| ENA Property Services Ltd | Construction | 2016 |
| Endeavour Learning Trust | Education | 2011 |
| Endeavour Photography Limited | Professional & scientific | 2014 |
| Ener(Gy) Ambit Ltd | Professional & scientific | 2019 |
| Energized Forever Ltd | Health & social care | 2025 |
| Energy Ace Global Limited | Manufacturing | 2013 |
| Energy Ace Solutions Limited | Manufacturing | 2010 |
| Energy Analytics Ltd | Energy | 2025 |
| Energy PAY Ltd | Administrative & support | 2025 |
| Energy Saving Consortium Service Company Ltd | Professional & scientific | 2015 |
| Energyace Home Limited | Manufacturing | 2014 |
| Energyace Limited | Manufacturing | 2002 |
| Enes 68 Catering Limited | Hospitality | 2017 |
| Engage Crop Solutions Ltd | Agriculture & fishing | 2012 |
| Engine Support Center Ltd | Wholesale & retail | 2020 |
| Englands Limousines Limited | Administrative & support | 2012 |
| English Rose Financial Planning Ltd | Professional & scientific | 2018 |
| English Trading Company Limited | Wholesale & retail | 2001 |
| English Trading Holdings Ltd | Administrative & support | 2011 |
| Enlist 24 Ltd | Administrative & support | 2025 |
| Enpo Limited | Professional & scientific | 2020 |
| Ensco 1466 Limited | Professional & scientific | 2022 |
| Enterprise Specialist Sealants Limited | Construction | 2006 |
| Entity-Trade Park Limited | Wholesale & retail | 2016 |
| Entrytech Security Installer Ltd | Administrative & support | 2018 |
| Entwistle Homes Limited | Real estate | 2020 |
| Envelope Labour Solutions Ltd | Administrative & support | 2023 |
| Enviroaircon Limited | Construction | 2015 |
| Enviropax Limited | Manufacturing | 2010 |
| Enviroply Developments Ltd | Real estate | 2025 |
| Enviroply Roofing Ltd | Construction | 2013 |
| Envirovox Ltd | Professional & scientific | 2020 |
| EO Gyms Ltd | Arts & recreation | 2023 |
| Eotm Limited | Wholesale & retail | 2022 |
| Epax Topco Limited | Professional & scientific | 2016 |
| Epci Services Limited | Professional & scientific | 2019 |
| Epitomy Solutions Limited | Information & communication | 2000 |
| EPO Logistics Limited | Administrative & support | 2014 |
| EPR Environmental Consultancy Limited | Professional & scientific | 2023 |
| EQL Health Limited | Information & communication | 2018 |
| EQL Limited | Information & communication | 2019 |
| Equalities and Justice National Network CIC | Information & communication | 2012 |
| EQUALS42 Ltd | Manufacturing | 2010 |
| Equilibrium Wealth Management Limited | Financial services | 1995 |
| Equity Growth Management Limited | Real estate | 2014 |
| Eqwise Limited | Education | 2012 |
| Eram Limited | Arts & recreation | 2017 |
| Erap (Consultant Ecologists) Ltd | Professional & scientific | 2016 |
| Eraworld Limited | Real estate | 1986 |
| Erfmann Manor Farm Ltd | Agriculture & fishing | 2026 |
| ERH Contracting Ltd | Construction | 2017 |
| Eric Nicholls T/A Pro-Drive Services Ltd | Transport & logistics | 2026 |
| Eroma Holdings Limited | Wholesale & retail | 2021 |
| Eros Property Limited | Real estate | 2024 |
| ERT Group Limited | Real estate | 2025 |
| ES Personal Training Ltd | Health & social care | 2014 |
| Escape Bars Ltd | Hospitality | 2021 |
| Escape Brewery Bars Limited | Hospitality | 2021 |
| Escape Chorley Ltd | Arts & recreation | 2025 |
| Escon Development Ltd | Construction | 2021 |
| ESG Global (Energy) Ltd | Information & communication | 1994 |
| Esg-Utiligroup Bidco Limited | Administrative & support | 2017 |
| Esg-Utiligroup Intermediate Limited | Administrative & support | 2017 |
| Esmee LDN Limited | Arts & recreation | 2026 |
| ESO143 Ltd | Hospitality | 2026 |
| Espectro Advisory Limited | Professional & scientific | 2021 |
| Espuma Cleaner Solutions Limited | Wholesale & retail | 2006 |
| Espuma Manufacturing Limited | Manufacturing | 2024 |
| Esqe Ltd | Health & social care | 2018 |
| Essa Acquisitions & Sales Ltd | Wholesale & retail | 2025 |
| Essential Employment Limited | Other services | 2006 |
| Essential Recycling Ltd | Water & waste | 2020 |
| Essesea Limited | Wholesale & retail | 2010 |
| Essex Fire Protection Limited | Public administration | 2016 |
| Esta N IAN Ltd | Wholesale & retail | 2025 |
| Estetica Permanent Cosmetics & Piercing Boutique Ltd | Other services | 2023 |
| ESW Property Services Ltd | Real estate | 2024 |
| Eternal Bloom Limited | Wholesale & retail | 2015 |
| Ethan EVE Transport Limited | Transport & logistics | 2023 |
| ETP Consultancy Ltd | Public administration | 2021 |
| Etta Industries Ltd | Hospitality | 2026 |
| Eunoia Consultants Limited | Professional & scientific | 2022 |
| Eureka Tuition Limited | Education | 2017 |
| Euro Aviation Services Limited | Professional & scientific | 2000 |
| Euro Motorz Limited | Other services | 2019 |
| Eurodiesel (Chorley) Limited | Wholesale & retail | 2011 |
| Euromedia Associates Limited | Information & communication | 1991 |
| European Building Supplies Ltd | Manufacturing | 2007 |
| European Salvage Limited | Water & waste | 2008 |
| European-Hose Ltd | Manufacturing | 2003 |
| Euxton Barbers Ltd | Other services | 2025 |
| Euxton Deli Ltd | Hospitality | 2020 |
| Euxton Group Ltd | Professional & scientific | 2013 |
| Euxton Property Services Limited | Wholesale & retail | 2005 |
| Euxton Software Ltd | Information & communication | 2003 |
| Euxton Tiles Limited | Construction | 2025 |
| EV Heroes Limited | Manufacturing | 2020 |
| Evans Bespoke Interiors Limited | Manufacturing | 2022 |
| Evans Medical Services Ltd | Health & social care | 2019 |
| Evaristo Property Services Limited | Real estate | 2022 |