| Darren Gardiner Limited | Construction | 2019 |
| Data Potentials Ltd | Information & communication | 2022 |
| Dave Perkins Studio Ltd | Information & communication | 2024 |
| Dave Wells Health Ltd | Health & social care | 2022 |
| David Edwards and Associates LLP | | 2002 |
| David Lawrence Property Limited | Real estate | 2017 |
| Davies Print & Embroidery Limited | Manufacturing | 2026 |
| Davies-Cousins Compliance Ltd | Financial services | 2024 |
| Daymer Consulting Ltd | Financial services | 2023 |
| Dbphysiobristol Ltd | Health & social care | 2018 |
| Dean Hospitality Limited | Hospitality | 2023 |
| Dear Stranger CIC | Other services | 2025 |
| Debunked Productions Ltd | Information & communication | 2022 |
| Dectech Renovations Ltd | Construction | 2026 |
| Delegated Services C.I.C. | Professional & scientific | 2012 |
| Delta Square Investments Limited | Real estate | 2026 |
| Dennis Gardiner & Co Ltd | Construction | 2008 |
| Dents R US Ltd | Wholesale & retail | 2019 |
| Desolate Sound System Limited | Administrative & support | 2025 |
| Developments in Software Limited | Information & communication | 2016 |
| DGT Property Investment Limited | Real estate | 2023 |
| DH Coupland & Sons Limited | Transport & logistics | 2015 |
| Dial Marketing Leisure Ltd | Arts & recreation | 2012 |
| Diamond Grounds Limited | Administrative & support | 2023 |
| Diggin Gardens Limited | Administrative & support | 2025 |
| Digital Arts Limited | Information & communication | 2005 |
| Digital Rebels Worldwide Limited | Other services | 2017 |
| Dilated Events Ltd | Hospitality | 2025 |
| Disati Ltd | Hospitality | 2024 |
| DIY Electrical Limited | Wholesale & retail | 2017 |
| DJC Pure Investments Limited | Real estate | 2018 |
| DJJ Design Consultancy Ltd | Professional & scientific | 2024 |
| DOC Film LAB Ltd | Education | 2024 |
| Docyard Ltd | Information & communication | 2025 |
| Dolphin Lifts (Western) Ltd | Manufacturing | 2003 |
| Domus Elite Ltd | Real estate | 2020 |
| Dorset & Wessex (Highbridge) Management Company Limited | Households | 2012 |
| Douglas Management Consultants Limited | Professional & scientific | 2005 |
| Doulton Investments (Bristol) Limited | Construction | 2016 |
| Downs View Court Bristol Management Company Limited | Households | 1979 |
| Doypi Ltd | Information & communication | 2025 |
| Dream Vehicle Giveaways Ltd | Wholesale & retail | 2018 |
| Driftwood Mobile Sauna Limited | Health & social care | 2021 |
| Dtis Technology Ltd | Professional & scientific | 2025 |
| Dukes Lodge (F.M.) Limited | Arts & recreation | 1964 |
| Dukes Lodge Enterprises Limited | Information & communication | 1956 |
| Durleigh Electrical Ltd | Construction | 2014 |
| Dustbusters North Somerset Ltd | Administrative & support | 2018 |
| Duval Contractors Ltd | Construction | 2011 |
| Dynamic Fire and Security Solutions Ltd | Administrative & support | 2017 |
| E J Rowley Ltd | Real estate | 2021 |
| E&L Services Ltd | Hospitality | 2025 |
| E-Medicals Group Ltd | Administrative & support | 2019 |
| E-Medicals Ltd | Administrative & support | 2019 |
| E-Medicals UK Ltd | Administrative & support | 2004 |
| Eastern European Enterprise Ltd | Financial services | 2025 |
| Easton Haines Limited | Administrative & support | 2017 |
| Eazy Peasey Cleaning Ltd | Construction | 2021 |
| EB Plumbing Ltd | Construction | 2026 |
| Ebsd Consultants Limited | Information & communication | 2010 |
| Eclipse Catering Equipment Hire Ltd | Administrative & support | 2007 |
| Eco Green Partners Ltd | Construction | 2012 |
| Eco Materials Limited | Construction | 2019 |
| Ecohub Technologies Limited | Information & communication | 2023 |
| Edward Andrews Ltd | Real estate | 2020 |
| Edward Sutherland Advisory Services Ltd | Professional & scientific | 2021 |
| Edwards Property Lettings (Bristol) LLP | | 2025 |
| Eerie Emporium Ltd | Wholesale & retail | 2023 |
| EIS Services Limited | Construction | 2001 |
| Eisey's Gym Limited | Arts & recreation | 2021 |
| Ekota Clevedon Ltd | Hospitality | 2024 |
| ELB 1 Limited | Extraterritorial | 2016 |
| Elite Services (SW) Ltd | Transport & logistics | 2018 |
| Ellie Wright Ltd | Arts & recreation | 2010 |
| ELM Croft Joinery Limited | Construction | 2021 |
| Elmsoftware Ltd | Information & communication | 2021 |
| Elserv Limited | Construction | 2020 |
| Elton Road Clevedon Flat Management Company Limited | Households | 1979 |
| ELY Acquisition Limited | Professional & scientific | 2016 |
| Elysian Training Ltd | Professional & scientific | 2006 |
| Embrace Investments Ltd | Other services | 2022 |
| Emily Hayward Limited | Other services | 2015 |
| Emperor Housing Limited | Real estate | 2024 |
| Empyr Agency Ltd | Information & communication | 2026 |
| Emsworth House Management Company Limited | Real estate | 2019 |
| Energized Electrics Limited | Energy | 2010 |
| Enigma Research and Development Limited | Professional & scientific | 2013 |
| Entersafe Limited | Real estate | 1987 |
| Envira-Mech Services Holdings Limited | Construction | 2021 |
| Envira-Mech Services Limited | Construction | 2008 |
| Environmental Policy and Regulation Limited | Professional & scientific | 2016 |
| Eposit Solutions Limited | Information & communication | 2009 |
| Epps Limited | Information & communication | 1996 |
| Escala Tapas Ltd | Hospitality | 2022 |
| Estuary Marine Ltd | Manufacturing | 2019 |
| Euphoric Gifts Limited | Wholesale & retail | 2021 |
| Eureka Cook Store Ltd | Wholesale & retail | 2024 |
| Eventware Services Limited | Administrative & support | 2021 |
| Everbulk Ltd | Wholesale & retail | 2025 |
| Evergrain Limited | Administrative & support | 2025 |