| Elyfit Health Testing Ltd | Health & social care | 2024 |
| Emancipate Trade Group Ltd | Financial services | 2025 |
| Emerge (NE) Limited | Wholesale & retail | 2010 |
| Emerson Joinery Limited | Manufacturing | 2012 |
| Emperor Flooring Northeast Ltd | Construction | 2013 |
| Empire BB Ltd | Other services | 2025 |
| Energy Efficient Windows Limited | Construction | 2014 |
| Energy Glaze Ltd | Construction | 2013 |
| Engineered Precision Components Limited | Manufacturing | 2022 |
| Epicurium Ltd | Wholesale & retail | 2005 |
| Equalzero Limited | Information & communication | 2025 |
| ERV Management Solutions Limited | Professional & scientific | 2022 |
| Erwin Hymer Group Holdings UK Limited | Manufacturing | 2016 |
| Erwin Hymer Group UK Ltd | Manufacturing | 1989 |
| Escaperealityretail Ltd | Wholesale & retail | 2024 |
| ESI Consett Limited | Other services | 2025 |
| Estate Landscape North East Ltd | Administrative & support | 2022 |
| Estetics (UK) Limited | Arts & recreation | 2006 |
| ETC Legal Services Limited | Professional & scientific | 2025 |
| Euphoria AP Ltd | Arts & recreation | 2024 |
| EVE Fashion Ltd | Wholesale & retail | 2024 |
| Ever Victory Ltd | Real estate | 2020 |
| Everything English Education Consultancy Limited | Education | 2013 |
| Evolve in Time Ltd | Other services | 2023 |
| Evrywhr Ltd | Financial services | 2022 |
| Facility and Sports Club Development Services Limited | Other services | 2019 |
| Fairchild Greig & Company LLP | | 2022 |
| Fairchild Greig Operations Ltd | Professional & scientific | 2022 |
| Fairchild Greig Trusts Ltd | Professional & scientific | 2022 |
| Fairview Farm Rippon Burn Limited | Agriculture & fishing | 2026 |
| Fairways Advice Ltd | Financial services | 2019 |
| Fane Limited | Administrative & support | 2005 |
| Fast Response Building Maintenance Ltd | Construction | 2024 |
| FBL Construction Limited | Construction | 2016 |
| FBL Construction Property Limited | Real estate | 2022 |
| Fellview Falcons Ltd | Agriculture & fishing | 2025 |
| Ferg Ltd | Professional & scientific | 2015 |
| Fight Fitness Guru Ltd | Manufacturing | 2017 |
| Findley Consultants Limited | Professional & scientific | 2007 |
| Fintech Aluminium Ltd | Construction | 2019 |
| Fire Suppression Installations Limited | Public administration | 2021 |
| Firefly New Media Ltd | Information & communication | 2024 |
| FIT2THE Core Training Systems Ltd | Arts & recreation | 2016 |
| Fitsox Ltd | Wholesale & retail | 2022 |
| Flawless Finish Cleaning Ltd | Administrative & support | 2025 |
| FLP Productions Ltd | Administrative & support | 2024 |
| FM Refractory Installations Limited | Construction | 2015 |
| Focus Associates Ltd | Administrative & support | 2016 |
| Foodro Limited | Wholesale & retail | 2024 |
| FOR the Trade Group Limited | Professional & scientific | 2021 |
| FOR the Trade Property Ltd | Real estate | 2022 |
| Form & Finish Ltd | Construction | 2025 |
| Formfloor Ltd | Construction | 2026 |
| Forrest Construction Ltd | Construction | 2014 |
| Forster Renewable Energy Services Limited | Professional & scientific | 2019 |
| Forsters Retail Limited | Wholesale & retail | 2026 |
| Forte LDN Ltd | Arts & recreation | 2023 |
| Fortify Electrical Services Limited | Construction | 2020 |
| Fortify Property Solutions Ltd | Real estate | 2019 |
| Fortis Homes North East Ltd | Construction | 2024 |
| FOUNDS2FINISH Ltd | Construction | 2024 |
| Four Park Town Limited | Arts & recreation | 2019 |
| Foxineer Ltd | Information & communication | 2025 |
| FTK Vehicle Transporting Limited | Transport & logistics | 2026 |
| Ftlo Food Ltd | Information & communication | 2022 |
| Fuente Groundworks Limited | Construction | 2024 |
| Fuente Studios Limited | Construction | 2024 |
| Full Circle Safety Consultancy Ltd | Professional & scientific | 2026 |
| Furniture Clinic Limited | Manufacturing | 2005 |
| Furniture to Live Limited | Hospitality | 2008 |
| Fusion for Business Limited | Administrative & support | 2019 |
| FX Productions Ltd | Construction | 2026 |
| Fyso-Uk Ltd | Professional & scientific | 2009 |
| G F Bell Haulage Limited | Transport & logistics | 2025 |
| G Todd Rigging Ltd | Construction | 2019 |
| G&D Retailers Ltd | Wholesale & retail | 2020 |
| G&T Vivid Ltd | Professional & scientific | 2021 |
| G. a. Walton & SON Ltd | Construction | 2016 |
| G. Wilson Roofing Ltd | Construction | 2023 |
| G.Daly Telecoms Ltd | Information & communication | 2017 |
| G.E Communications Limited | Information & communication | 2019 |
| G.S Fabtec Limited | Manufacturing | 2018 |
| Gaia Natural Products Limited | Manufacturing | 2025 |
| Gaia Supplements Ltd | Wholesale & retail | 2023 |
| Ganil ERM Ltd | Wholesale & retail | 2025 |
| Gaptecuk Limited | Real estate | 2016 |
| Garry James Property Services Ltd | Construction | 2025 |
| Gary Hall Building Limited | Construction | 2009 |
| GC Consultancy Services Limited | Administrative & support | 2024 |
| Geecad Limited | Information & communication | 2011 |
| GEM Telecoms Limited | Information & communication | 2020 |
| Gemini Education and Recruiting Limited | Education | 2026 |
| Generation X Energy Limited | Energy | 2012 |
| Genuine Branding Ltd | Professional & scientific | 2019 |
| Geordies Signs Ltd | Manufacturing | 2015 |
| GET Digital Training CIC | Information & communication | 2021 |
| GET Dressed for Battle Ltd | Wholesale & retail | 1998 |
| GET Phones Fixed Ltd | Wholesale & retail | 2021 |
| GET Plastered North East Ltd | Construction | 2024 |
| GET Shirtee Ltd | Wholesale & retail | 2020 |