| SJU Outdoor Spaces Limited | Administrative & support | 2018 |
| Skills Gain Limited | Education | 2023 |
| Skipton Town & Country Properties Ltd | Real estate | 2024 |
| Sknn Sanctuary Skincare Ltd | Other services | 2026 |
| Skylight Forestry Ltd | Construction | 2018 |
| Sleeks Clothing Ltd | Wholesale & retail | 2024 |
| Sleep Time Beds Ltd | Wholesale & retail | 2018 |
| SLL Group Ltd | Real estate | 2023 |
| SM Cater Ltd | Hospitality | 2026 |
| Smardt Chillers (UK) Limited | Manufacturing | 2018 |
| Smarterwaste Limited | Water & waste | 2017 |
| Smartwatch Solutions Limited | Information & communication | 2009 |
| SMB Distribution Limited | Transport & logistics | 2010 |
| Smile Office Supplies North Limited | Wholesale & retail | 2009 |
| Smith and SON Heavy Equipment Engineers Limited | Administrative & support | 2017 |
| Smittechsolutions Ltd | Information & communication | 2022 |
| Smokers Korner Limited | Wholesale & retail | 2021 |
| Snacko's Shack | Education | 2024 |
| Snagging Inspections Limited | Real estate | 2002 |
| Snap Web Solutions Ltd | Information & communication | 2025 |
| Snug Sleep Ltd | Wholesale & retail | 2024 |
| Soft Options (Holdings) Ltd | Financial services | 2018 |
| Soft Options (Systems) Ltd | Information & communication | 2012 |
| Soft Start Tech Limited | Construction | 2009 |
| Sonic Direct Ltd | Extraterritorial | 2012 |
| Sonos Furniture Ltd | Wholesale & retail | 2021 |
| Sontex (Machinery) Limited | Manufacturing | 1961 |
| Sood Investments (Leeds) Limited | Real estate | 2011 |
| Sorella Hair Specialists Ltd | Other services | 2025 |
| Spacemouse Limited | Administrative & support | 1999 |
| Spark Merchandise Ltd | Other services | 2020 |
| Speckled EGG Business Solutions Ltd | Professional & scientific | 2018 |
| Spell Book and Candle Gifts Ltd | Wholesale & retail | 2025 |
| Spen Bearings Limited | Administrative & support | 2017 |
| Spen Design Limited | Construction | 2017 |
| Spen TAP Ltd | Hospitality | 2022 |
| Spen Valley CNC Services Limited | Professional & scientific | 2017 |
| Spen Valley Ironworks Limited | Manufacturing | 2015 |
| Spen Valley Joiners Limited | Construction | 2017 |
| Spenbank Holdings Limited | Real estate | 1956 |
| Spenborough Forget ME NOT Fund | Other services | 2004 |
| Spenborough Model & Experimental Engineers Limited | Administrative & support | 2004 |
| Spenborough Properties Ltd | Real estate | 2011 |
| Spencer & Sandy Estates Limited | Real estate | 2022 |
| SPM Joinery Limited | Construction | 2022 |
| Sprayrend UK Limited | Construction | 2014 |
| Springfield Cleaning Services Limited | Other services | 2010 |
| Springwood Music Ltd | Information & communication | 2024 |
| Sprint Couriers and Light Haulage Limited | Transport & logistics | 2022 |
| SPS Leeds Ltd | Construction | 2021 |
| Squirrel Place Limited | Households | 2026 |
| SR Logistics Limited | Transport & logistics | 2026 |
| SR Realisations Limited | Manufacturing | 2003 |
| SR Water Services Ltd | Extraterritorial | 2023 |
| Ssculpt Collective Ltd | Professional & scientific | 2025 |
| SSL Autoparts Limited | Wholesale & retail | 2013 |
| SSL Holdings (Yorkshire) Limited | Financial services | 2025 |
| ST Elmo's Ltd | Hospitality | 2025 |
| Stabilità Studio Limited | Professional & scientific | 2025 |
| Stansfield Arms West Yorkshire Ltd | Hospitality | 2018 |
| Stanza Clean Ltd | Administrative & support | 2019 |
| Stat Electrical Services Ltd | Construction | 2017 |
| Stat M&E Services Ltd | Construction | 2022 |
| Staveley Garages Limited | Real estate | 1933 |
| Stealth Trading Ltd | Professional & scientific | 2009 |
| Steelfinder Services Limited | Wholesale & retail | 2018 |
| Steeton Hall Hotel Limited | Hospitality | 2014 |
| Steplo LLP | | 2016 |
| Steve Winks Memorials Ltd | Other services | 2012 |
| Stirring Silver Limited | Manufacturing | 2022 |
| STJ Asset Management Limited | Real estate | 2014 |
| Stone Developments (Land & Commercial) Limited | Construction | 2023 |
| Stone Developments (PS) Limited | Construction | 2019 |
| Stone Developments (Yorkshire) Limited | Construction | 2016 |
| Stonedale Construction Limited | Construction | 2016 |
| Stonedale Group Holdings Ltd | Financial services | 2023 |
| Stonedale Investments Limited | Construction | 2023 |
| Stonegate Storage Ltd | Transport & logistics | 2025 |
| Stop-Inn-Time Ltd | Hospitality | 2020 |
| Storeys of Travel Limited | Administrative & support | 2026 |
| Straight Life Limited | Real estate | 2009 |
| Strand HR Coaching & Consultancy Limited | Professional & scientific | 2018 |
| Stratum 100 Limited | Administrative & support | 2014 |
| Stripes Recruitment Ltd | Administrative & support | 2024 |
| Strive Holdings WY Ltd | Real estate | 2024 |
| Structural Manufactured Products Limited | Manufacturing | 2007 |
| Stump Cross Halifax Limited | Hospitality | 2023 |
| Sturdys Farm Caravan and Camping Park Limited | Administrative & support | 2020 |
| Sublime Energy Services Limited | Construction | 2018 |
| Success Logistics Solutions Limited | Transport & logistics | 2013 |
| Sugar Events Limited | Hospitality | 2021 |
| Summit Health Solutions Limited | Wholesale & retail | 2025 |
| Sunnah Search Ltd | Professional & scientific | 2025 |
| Supapak Limited | Administrative & support | 1980 |
| Supercede Ltd | Construction | 2019 |
| Supreme Drainage & Plumbing Ltd | Water & waste | 2019 |
| Surgical LED Aesthetics Ltd | Other services | 2025 |
| Sussex Promotions Limited | Wholesale & retail | 2003 |
| Sustainable Symphony Limited | Wholesale & retail | 2023 |
| Swift (Relief Driving Services) Ltd | Transport & logistics | 2025 |