| Ross David Design Limited | Information & communication | 2015 |
| Rprsf Holdings Ltd | Financial services | 2025 |
| Rubi's Kitchen Ltd | Hospitality | 2025 |
| Ruby Granite Ltd | Manufacturing | 2009 |
| Rushtonaiter Enterprises Limited | Other services | 2008 |
| Russell Developments North Wales Ltd | Construction | 2022 |
| Russell Developments Property Group Ltd | Construction | 2024 |
| Rydal Penrhos (Sports & Leisure) Limited | Education | 1998 |
| Rydal Penrhos Limited | Education | 1996 |
| Rygbi 7/11 CYF | Information & communication | 2021 |
| S & P Care Ltd | Health & social care | 2021 |
| S Taylor Flooring Limited | Construction | 2022 |
| S2B Refurb Limited | Construction | 2026 |
| S4YC - Hooton Childcare Ltd | Health & social care | 2020 |
| S4YC Holding Group Limited | Financial services | 2026 |
| S4YC Limited | Arts & recreation | 2010 |
| S4YC Management Ltd | Financial services | 2026 |
| S4YC Property Ltd | Real estate | 2020 |
| SA Williams Ltd | Information & communication | 2025 |
| SAB Mohd Limited | Health & social care | 2015 |
| Sabor Food Group Ltd | Hospitality | 2026 |
| Safety Focus Limited | Professional & scientific | 2018 |
| Salofer Group Ltd | Wholesale & retail | 2023 |
| Salter Masonry Limited | Construction | 2003 |
| Samjo Enterprise Ltd | Wholesale & retail | 2018 |
| Sapphire CS Ltd | Administrative & support | 2024 |
| Sasha Handley Studio Ltd | Arts & recreation | 2023 |
| Sayers Mail Order Limited | Wholesale & retail | 1978 |
| Scarff Limited | Real estate | 2011 |
| Scholes Energy Services Ltd | Professional & scientific | 2023 |
| Scope Consultants Ltd | Information & communication | 2013 |
| Sdux Ltd | Information & communication | 2020 |
| Sea Breeze (Llandudno) Ltd | Financial services | 2026 |
| Seale Sound Solutions Limited | Information & communication | 2014 |
| Seel Plant Hire Ltd | Administrative & support | 2014 |
| Sefton Road Ltd | Real estate | 2013 |
| Selvy Ltd | Wholesale & retail | 2024 |
| Selwyn R Davies Limited | Construction | 2022 |
| Senkbeil Properties Ltd | Real estate | 2017 |
| Senkbeil Trading Ltd | Wholesale & retail | 2013 |
| Senseability Limited | Information & communication | 2023 |
| Seren Events Limited | Professional & scientific | 2019 |
| Setinstone. NW Ltd | Construction | 2018 |
| Seven Stars Healthcare Ltd | Administrative & support | 2025 |
| Shanti Moon Ltd | Health & social care | 2025 |
| Sharp Edge (Blencathra) Ltd | Professional & scientific | 2013 |
| Sheldons Cafe Bar Limited | Hospitality | 2023 |
| Sheymar Hotels (UK) Limited | Hospitality | 2012 |
| Shgc Ltd | Administrative & support | 2011 |
| Shiroi Ltd | Financial services | 2024 |
| Sian Williams Consulting Limited | Professional & scientific | 2020 |
| Signpost Shipping Ltd | Transport & logistics | 2023 |
| Simply Collective Worship Limited | Information & communication | 2016 |
| Simply Sweet Ltd | Wholesale & retail | 2024 |
| Siop Bach Limited | Wholesale & retail | 2023 |
| SIX Albert Road Limited | Real estate | 2006 |
| SK Music Limited | Arts & recreation | 2012 |
| SKW Kayaks Limited | Arts & recreation | 2022 |
| Slaters North Wales Limited | Wholesale & retail | 2000 |
| SLC Properties Cymru Limited | Real estate | 2009 |
| Smallmode Limited | Professional & scientific | 1998 |
| Smart Barber 2025 Ltd | Other services | 2025 |
| Snowdon Craft Beer Limited | Manufacturing | 2018 |
| Snowdonia Nurseries Limited | Hospitality | 2000 |
| Snowdonia Travel and Cruise Limited | Administrative & support | 2019 |
| Snowdonia Wool Ltd | Wholesale & retail | 2012 |
| Solar Fitting Ltd | Construction | 2023 |
| Sole Therapy Limited | Health & social care | 2008 |
| Soma-Shivaay Limited | Health & social care | 2026 |
| Somet Group Companies Ltd | Financial services | 2021 |
| Sonsar Ltd | Real estate | 2019 |
| Sosthenes Consultancy Ltd | Health & social care | 2019 |
| Soteria Health & Safety Consultancy Limited | Professional & scientific | 2024 |
| Soul Eventure Ltd | Professional & scientific | 2025 |
| Sound Bay Community Digital CIC | Information & communication | 2021 |
| Southpoint Investments Limited | Real estate | 2024 |
| Southstack & Bay Clothing Ltd | Wholesale & retail | 2025 |
| SP & Sons Ltd | Health & social care | 2024 |
| Spinton Property Limited | Real estate | 2023 |
| Spiral Event Services Limited | Manufacturing | 2020 |
| Spirit Lifestyle Ltd | Wholesale & retail | 2014 |
| Spitfire Competitions Ltd | Wholesale & retail | 2020 |
| Springfield Leisure Group Limited | Hospitality | 2020 |
| Springfield Property Solutions Ltd | Real estate | 2026 |
| SPS Network Ltd | Wholesale & retail | 2019 |
| Square BIT Ltd | Information & communication | 2011 |
| SRI Smilecare Ltd | Health & social care | 2021 |
| SRP Mining Limited | Mining & quarrying | 2021 |
| SS Solutions (NW) Ltd | Professional & scientific | 2021 |
| Sskk Ltd | Health & social care | 2022 |
| Stanley & Lottie Ltd | Wholesale & retail | 2020 |
| Stark Property Services Ltd | Construction | 2019 |
| Stephen Burston T/A Harrison Monarch Limited | Construction | 2022 |
| Stephen J Davis Ltd | Information & communication | 2015 |
| Sterling (Rhos on Sea) Limited | Wholesale & retail | 1985 |
| Strobe Security Solutions Limited | Administrative & support | 2007 |
| STS Electronics Ltd. | Professional & scientific | 2013 |
| Student First International Ltd | Education | 2016 |
| Studio Bond Limited | Manufacturing | 2013 |
| Sugarloaf Confectionery Ltd | Wholesale & retail | 2025 |