| Complete Tiling (Hull) Ltd | Construction | 2010 |
| Completions Project Management Ltd | Professional & scientific | 2018 |
| Conflict Studios Limited | Information & communication | 2023 |
| Consortium Collaborate Ltd | Extraterritorial | 2021 |
| Consortium Connect Ltd | Extraterritorial | 2021 |
| Consortium Executive Selection Ltd | Extraterritorial | 2021 |
| Consortium Professional Recruitment Ltd | Administrative & support | 2021 |
| Consortium Recruitment Group Ltd | Professional & scientific | 2021 |
| Constellation Holdings Limited | Financial services | 2026 |
| Constructsafe Building Services Limited | Construction | 2018 |
| Consumer Installations Ltd. | Manufacturing | 2013 |
| Cook Management Limited | Real estate | 2021 |
| Coral Belle Property Limited | Real estate | 2018 |
| Cornerstone Driver Training Limited | Education | 2026 |
| Cornerstone Yorkshire Ltd | Construction | 2013 |
| Cosmesure Ltd | Professional & scientific | 2023 |
| Costello and Burge Limited | Construction | 2004 |
| Cottage Tearooms Ltd | Hospitality | 2026 |
| Cottingham & District Traders Association Limited | Administrative & support | 2004 |
| Cottingham Barber Ltd | Other services | 2025 |
| Cottingham Building Services Limited | Construction | 2019 |
| Cottingham Dental Studio Limited | Health & social care | 2022 |
| Cottingham Equestrian Limited | Agriculture & fishing | 2025 |
| Cottingham Equestrian Services Limited | Agriculture & fishing | 2022 |
| Cottingham Golden Gate Ltd | Hospitality | 2026 |
| Cottingham Hall Investments LLP | | 2019 |
| Cottingham Leisure Limited | Arts & recreation | 1993 |
| Cottingham Nails Ltd | Other services | 2025 |
| Cottingham Parks Lodges Limited | Hospitality | 2006 |
| Cottingham QS Services Limited | Professional & scientific | 2019 |
| Cottingham Tandoori 25 Limited | Hospitality | 2025 |
| Cottingham Technical Services Limited | Manufacturing | 2011 |
| Cottingham Travel Ltd | Administrative & support | 2024 |
| Court Flats Services(Cottingham)Co.Limited | Households | 1962 |
| Craig Farley Properties Ltd | Real estate | 2025 |
| Craig Jenkinson Flooring Limited | Construction | 2018 |
| Credible FD Ltd | Professional & scientific | 2018 |
| Crew Transfer Solutions Ltd | Transport & logistics | 2019 |
| Cross Keys (Cottingham) Ltd | Hospitality | 2023 |
| Cross Keys (Nafferton) Limited | Hospitality | 2003 |
| Crosslee Manor Ltd | Health & social care | 2025 |
| Croston Park Limited | Health & social care | 2018 |
| Croston PLH Limited | Health & social care | 2025 |
| Crow Ecology Ltd | Professional & scientific | 2025 |
| CS Locksmiths Ltd | Manufacturing | 2018 |
| CT Wealth Limited | Financial services | 2017 |
| Cube Commerce Limited | Wholesale & retail | 2020 |
| Cutscene Limited | Information & communication | 2019 |
| Cutting Edge Civils Limited | Construction | 2026 |
| Cyber Azure Ltd | Administrative & support | 2020 |
| D R Kemp Limited | Wholesale & retail | 2018 |
| D.B.M.G. Limited | Other services | 1976 |
| Dagger Lane Enterprises Limited | Hospitality | 2012 |
| Daisy Medical Research Limited | Health & social care | 2010 |
| Dalys PUB Limited | Hospitality | 2026 |
| Darbandikhan Limited | Hospitality | 2021 |
| Darington Limited | Professional & scientific | 2020 |
| Davinci Health Limited | Professional & scientific | 2020 |
| DB Construction Hull Ltd | Construction | 2020 |
| Dbestproperties Ltd | Households | 2025 |
| DE Synergy Services Ltd | Information & communication | 2018 |
| Dean Marine Limited | Professional & scientific | 2023 |
| Debbienwa Limited | Wholesale & retail | 2025 |
| Debell Ltd | Professional & scientific | 2024 |
| DEE OH GEE Ltd | Administrative & support | 2023 |
| Delta Realty Group Limited | Construction | 2025 |
| Denali Innovation Limited | Information & communication | 2005 |
| Dermedicare Limited | Health & social care | 2016 |
| Dhasso Ltd | Wholesale & retail | 2025 |
| Direct Aggregate Supplies Limited | Mining & quarrying | 2004 |
| Divine Property and Investments Ltd | Real estate | 2025 |
| Dizzy's Hair Salon Ltd | Other services | 2014 |
| DJB Financial Solutions Limited | Financial services | 2012 |
| DLC1782 Limited | Households | 2024 |
| DMB Security Services Ltd | Administrative & support | 2021 |
| Dominus Motors Ltd | Wholesale & retail | 2021 |
| DP Maintenance Ltd | Manufacturing | 2020 |
| DPC (Yorkshire) Limited | Construction | 2006 |
| DR Maria Kallikourdi Psychiatry Services Limited | Health & social care | 2021 |
| Drilling Logistic Services Ltd | Mining & quarrying | 2023 |
| DRM Brickwork Limited | Construction | 2015 |
| DRM Homes Group Limited | Real estate | 2019 |
| Duncan House Limited | Real estate | 2023 |
| Dunstone Administration Services Limited | Administrative & support | 2021 |
| Dunswell Park Management Limited | Households | 1988 |
| Durham Mount Limited | Health & social care | 2026 |
| E&A Building & Joinery Ltd | Construction | 2025 |
| East Riding Energy Ltd | Construction | 2010 |
| East Yorkshire Solar Ltd | Construction | 2009 |
| East Yorkshire Taekwondo Limited | Arts & recreation | 2025 |
| Eb&Eb Holdings Ltd | Real estate | 2021 |
| Eco Lofts and Extensions Limited | Construction | 2025 |
| Ecoflame GAS and Heating Hull Limited | Construction | 2020 |
| Eden Site Services Ltd | Construction | 2019 |
| Educate Medicine Limited | Education | 2010 |
| Edumundo UK Ltd | Education | 2020 |
| EGB Investments Ltd | Real estate | 2016 |
| Egerton Property Investments Limited | Real estate | 2018 |
| Eildon Contracting Ltd | Professional & scientific | 2012 |
| EK Properties Hull Ltd | Real estate | 2020 |