| Your Heart Health Screening Limited | Health & social care | 2021 |
| Your Place Home From Home Ltd | Hospitality | 2017 |
| Your Storage Partner Limited | Real estate | 2024 |
| Yourfutureisnow Ltd | Transport & logistics | 2019 |
| YSA Delivery Limited | Transport & logistics | 2023 |
| YT1 Hospitality Limited | Real estate | 2025 |
| Yuayfa Ltd | Hospitality | 2021 |
| Yume World Group Ltd | Arts & recreation | 2021 |
| Yume World Services Limited | Professional & scientific | 2022 |
| Yummy Fleet Ltd | Transport & logistics | 2025 |
| Yvette's Secret Wardrobe Ltd | Wholesale & retail | 2018 |
| Z Creative Group Ltd | Arts & recreation | 2018 |
| Zahra (NW) Ltd | Wholesale & retail | 2016 |
| Zalvento Creations Ltd | Administrative & support | 2025 |
| ZAM Care Group Ltd | Health & social care | 2025 |
| Zandy Ltd | Real estate | 2025 |
| ZAS Estates Limited | Real estate | 2026 |
| Zayan Tandoori Ltd | Administrative & support | 2018 |
| Zenith Auctions Ltd | Administrative & support | 2025 |
| Zenith Holdings (Manchester) Limited | Professional & scientific | 2025 |
| Zensa Limited | Information & communication | 2015 |
| Zeroith Asset Management Ltd | Real estate | 2022 |
| Zest BC Limited | Professional & scientific | 2024 |
| Zeynepgul Ltd | Hospitality | 2021 |
| ZHU ZHU Ltd | Wholesale & retail | 2011 |
| Zie’S Properties Limited | Real estate | 2023 |
| ZKR Ltd | Administrative & support | 2021 |
| ZL Energy Ltd | Real estate | 2016 |
| Zlotnik Estates Limited | Real estate | 2025 |
| ZM Medico Ltd | Health & social care | 2021 |
| ZMK (NW) Limited | Wholesale & retail | 2013 |
| Zoco Limited | Wholesale & retail | 2021 |
| ZOE Eccles Accountancy Ltd | Professional & scientific | 2020 |
| ZOE KAY Jewellery Limited | Wholesale & retail | 2013 |
| ZOE of Church Road Limited | Health & social care | 2011 |
| Zotehomes Ltd | Other services | 2018 |
| ZR Consultancy Ltd | Construction | 2025 |
| ZS Children's Services Ltd | Health & social care | 2010 |
| ZTK Medical Limited | Health & social care | 2019 |
| Zulu Technology Ltd | Information & communication | 2024 |
| ZW Construction Limited | Construction | 2013 |
| ÖL Brewery Limited | Hospitality | 2017 |