| Saii Store Ltd | Wholesale & retail | 2023 |
| Saint Mary Locums Limited | Health & social care | 2018 |
| SAJ K Ltd | Other services | 2024 |
| Sandwell Accountancy Services Limited | Professional & scientific | 1991 |
| Sandwell Valley Amusements Limited | Arts & recreation | 2019 |
| Sandylicious Bakes Ltd | Hospitality | 2020 |
| SAR Telecom Services Ltd | Construction | 2023 |
| Sara MIB Ltd | Transport & logistics | 2019 |
| Saries Limited | Real estate | 2014 |
| Saunders Repair Services Limited | Wholesale & retail | 2022 |
| Sazzle Limited | Information & communication | 2017 |
| SB Trading (UK) Limited | Wholesale & retail | 2013 |
| Scaffoldmart Ltd | Wholesale & retail | 2024 |
| Scholarsink Limited | Administrative & support | 2014 |
| Scratch Solutions Limited | Wholesale & retail | 2016 |
| Scriven & Thornton Fine Foods Limited | Wholesale & retail | 2014 |
| Scriven & Thornton Holdings Limited | Professional & scientific | 2016 |
| SCW Resources Limited | Professional & scientific | 2023 |
| SEC Contractors Limited | Construction | 2017 |
| Second City Attractions Limited | Arts & recreation | 2023 |
| Secp Contractors Limited | Construction | 2026 |
| Secure Zone Security Ltd | Public administration | 2020 |
| Security 247 Ltd | Administrative & support | 2017 |
| SEE Seehra Limited | Wholesale & retail | 2009 |
| Sego Limited | Real estate | 2026 |
| Semvero Limited | Information & communication | 2025 |
| Send Music UK Ltd | Education | 2026 |
| Sendmoi Ltd | Information & communication | 2024 |
| Sentinel Plastics Limited | Manufacturing | 1989 |
| Septimus Services Ltd | Public administration | 2024 |
| Serenity Healthcare (Midlands) Limited | Health & social care | 2016 |
| Setek Ltd | Hospitality | 2025 |
| Seth Bradbury Tree Services Ltd | Agriculture & fishing | 2014 |
| SH Service Centre Ltd | Wholesale & retail | 2025 |
| Shadbolt Rope Access Limited | Administrative & support | 2005 |
| Shafqat Enterprises Ltd | Wholesale & retail | 2014 |
| Shah's Land Ltd | Hospitality | 2026 |
| Shahmir Ltd | Wholesale & retail | 2026 |
| Shakespeare Forgings Limited | Manufacturing | 2001 |
| Shammah Boutik Ltd | Wholesale & retail | 2025 |
| Share Roofing Limited | Construction | 2021 |
| Sheppard Morrall Services Limited | Construction | 2005 |
| Sheriff and Penny Private Bailiffs Limited | Administrative & support | 2003 |
| Shersci Ltd | Information & communication | 2023 |
| Shine Nursery Limited | Health & social care | 2016 |
| Shiraz Academy Ltd | Education | 2025 |
| Shoes 4 Youuu Ltd | Wholesale & retail | 2022 |
| SHR Access Management Ltd | Real estate | 2026 |
| Shropshire Catering Limited | Hospitality | 2025 |
| Shropshire Country Taverns Limited | Hospitality | 2024 |
| Shropshire Inns and Bars Limited | Hospitality | 2012 |
| Sierra 57 Consult Limited | Professional & scientific | 2019 |
| Sigma Consultancy & Data Services Ltd | Information & communication | 2021 |
| Sign Wizards Ltd | Manufacturing | 2012 |
| Signline Limited | Administrative & support | 2005 |
| Siha Health Limited | Health & social care | 2024 |
| Simplified Safety Limited | Wholesale & retail | 2009 |
| Simpsons Pizza Ltd | Hospitality | 2023 |
| Sing Fung 68 Limited | Hospitality | 2026 |
| SINGULARITY12GO Ltd | Transport & logistics | 2025 |
| Sire Ventures 1 Limited | Real estate | 2023 |
| Siteworks 2000 Limited | Administrative & support | 2000 |
| Sixn Ltd | Wholesale & retail | 2025 |
| Sixteen a Dental Care Limited | Health & social care | 2011 |
| Sizzling Grill (Midlands) Limited | Hospitality | 2015 |
| SJ Catering (Midlands) Limited | Hospitality | 2016 |
| Skiniq Limited | Other services | 2018 |
| Smart Catering Repairs Ltd | Other services | 2016 |
| Smart Guide Ltd | Education | 2024 |
| Smart Parcel Box Limited | Wholesale & retail | 2019 |
| Smart Safe Solutions Ltd | Administrative & support | 2023 |
| Smart Supply Services Limited | Wholesale & retail | 2026 |
| Smartflex Ltd | Information & communication | 2025 |
| Smarts Laundry Service Ltd. | Other services | 2014 |
| SMB Autocentre (Midlands) Limited | Wholesale & retail | 2018 |
| SMB Raceway Ltd | Wholesale & retail | 2025 |
| Smidr Trans Limited | Transport & logistics | 2023 |
| Smile Labs UK Limited | Manufacturing | 2014 |
| Smile Productions CIC | Arts & recreation | 2023 |
| Smith Business Insights Ltd | Information & communication | 2024 |
| Smithsprintingstudio Ltd | Professional & scientific | 2025 |
| Snap Flooring Ltd | Wholesale & retail | 2025 |
| Snooks Snooker Club Limited | Hospitality | 2011 |
| SNP Trading Ltd | Extraterritorial | 2011 |
| SO Leisure Limited | Arts & recreation | 2016 |
| Solus Properties Limited | Real estate | 2017 |
| Sophiax Ltd | Construction | 2018 |
| SP One Properties Limited | Real estate | 2021 |
| Sparcle Wash Ltd | Administrative & support | 2025 |
| Speech Therapy West Midlands Ltd | Health & social care | 2012 |
| Sportsmed Ltd | Health & social care | 2012 |
| Spudz Story Ltd | Hospitality | 2025 |
| Squires Property Services Ltd | Real estate | 2023 |
| SR Property Ltd | Real estate | 2021 |
| SRI Haraye Infotech Limited | Information & communication | 2019 |
| SRL Rail Limited | Construction | 2013 |
| SSA Holding Ltd | Professional & scientific | 2016 |
| SSB PVT Limited | Real estate | 2023 |
| SSP Developments Limited | Construction | 1997 |
| Stagnum Ltd | Hospitality | 2025 |