| BUD and Lawn Gardencare Ltd | Administrative & support | 2017 |
| Buff of Cowes Ltd | Wholesale & retail | 2013 |
| Burns Blade Repair Services Ltd | Manufacturing | 2023 |
| Bymrsm Ltd | Wholesale & retail | 2023 |
| C.V.M. (IW) Limited | Professional & scientific | 2022 |
| Cabinets by Oliver Limited | Manufacturing | 2022 |
| Calm and Chaos Ltd | Other services | 2024 |
| Cameron Oliver Limited | Financial services | 2010 |
| Cargo Ship Voyages Limited | Administrative & support | 2008 |
| Carisbrooke Shipping 295 Limited | Transport & logistics | 2025 |
| Carisbrooke Shipping 637 Limited | Transport & logistics | 2005 |
| Carisbrooke Shipping Holdings Limited | Transport & logistics | 1999 |
| Carisbrooke Shipping Limited | Transport & logistics | 1969 |
| Catercycle Ltd | Wholesale & retail | 2021 |
| Centre for Attention CIC | Education | 2019 |
| Ceramic Crafts Limited | Manufacturing | 2004 |
| CF Marine Electrical Limited | Construction | 2025 |
| CG Rentals (IOW) Limited | Households | 2021 |
| CH Wind Ltd | Manufacturing | 2026 |
| Chalet Villaret Limited | Administrative & support | 1998 |
| Charbrooke Motors Ltd | Wholesale & retail | 2024 |
| Cherry Trees I.W. Limited | Health & social care | 2010 |
| Chilliwinter Isle of Wight Ltd | Manufacturing | 2019 |
| Claire Cook Coastal Ltd | Administrative & support | 2010 |
| Classic Boat Restorations Limited | Manufacturing | 2000 |
| Clevedon House Management Company Limited | Households | 2005 |
| Cliffnett Limited | Hospitality | 2018 |
| Cliftongrade Limited | Wholesale & retail | 1975 |
| Closed Loop IOW Ltd | Water & waste | 2026 |
| Clover Farm Childcare Limited | Health & social care | 2025 |
| Co-Lab Partners Ltd | Professional & scientific | 2025 |
| Cobra Spice IOW Limited | Hospitality | 2024 |
| Collier Design Services Limited | Professional & scientific | 2015 |
| Columbia Carisbrooke Maritime Services UK Limited | Transport & logistics | 2025 |
| Commodores House Ltd | Hospitality | 2024 |
| Composite Craft Limited | Manufacturing | 2003 |
| Corby Yachts Limited | Other services | 1985 |
| Cosmic Dream Ltd | Information & communication | 2022 |
| Cotton and Leaf Ltd | Wholesale & retail | 2025 |
| Cours DE Poétique Projects Ltd | Information & communication | 2024 |
| Cowes Classics Week Limited | Arts & recreation | 2018 |
| Cowes Compliance Partnership Ltd | Information & communication | 2024 |
| Cowes Property Limited | Real estate | 2021 |
| Cowes Town Waterfront Trust Limited | Real estate | 1992 |
| Cowes Victoria Mews Limited | Professional & scientific | 1995 |
| Cowes Week Limited | Administrative & support | 2007 |
| Cowes Week Regatta Limited | Arts & recreation | 2023 |
| Cowes Yacht Haven Limited | Arts & recreation | 1992 |
| Cpblades Limited | Manufacturing | 2023 |
| Crown Port Housekeeping and Concierge Ltd | Real estate | 2026 |
| Curtain Call Creative Ltd | Arts & recreation | 2020 |
| Cysive Limited | Financial services | 2026 |
| Daisymed Ltd | Health & social care | 2023 |
| Dalyan Kebabs Limited | Hospitality | 2007 |
| Dammar Homes Ltd | Construction | 2023 |
| Dammar Properties Ltd | Real estate | 2025 |
| Dammar Property Investments Ltd | Real estate | 2025 |
| Dave Bunday & Sons Building Services Ltd | Construction | 2024 |
| David Cheverton(Production)Limited | | 1969 |
| David Heritage Limited | Manufacturing | 2000 |
| Davlock Property Management Limited | Real estate | 2010 |
| DAW Solutions IW Limited | Professional & scientific | 2026 |
| Deadman C.I.C. | Administrative & support | 2023 |
| Debourne Manor Drive Management Company Limited | Households | 2026 |
| Debra Jane Codling Limited | Extraterritorial | 2023 |
| Debra Jane DA Piedade Limited | Extraterritorial | 2023 |
| Debra Jane Limited | Extraterritorial | 2023 |
| Deco Carpentry Ltd | Construction | 2021 |
| Deco Developments IOW Ltd | Construction | 2025 |
| Designer Lingerie Ltd | Wholesale & retail | 2019 |
| DGC Projects Limited | Professional & scientific | 2024 |
| DH Wind Solution Ltd | Energy | 2024 |
| Diamond Adventures Limited | Administrative & support | 2023 |
| Discovery Travel Holidays Limited | Administrative & support | 2008 |
| DJS Autos (IOW) Limited | Wholesale & retail | 2026 |
| DK Plumbing Limited | Construction | 2015 |
| DMR Engineering (I.W.) Limited | Manufacturing | 2004 |
| Doctora Leiva Limited | Health & social care | 2022 |
| Dovehealthinertia Ltd | Health & social care | 2025 |
| DVT Lettings Ltd | Real estate | 2025 |
| East African Coastal Oceanographic Initiative Limited | Professional & scientific | 2024 |
| Easter Bay Ltd | Professional & scientific | 2025 |
| EBS Scaffolding Ltd | Construction | 2024 |
| Electric Avenue Iwight Limited | Construction | 2025 |
| Electric Planet LLP | | 2006 |
| Elixir Freshly Frozen Ltd | Wholesale & retail | 2021 |
| Ellen Macarthur Foundation | Professional & scientific | 2009 |
| Ellen Macarthur Foundation Trading Limited | Other services | 2009 |
| Ellis Harper Limited | Wholesale & retail | 2018 |
| Elmstone Architectural Limited | Professional & scientific | 2014 |
| Elmstone Design LLP | | 2010 |
| EM (IOW) Limited | Other services | 2007 |
| Endless Holdings Limited | Hospitality | 1989 |
| Engdev Labs Ltd | Professional & scientific | 2026 |
| Engenius Limited | Professional & scientific | 1995 |
| Engineering Design Solutions Limited | Professional & scientific | 2024 |
| Enhanced Skills Limited | Administrative & support | 2015 |
| Eringold Recruitment Limited | Administrative & support | 2023 |
| Eurotech 92 Consultancy Services Limited | Professional & scientific | 1990 |
| Evertrust Estate Planning Ltd | Other services | 2022 |