 |
| SLV Motor Company Ltd | Wholesale & retail | 2022 |
| Smallfield Insurance Services Limited | Financial services | 2003 |
| Smallfields Limited | Real estate | 2020 |
| Smarct Limited | Information & communication | 2024 |
| Smart 365 Solutions Limited | Information & communication | 2026 |
| Smart Airport Travel Ltd | Transport & logistics | 2019 |
| Smart Aviation Limited | Transport & logistics | 2005 |
| Smart Body and Performance Ltd | Health & social care | 2022 |
| Smart Cleaning Services PVT Limited | Administrative & support | 2026 |
| Smart Extract Ltd | Construction | 2025 |
| Smart Fashion Holdings (UK) Limited | Extraterritorial | 2014 |
| Smart in Business Limited | Professional & scientific | 2015 |
| Smart Signs Solutions Ltd | Manufacturing | 2024 |
| Smart Value Property Ltd | Real estate | 2024 |
| Smartbiz Consultants Ltd | Information & communication | 2016 |
| Smartbiz Solutions Ltd | Information & communication | 2019 |
| Smartmart Ltd | Wholesale & retail | 2025 |
| Smartstay Property Solutions Ltd | Real estate | 2026 |
| Smartt Gym Crawley Limited | Arts & recreation | 2025 |
| Smashed Bro's Ltd | Hospitality | 2023 |
| Smcathy Business Consults Limited | Administrative & support | 2016 |
| SME Studios Ltd | Information & communication | 2026 |
| Smeets Ferry Traders Ltd | Hospitality | 2024 |
| Smiben UK Limited | Mining & quarrying | 2004 |
| Smile Design Print & Digital Ltd | Professional & scientific | 2018 |
| Smoke Control Solutions Limited | Manufacturing | 2006 |
| Smooth Connect Ltd | Transport & logistics | 2024 |
| Smoothline Properties Ltd | Real estate | 2026 |
| SN Actuarial Services Limited | Professional & scientific | 2019 |
| SN Beauty Clinic Ltd | Manufacturing | 2018 |
| SN Blackwell Limited | Professional & scientific | 2019 |
| SN Smart Mart Limited | Wholesale & retail | 2025 |
| Snailsss Ltd | Other services | 2025 |
| Snapkart Ltd | Wholesale & retail | 2025 |
| Snippy Crab Games Ltd | Information & communication | 2024 |
| Snowdon Partnership Ltd | Professional & scientific | 2025 |
| SNS Repair Services Ltd | Wholesale & retail | 2022 |
| SO Circus Academy Ltd | Education | 2024 |
| SO KEE Ltd | Hospitality | 2024 |
| Sober Camp CIC | Health & social care | 2025 |
| Sober Viking Ltd | Wholesale & retail | 2025 |
| Socia-Ball Sports Club Ltd | Arts & recreation | 2025 |
| Sofiane Services Limited | Construction | 2025 |
| Soft Data Ltd | Wholesale & retail | 2026 |
| Soft Ice UK Ltd | Wholesale & retail | 2025 |
| Software Concepts Limited | Manufacturing | 2022 |
| Sogari Solutions Ltd | Transport & logistics | 2024 |
| Sohaib AR Ltd | Information & communication | 2025 |
| Soja Group Ltd | Administrative & support | 2017 |
| Soke Accounting Ltd | Professional & scientific | 2023 |
| Solani Collective Ltd. | Information & communication | 2022 |
| Soldan Ltd | Wholesale & retail | 2025 |
| Solea Beauty Ltd | Other services | 2018 |
| Solutech Electrical Ltd | Construction | 2017 |
| Solution Chapel International Limited | Other services | 2009 |
| Solvable Ltd | Information & communication | 2024 |
| Soly Logistics Ltd | Transport & logistics | 2019 |
| Solymar Ltd | Professional & scientific | 2023 |
| Somaya Ltd | Real estate | 2021 |
| Something Wiccan Ltd | Wholesale & retail | 2019 |
| Sonia Courier Ltd | Transport & logistics | 2022 |
| Sonic Safeguarding Limited | Administrative & support | 2026 |
| Sonic.Aero Limited | Information & communication | 2012 |
| Sonny's Sweeping Ltd | Water & waste | 2014 |
| Sono International Ltd | Administrative & support | 2010 |
| Sony Consultancy Bi̇li̇şi̇m Danişmanlik Limited | Other services | 2018 |
| Soon Care Limited | Health & social care | 2024 |
| Soper Home Limited | Construction | 2015 |
| Sophia & Dany Ltd | Other services | 2020 |
| SORTED247 Limited | Transport & logistics | 2024 |
| SOS Discovery Limited | Information & communication | 2023 |
| SOS Systems Holdings Ltd | Financial services | 2021 |
| SOS Wholesale Holdings Ltd | Financial services | 2021 |
| Soso Haulage Ltd | Transport & logistics | 2019 |
| Sotam Limited | Real estate | 2024 |
| Soul Shutters Ltd | Other services | 2018 |
| Soulcare & Support Ltd | Administrative & support | 2025 |
| Soulful Verse Ltd | Wholesale & retail | 2025 |
| Sound Style Limited | Information & communication | 2017 |
| Source Code Academia Ltd | Transport & logistics | 2024 |
| South Anglia Roof Repairs Ltd | Construction | 2025 |
| South Cliff (Kent) Limited | Financial services | 2018 |
| South Cliff Limited | Health & social care | 2012 |
| South Down Dental Care Limited | Health & social care | 2011 |
| South Downs Building Surveys Ltd | Professional & scientific | 2023 |