| Starling Tattoos Ltd | Other services | 2024 |
| Starphysio Ltd | Health & social care | 2025 |
| Stedham Hall Management Company Limited | Households | 1972 |
| Stedman Accounting Limited | Professional & scientific | 2020 |
| Steele Formwork Ltd. | Construction | 2020 |
| Steellink Fabrication Ltd | Construction | 2026 |
| Steer Property Development Ltd | Real estate | 2024 |
| Stembridge Limited | Construction | 2021 |
| Steph Cooper Plumbing Ltd | Construction | 2023 |
| Stephen Rines Limited | Construction | 2005 |
| Stephen Streeter Education Ltd | Education | 2017 |
| Stepping Stone Learning Solutions Ltd | Information & communication | 2014 |
| Sterling Garden Services Ltd | Construction | 2012 |
| Steve Foye Coaching and Consultancy Limited | Administrative & support | 2021 |
| Steve Lambourne Ltd | Professional & scientific | 2014 |
| Steve Marriott Licensing Co. Limited | Arts & recreation | 1989 |
| Stewart Properties Sussex Limited | Real estate | 2023 |
| Stilt House Close Ltd | Real estate | 2021 |
| Stingray OPS Limited | Professional & scientific | 2025 |
| Stirling Contracts Ltd | Professional & scientific | 2025 |
| STM Structural Engineers Ltd | Professional & scientific | 2015 |
| Stockbridge (Nottingham) Limited | Construction | 2015 |
| Stockbridge Land Limited | Professional & scientific | 2018 |
| Stockton Aviation Ltd | Transport & logistics | 2020 |
| Stoke Road Guildford Limited | Real estate | 2021 |
| Stomp Design Limited | Other services | 2005 |
| Stone & Valley Limited | Other services | 2026 |
| Stone and Skillet Ltd | Hospitality | 2022 |
| Stone Barn (Donnington) Limited | Construction | 2020 |
| Stone JAR Properties Ltd | Real estate | 2022 |
| Stonehurst Build Ltd | Construction | 2018 |
| Stonehurst Properties Ltd | Construction | 2012 |
| Store Property (Chichester) Limited | Real estate | 1996 |
| Store Property Developments Limited | Real estate | 1949 |
| Store Property Estates Limited | Real estate | 1960 |
| Store Property Holdings Limited | Professional & scientific | 1979 |
| Store Property Investments Limited | Real estate | 1955 |
| Store Property Land Limited | Real estate | 2019 |
| Store Property Limited | Real estate | 2001 |
| Storm Engineering Technologies Ltd | Professional & scientific | 2023 |
| Storm Marine Limited | Professional & scientific | 2016 |
| Storrington Convenience Store Ltd | Wholesale & retail | 2023 |
| Stowaway Bikes Ltd | Wholesale & retail | 2011 |
| Strainx UK Ltd | Professional & scientific | 2026 |
| Strand Investigations Limited | Administrative & support | 2026 |
| Strategia Games Limited | Wholesale & retail | 2018 |
| Strategic and Technical Consulting Ltd | Professional & scientific | 2009 |
| Strategic Resilient Partners Ltd | Professional & scientific | 2023 |
| Strategical Ltd | Professional & scientific | 2023 |
| Strategy and Soul Ltd | Administrative & support | 2020 |
| Stratoventure Ltd | Professional & scientific | 2024 |
| Stream Computers Limited | Real estate | 1992 |
| Streamline Search Limited | Administrative & support | 2019 |
| Street END Lane Management Company Limited | Households | 2006 |
| Street Guardians Limited | Administrative & support | 2020 |
| Streif UK Limited | Manufacturing | 2007 |
| Strength Physio Ltd | Other services | 2026 |
| Stretch Hub Limited | Health & social care | 2025 |
| Stride & SON Auctions Ltd | Wholesale & retail | 2022 |
| Stride & SON Limited | Real estate | 2008 |
| Strobilus Chichester Limited | Hospitality | 2025 |
| Strohacker Design School Limited | Education | 2016 |
| Strong Link Ltd | Financial services | 2024 |
| Strongbox Storage Limited | Transport & logistics | 2013 |
| Strongwork Developments Limited | Construction | 2009 |
| Strop & Crop Ltd | Other services | 2026 |
| Structranova Ltd | Construction | 2025 |
| Strudwyck Engineering Limited | Manufacturing | 2024 |
| STS Mechanical Ltd | Wholesale & retail | 2008 |
| Stuart Lyons (Haulage) Limited | Transport & logistics | 1976 |
| Stuart Lyons Limited | Extraterritorial | 2008 |
| Stubcroft Farm Campsite Limited | Hospitality | 2016 |
| Student Capital Invitational Limited | Information & communication | 2026 |
| Studio 1 Services Ltd | Education | 2025 |
| Studio 13 Design Ltd | Wholesale & retail | 2021 |
| Studio 44 Reformer Pilates Ltd | Arts & recreation | 2023 |
| Studio Fuse Limited | Real estate | 2021 |
| Studio Magpie Limited | Professional & scientific | 2025 |
| Studio Outside in Limited | Wholesale & retail | 2023 |
| Studio Tolcher Ltd | Professional & scientific | 2020 |
| Studio X LAB Ltd | Manufacturing | 2026 |
| Studiomoo Design Ltd | Professional & scientific | 2019 |
| Studios for Students Ltd | Real estate | 2017 |
| Studyportals Limited | Education | 2023 |
| Stylus Groove Ltd | Administrative & support | 2021 |
| Subtown Studios Ltd | Information & communication | 2016 |
| Sudley Villas Residents Association Limited | Households | 2005 |
| Suduka Limited | Health & social care | 2019 |
| Sugar Coat Spraying Limited | Construction | 2022 |
| Sugarcoat Limited | Real estate | 2018 |
| Sugarhiccup Limited | Hospitality | 2009 |
| Sujo Group Ltd | Financial services | 2020 |
| Suki's Blend CIC | Hospitality | 2024 |
| Sulis Student Services (Bath) Limited | Real estate | 2001 |
| Summer Lovin Ltd | Other services | 2025 |
| Summer Palace Selsey Limited | Hospitality | 2013 |
| Summerhouse Investments Ltd | Health & social care | 2012 |
| Summersdale Limited | Wholesale & retail | 2012 |
| Summersdale Place Management Ltd | Households | 2018 |
| Summit Roofing Contractors Limited | Construction | 2025 |