| R & H Leisure Limited | Manufacturing | 1997 |
| R a & J Faulder Ltd | Construction | 2003 |
| R D Morgan Ltd | Health & social care | 2023 |
| R G Johnston Limited | Agriculture & fishing | 2005 |
| R Stamper Plumbing & Heating Limited | Construction | 2018 |
| R.A.F General Engineering Ltd | Professional & scientific | 2017 |
| R.A.F Nuclear Engineering Ltd | Professional & scientific | 2018 |
| Rafnav Ltd | Construction | 2023 |
| Raine Support Services Limited | Professional & scientific | 2026 |
| Ramsay Brow Management Company Limited(The) | Households | 1979 |
| Rannerlow Limited | Real estate | 1992 |
| RAS Consulting (Cumbria) Ltd | Administrative & support | 2013 |
| Rayson Restoration (UK) Limited | Other services | 2003 |
| Raysons Wood Floor Sanding & Restoration Ltd | Construction | 2025 |
| RCJ Properties Cumbria Limited | Real estate | 2022 |
| RDB Fishing Ltd | Agriculture & fishing | 2024 |
| Realfood Chefs Limited | Hospitality | 2019 |
| Recreate Make CIC | Education | 2021 |
| Reeb Property Limited | Real estate | 2025 |
| Remlab Ltd. | Professional & scientific | 2014 |
| Renlim 10 Limited | Other services | 2003 |
| REP Wellness Ltd | Arts & recreation | 2025 |
| Responsive (Southampton) Ltd | Professional & scientific | 2021 |
| Retro Protect Ltd | Manufacturing | 2020 |
| Rezwana Robson Ltd | Other services | 2007 |
| RH Coaching (the Lake District) Limited | Administrative & support | 2025 |
| Rhea Holdings Limited | Financial services | 2025 |
| Riga Comm Limited | Professional & scientific | 2024 |
| Riga LET Limited | Financial services | 2025 |
| Risp Limited | Hospitality | 2019 |
| Rjmc Civils Ltd | Professional & scientific | 2020 |
| RM Mechanical Limited | Professional & scientific | 2024 |
| Rmta Services Limited | Professional & scientific | 2014 |
| Rockwealth Lake District Ltd | Financial services | 2025 |
| ROD Welford Ltd | Financial services | 2023 |
| Roewood Construction Limited | Construction | 2013 |
| ROLLS69 New Limited | Wholesale & retail | 2025 |
| Romac Whitehaven Limited | Manufacturing | 2018 |
| Roses Estate Agents Ltd | Real estate | 2022 |
| Rowans Consultancy Limited | Other services | 2013 |
| Rowbeck Strategic Support Limited | Administrative & support | 2026 |
| Rtbt Accountancy Limited | Professional & scientific | 2025 |
| RTE Electrical Engineers Limited | Manufacturing | 1998 |
| Rubicon Project Consultancy Ltd | Professional & scientific | 2012 |
| Ruskin (Cumbria) Ltd | Administrative & support | 2023 |
| Ryan and Finley Limited | Hospitality | 2014 |
| S Hughes (Keswick) Limited | Construction | 2004 |
| S I Engineering Solutions Limited | Professional & scientific | 2022 |
| S M Cumbria Limited | Professional & scientific | 2018 |
| S P Martin Electricals Limited | Construction | 2011 |
| S&N Cleeland Ltd | Manufacturing | 2025 |
| S. Hudson Services Ltd. | Transport & logistics | 2020 |
| Safelec Engineering Ltd | Professional & scientific | 2015 |
| Safsec Limited | Professional & scientific | 2018 |
| Salmo Trading Ltd | Wholesale & retail | 2026 |
| Salon 5 Hairdressing Ltd | Other services | 2012 |
| Samantha Burns Limited | Other services | 2010 |
| Sametimetomorrow Limited | Professional & scientific | 2015 |
| Samtim Limited | Health & social care | 2022 |
| Sanderson Design Services Limited | Administrative & support | 2008 |
| Sapphira Eponime Limited | Other services | 2025 |
| Sara Properties Cumbria Ltd | Real estate | 2022 |
| Sarcall Ltd. | Information & communication | 2013 |
| Saxon Building Services Limited | Construction | 2018 |
| Scalebeck Court Limited | Real estate | 1989 |
| Scantran Limited | Professional & scientific | 1999 |
| School Business Matters Limited | Education | 2018 |
| Scient Systems Ltd | Professional & scientific | 2023 |
| Scientific Arts Limited | Information & communication | 2010 |
| Sculpt Aesthetics by Rebecca Limited | Other services | 2021 |
| SDG Changemakers Ltd | Professional & scientific | 2021 |
| Seamill Ltd | Professional & scientific | 2024 |
| Seascale Golf Club Limited | Arts & recreation | 2016 |
| Sellfish Limited | Other services | 2016 |
| Servicegain Limited | Arts & recreation | 1998 |
| Seth's Bar (Cockermouth) Limited | Hospitality | 2017 |
| SGC (Cumbria) Trading Limited | Arts & recreation | 2016 |
| Shareplant Limited | Administrative & support | 2016 |
| Shavian Medical Services Limited | Health & social care | 2013 |
| Sheil Consulting Limited | Professional & scientific | 2010 |
| Shills of Cockermouth Ltd | Wholesale & retail | 2013 |
| Sikama Engineering Solutions Limited | Professional & scientific | 2012 |
| Skelly Properties Limited | Real estate | 2026 |
| Slainte Homes Limited | Extraterritorial | 2006 |
| Slangtee Ltd | Wholesale & retail | 2025 |
| Slatefell 69 Limited | Extraterritorial | 2013 |
| Slatefell Stores Limited | Wholesale & retail | 2007 |
| Sleep on IT Limited | Extraterritorial | 2003 |
| Sliding Sash Solutions Limited | Other services | 2004 |
| SM Precision Surveying Limited | Professional & scientific | 2025 |
| Smartserve AI Ltd | Information & communication | 2025 |
| Solve IT With Data Ltd | Information & communication | 2022 |
| Solway Catering Ltd | Hospitality | 2025 |
| Solway Entertainment Limited | Other services | 2016 |
| Soma Sana Ltd | Health & social care | 2024 |
| Songbird Bridal Limited | Wholesale & retail | 2015 |
| Sourcewave Media Ltd | Wholesale & retail | 2025 |
| Sovereign Project Solutions Limited | Professional & scientific | 2020 |
| Spencer Ivison Decorators Limited | Construction | 2008 |
| Spool Photo Ltd | Information & communication | 2025 |