| Scion Solutions Ltd | Information & communication | 2003 |
| Scotia NDT Group Limited | Professional & scientific | 2015 |
| Sculptsure Ltd | Other services | 2023 |
| Secure Thinking Limited | Wholesale & retail | 2009 |
| Seed Architects Limited | Professional & scientific | 2013 |
| Sendifylife Ltd | Wholesale & retail | 2026 |
| Sensible Safety Advice Ltd | Professional & scientific | 2020 |
| Sentras 2 Ltd | Wholesale & retail | 2026 |
| Serenity Studio Hair & Beauty Ltd | Other services | 2025 |
| Servicemyboileruk Limited | Construction | 2024 |
| Sevenvectors Ltd | Information & communication | 2026 |
| Shankar Aadi Limited | Financial services | 2023 |
| Shear Metal Recycling Equipment Limited | Manufacturing | 2017 |
| Sihal Ltd | Administrative & support | 2022 |
| Simcad Design Limited | Professional & scientific | 2003 |
| Simpsons (Preston) Limited | Wholesale & retail | 2006 |
| Simpsons Motorsport Limited | Arts & recreation | 2014 |
| Sionec Ltd | Wholesale & retail | 2021 |
| Sixdof Limited | Information & communication | 2016 |
| SJA Investments Ltd | Real estate | 2015 |
| SJM Governance Ltd | Education | 2024 |
| Sjth Limited | Wholesale & retail | 2025 |
| Skin Lumino Limited | Other services | 2018 |
| Slate House Properties Ltd | Hospitality | 2005 |
| SLM Foot Care Limited | Health & social care | 2021 |
| SLM Footcare (NW) Ltd | Health & social care | 2023 |
| Smart Global Publicity Ltd | Information & communication | 2026 |
| Smart KB Ltd | Manufacturing | 2021 |
| Smash GUY 2 Limited | Hospitality | 2024 |
| Smell-Great Ltd | Real estate | 2025 |
| Smith Finishers Ltd | Construction | 2016 |
| Smith Industries Limited | Professional & scientific | 2026 |
| Smithland Electrical Limited | Construction | 2018 |
| Smyli Orthodontics Limited | Health & social care | 2012 |
| Snap 'N' Go Store Ltd | Wholesale & retail | 2025 |
| Soaps and Dreams Ltd | Manufacturing | 2020 |
| Soft Haven Upholstery Limited | Manufacturing | 2026 |
| Solace Mental Wellbeing Coaching and Training Limited | Other services | 2025 |
| Solidroute Limited | Information & communication | 1999 |
| Sound System Solutions Ltd | Manufacturing | 2018 |
| Southserve Limited | Professional & scientific | 2026 |
| Soveryapt Limited | Professional & scientific | 2014 |
| Spacesafe Ltd | Administrative & support | 2024 |
| Sparkle Beauty Training Academy Ltd | Other services | 2024 |
| Spectrum Compliance Consulting Ltd | Professional & scientific | 2025 |
| Spfn Retail Limited | Wholesale & retail | 2022 |
| Spring Meadows (Colne) Management Company Limited | Real estate | 2018 |
| Spud Leisure Ltd | Hospitality | 2015 |
| Square Connection Ltd | Education | 2012 |
| SRC Colne Ltd | Construction | 2018 |
| Ss-Scientific-Diagnostics Ltd. | Health & social care | 2026 |
| ST. Therese Academy Ltd | Education | 2021 |
| Stafco Holdings Limited | Financial services | 1981 |
| Stafco Ltd | Wholesale & retail | 2002 |
| Stafco Products Limited | Other services | 2026 |
| Station Barbers PVT Ltd | Other services | 2025 |
| Steele Smith LLP | | 2011 |
| Sterling Facilities Group Ltd | Administrative & support | 2026 |
| Stonetrough Hotel Ltd | Hospitality | 2025 |
| Storey Electrical Services Ltd | Construction | 2023 |
| Storm Hand Car Wash Ltd | Other services | 2022 |
| Stortec Construction. Ltd | Extraterritorial | 2024 |
| Streetclobber Limited | Manufacturing | 2026 |
| Struere Ltd | Real estate | 2017 |
| Stuart Mulholland Projects Ltd | Construction | 2022 |
| Stubbs Haulage Limited | Transport & logistics | 2002 |
| Sturgess Trading Ltd | Wholesale & retail | 2019 |
| Stypro Ltd | Information & communication | 2014 |
| Suites 2 U Limited | Manufacturing | 2007 |
| Super Grip (Lifting Equipment) Fabrications Limited | Manufacturing | 2000 |
| Superb Airport Executive Travel Service Limited | Transport & logistics | 2025 |
| Superclamp (Lifting Equipment) Limited | Manufacturing | 2000 |
| Supersub Colne Ltd | Hospitality | 2022 |
| Supreme Autos (NW) Ltd | Wholesale & retail | 2019 |
| Sure Design Limited | Professional & scientific | 2016 |
| Svl.Telehandler Operations Limited | Construction | 2016 |
| Sweet Dreams Sleep Consultancy Limited | Health & social care | 2024 |
| Sweetmores Anocrome Limited | Other services | 1934 |
| SWM Management Solutions Limited | Professional & scientific | 2015 |
| SWT Digital Ltd | Information & communication | 2018 |
| SYK Interiors Limited | Wholesale & retail | 2020 |
| Syldège Media Ltd | Wholesale & retail | 2026 |
| Synaptic Solutions Ltd | Professional & scientific | 2018 |
| Synergetic Digital Limited | Information & communication | 2022 |
| T & R Holdings (North West) Limited | Extraterritorial | 2010 |
| T & R Precision Engineering Limited | Administrative & support | 2003 |
| TAG Investment Enterprises Limited | Financial services | 2021 |
| Takeheat Limited | Manufacturing | 2026 |
| Takeheatuk Limited | Manufacturing | 2026 |
| Tarmate Limited | Financial services | 2011 |
| Taylors of Colne Ltd | Wholesale & retail | 2011 |
| TE Rentals NW Ltd | Real estate | 2025 |
| Teas to Please Ltd | Hospitality | 2022 |
| Teddybygraves Ltd | Transport & logistics | 2025 |
| Tees Motors Limited | Wholesale & retail | 2025 |
| Tejk Groundworks Limited | Construction | 2022 |
| Terra Contracts Ltd | Administrative & support | 2019 |
| TFG Cleaning Ltd | Real estate | 2018 |
| Thatch Living Limited | Wholesale & retail | 2017 |
| THE Aesthetic Rooms Colne Ltd | Health & social care | 2026 |