| Ryan's Property Ltd | Real estate | 2020 |
| Rysa Properties Ltd | Real estate | 2020 |
| Rytel IT Solutions Limited | Information & communication | 2017 |
| S & D Services London Ltd | Water & waste | 2009 |
| S a J Service Ltd | Wholesale & retail | 2004 |
| S Prashar Limited | Information & communication | 2007 |
| S Renewals Assets Limited | Construction | 2025 |
| S Talukdar Ltd | Real estate | 2025 |
| S&A Asset Ltd | Real estate | 2025 |
| S&A Consultancy Management Ltd | Professional & scientific | 2022 |
| S&M Builders London Limited | Construction | 2021 |
| S&T Developments Limited | Households | 2021 |
| S.N.R. Property Co (U K) Limited | Real estate | 2005 |
| SA Joiners Limited | Construction | 2009 |
| Sachien Soft Limited | Information & communication | 2007 |
| Sadaf Healthcare Limited | Health & social care | 2026 |
| Safe Healing Centre Ltd | Health & social care | 2025 |
| Safecare Consultancy Ltd | Professional & scientific | 2013 |
| Safety Call Heating Ltd | Construction | 2022 |
| Saffire Avenue Limited | Real estate | 2021 |
| Saffire Development Ltd | Real estate | 2021 |
| Saffire Holdings Ltd | Real estate | 2022 |
| Sagar Software Solutions Limited | Information & communication | 2010 |
| Sahyan Trading Ltd | Information & communication | 2021 |
| Saigrace Pharmacy Ltd | Wholesale & retail | 2008 |
| Sailing Stones Services Ltd | Real estate | 2024 |
| Saismic Limited | Real estate | 2003 |
| SAK Property Holdings Limited | Households | 2016 |
| Saleena Bhoyroo Learning Ltd | Education | 2024 |
| Sales Partner Limited | Professional & scientific | 2004 |
| Saliba Ltd | Construction | 2019 |
| Salisbury Place (Dagenham) Management Company Limited | Households | 1989 |
| SAM & LIZ Ltd | Real estate | 2024 |
| Samnish Limited | Wholesale & retail | 2024 |
| Samsara London Limited | Construction | 2020 |
| Sanpas Limited | Health & social care | 2006 |
| Sanskriti Ltd | Arts & recreation | 2012 |
| SAP Vision Ltd | Information & communication | 2026 |
| Sapphire Care Ltd | Health & social care | 2022 |
| Sapphire Sky London Ltd | Administrative & support | 2013 |
| Sara ZAC Medicals Limited | Extraterritorial | 2009 |
| Saramco Ltd | Hospitality | 2016 |
| SAS International Trading Services Ltd | Wholesale & retail | 2025 |
| Saudi Assertion Ltd | Wholesale & retail | 2024 |
| Sauzal Ltd | Other services | 2016 |
| Savov Trans Ltd | Construction | 2018 |
| SB Reclaimed Materials Ltd | Wholesale & retail | 2023 |
| Sband Cleaning Ltd | Construction | 2024 |
| SC Great Construction Ltd | Construction | 2023 |
| Scailer Ltd | Information & communication | 2025 |
| Scholar Path Education Ltd | Education | 2026 |
| Scopus Journal Services Ltd | Information & communication | 2025 |
| Scrap Foundry Ltd | Professional & scientific | 2024 |
| Scrubnshiine Ltd | Administrative & support | 2025 |
| SDS Carpentry & Building Services Ltd | Manufacturing | 2018 |
| Sebastian Durham Holdings Ltd | Financial services | 2018 |
| Sebastian Plumbing & Heating Ltd | Construction | 2016 |
| Sebif UK Ltd | Construction | 2015 |
| Sefre Architects & Research Limited | Professional & scientific | 1998 |
| Seir Estates Ltd | Real estate | 2021 |
| Selvam LA Properties Limited | Real estate | 2025 |
| Semwaves Limited | Information & communication | 2018 |
| Sencare Recruitment Ltd | Administrative & support | 2020 |
| Sennik Ltd | Professional & scientific | 2012 |
| Sensationforthesoul Limited | Hospitality | 2024 |
| Serte Ltd | Construction | 2017 |
| SET Connect Limited | Information & communication | 2021 |
| Seymour Court Care Limited | Health & social care | 2017 |
| Shabab and Enas Investment Ltd | Real estate | 2023 |
| Shami PVT Ltd | Information & communication | 2017 |
| Shan Taxcare Ltd | Professional & scientific | 2012 |
| Shani Projects Ltd | Professional & scientific | 2025 |
| Sharan Property Assets Ltd | Real estate | 2006 |
| Sharanja Limited | Professional & scientific | 2021 |
| Sharonas Coaching Limited | Education | 2021 |
| Shaw Family Investments Limited | Real estate | 2014 |
| Shayan MUA Limited | Health & social care | 2015 |
| Sheesh Factory Ltd | Hospitality | 2022 |
| Sheesh London Ltd | Extraterritorial | 2021 |
| Sheesh Piccadilly Ltd | Hospitality | 2022 |
| Sheesh Restaurant Limited | Hospitality | 2015 |
| Sheikh Services Ltd | Health & social care | 2025 |
| Sheriff Educators Tamkeen Solutions Ltd | Education | 2023 |
| Sheriffs Holding Limited | Transport & logistics | 2021 |
| Shift Investments Ltd | Real estate | 2018 |
| Shimla Mirch Limited | Hospitality | 2024 |
| Shirland Management Ltd | Information & communication | 2007 |
| Shop Array Ltd | Wholesale & retail | 2019 |
| Shoreditch Italia Ltd | Wholesale & retail | 2025 |
| Shova Enterprise Ltd | Wholesale & retail | 2025 |
| Shps Trading Limited | Real estate | 2020 |
| Siberty 2024 Ltd | Health & social care | 2024 |
| Sienna Greys Limited | Professional & scientific | 2021 |
| Sigma Property Co. Limited | Real estate | 2012 |
| Sigma Property Developments Ltd | Construction | 2019 |
| Sigma Property New Developments Limited | Real estate | 2019 |
| Sileni's Best Firewood Ltd | Wholesale & retail | 2018 |
| Silk Route Business Limited | Wholesale & retail | 2023 |
| Silver J ELM Limited | Health & social care | 2025 |
| Silverhind Court (Freehold) Limited | Households | 2016 |