| Sense Earth Limited | Administrative & support | 2012 |
| Seven (Holdco) Limited | Financial services | 2025 |
| Severn House (Queens Road Clevedon) Management Company Limited | Hospitality | 1985 |
| Severn Lawn Legal Limited | Professional & scientific | 2023 |
| Severnside Fabrications Limited | Wholesale & retail | 1990 |
| SGM Engineering Limited | Construction | 2009 |
| Shannon Plant Sales & Hire Limited | Administrative & support | 1996 |
| Sharkegg Limited | Information & communication | 2012 |
| Shaws PUB Company Ltd | Hospitality | 2023 |
| Shelfmore Services Limited | Real estate | 1994 |
| Sherburn House Management Company Limited | Real estate | 2001 |
| Shergold Conservatories Limited | Construction | 2016 |
| Shergold Landscaping Ltd | Administrative & support | 2018 |
| Shipway Developments Ltd | Construction | 2018 |
| Shout About Agency Ltd | Professional & scientific | 2024 |
| Shprice Ltd | Professional & scientific | 2025 |
| Sierrafoxtrot Ltd. | Professional & scientific | 2012 |
| Sifi Limited | Professional & scientific | 2012 |
| Signet Signs Limited | Manufacturing | 1978 |
| Silloth Storage Company Limited | Wholesale & retail | 2000 |
| Silvergates Consultancy Limited | Professional & scientific | 2011 |
| Simmo Property Ltd | Real estate | 2020 |
| Simmons Tree Care Limited | Administrative & support | 2019 |
| Simon W Davies Media Ltd | Information & communication | 2014 |
| Simplified Support Ltd | Education | 2025 |
| Simply Environmental Limited | Extraterritorial | 2007 |
| Simply Surf BUS Limited | Wholesale & retail | 2018 |
| Simsco Ltd | Financial services | 2022 |
| SIX Bricks Investments Ltd | Real estate | 2025 |
| SIXTY8 at the Marina RTM Company Limited | Households | 2015 |
| Skreen Holdings Limited | Real estate | 2016 |
| SLH Marketing Limited | Administrative & support | 2017 |
| SLS Construction Limited | Construction | 2004 |
| SM4RT Labs Ltd | Information & communication | 2025 |
| Smith Consult Limited | Professional & scientific | 2012 |
| SMW Solutions Limited | Wholesale & retail | 2025 |
| SO Gorgeous Bridal Ltd | Wholesale & retail | 2026 |
| Soap Suds (Bristol) Laundry Service Ltd | Administrative & support | 2015 |
| Soil Check Ltd | Professional & scientific | 2021 |
| Solar Clean (SW) Limited | Administrative & support | 2023 |
| Solarsense (UK) Ltd | Construction | 2000 |
| Solarsense (UK) Property Limited | Financial services | 2011 |
| Solarsense Employee Ownership Trust Limited | Financial services | 2022 |
| Solder-On Ltd | Information & communication | 2019 |
| Solver Ltd | Professional & scientific | 2012 |
| Somerset Braking Systems Ltd | Manufacturing | 2018 |
| Somerset Chase (WSM) Management Company Limited | Households | 2003 |
| Sondiz Ltd | Information & communication | 2018 |
| Sound Check Ltd | Arts & recreation | 2024 |
| Soundfulness Ltd | Health & social care | 2024 |
| South West Cottages Limited | Real estate | 2022 |
| South West Surgery Limited | Health & social care | 2017 |
| Southcote Commercials Limited | Extraterritorial | 2012 |
| Southern Lights Limited | Information & communication | 2009 |
| Southfield Court Management Co Limited | Households | 1971 |
| Southwell Court RTM Company Limited | Households | 2022 |
| Southwell Heritage Trust | Arts & recreation | 2010 |
| Sparkle Restore Ltd | Administrative & support | 2015 |
| Spartan Electrical Solutions Ltd | Construction | 2014 |
| SPD Training and Consultancy Ltd | Education | 2019 |
| Spilsbury's of Clevedon (Outfitters) Limited | Real estate | 1976 |
| Spinning Weal Limited | Wholesale & retail | 2007 |
| SPJ Limited | Wholesale & retail | 2001 |
| Springfield House Management Company Limited | Households | 1991 |
| Square PEG Contracting Ltd | Construction | 2025 |
| SSB Ltd | Extraterritorial | 2023 |
| ST Abbeville (Freehold) Company Limited | Real estate | 2006 |
| ST Aidans Close (Bristol) Management Company Limited | Households | 1986 |
| ST Christophers Court Management Co.Limited | Households | 1972 |
| ST Georges Park (WSM) Management Company Limited | Households | 2002 |
| ST Johns Park (Bristol) Management Company Limited | Households | 2003 |
| ST. John's Court Axbridge Management Company Limited | Households | 1984 |
| ST. Katherines Management Company Limited | Households | 1984 |
| Stacey Architects Ltd | Professional & scientific | 2021 |
| Stacey Financial Planning Limited | Financial services | 2012 |
| Stacey Property Lettings LLP | | 2021 |
| Stackd Technologies Ltd. Ltd | Information & communication | 2026 |
| Stackpool Ltd | Information & communication | 2020 |
| Staddons Block Limited | Households | 2024 |
| Star Hill Management (NO.2) Limited | Households | 2000 |
| Star Hill Management Limited | Households | 2000 |
| Startthat Limited | Information & communication | 2013 |
| Stationery & Craft Select Ltd | Wholesale & retail | 2011 |
| Stationery House (SW) Limited | Wholesale & retail | 2021 |
| STC Barbers Ltd | Other services | 2020 |
| STC Clevedon Limited | Hospitality | 2016 |
| Steel Walkway Supplies Ltd | Wholesale & retail | 2014 |
| Steve HOY Building Services Ltd | Construction | 2017 |
| Steve Humphrey Electrical Limited | Construction | 2020 |
| Steven Smith Town & Country Estate Agents Ltd | Real estate | 2010 |
| Stewart Investment Planning Limited | Financial services | 2003 |
| Stone Clarkson Limited | Real estate | 2019 |
| Story House Collective Limited | Information & communication | 2020 |
| Storyland Ltd | Information & communication | 2015 |
| Strawberry Development SW Ltd | Construction | 2025 |
| Studio Stiles Limited | Professional & scientific | 2019 |
| Sulis Mews (Gloucester) Management Company Limited | Households | 2002 |
| Sullys Trading Ltd | Professional & scientific | 2023 |
| Summer Court (Locking Castle) Management Company Limited | Households | 1999 |
| Summerell Properties Ltd | Real estate | 2025 |