| Salpro Limited | Other services | 2023 |
| Salt Architecture Ltd | Professional & scientific | 2024 |
| Salt Survey Ltd | Professional & scientific | 1999 |
| Salthill Consulting Limited | Professional & scientific | 2015 |
| Salthill Farm Ltd | Agriculture & fishing | 2023 |
| Saltire Dental Care Limited | Health & social care | 2013 |
| SAM Kyte Landscapes Ltd | Administrative & support | 2020 |
| SAM Morray Design Limited | Arts & recreation | 2011 |
| SAM New Designs Ltd | Wholesale & retail | 2018 |
| SAM Todd Limited | Professional & scientific | 2024 |
| Sam's Maintenance Ltd | Wholesale & retail | 2024 |
| Samadhi Services Ltd | Wholesale & retail | 2026 |
| Samantha Jane Dance Company Ltd | Education | 2024 |
| Samarjit Ventures Limited | Real estate | 2022 |
| Samples for Schools Limited | Wholesale & retail | 2017 |
| Sampson Boat Co Limited | Manufacturing | 2019 |
| Sampson Concrete Services Ltd | Construction | 2012 |
| Samridhi Properties Ltd | Real estate | 2026 |
| Samson Carpentry Ltd | Construction | 2025 |
| Samuel Prior Rail Consultants Limited | Transport & logistics | 2024 |
| Sanctioned Property Securities Limited | Real estate | 1973 |
| Sand Property Company Limited | Real estate | 2006 |
| Sandbarn Holdings Limited | Financial services | 2026 |
| Sanden Business Solutions Ltd | Professional & scientific | 2007 |
| Sandhax Ltd | Information & communication | 2025 |
| Sandhurst Instruments Limited | Professional & scientific | 1999 |
| Sandy Action Limited | Professional & scientific | 2024 |
| Sandy Lane Properties Limited | Real estate | 2015 |
| Sange Property Company Limited | Real estate | 2007 |
| Sanjupoppy Ltd | Health & social care | 2019 |
| Sankofa Management Limited | Hospitality | 2022 |
| Santiagos Gelato Ltd | Hospitality | 2025 |
| Sanuri Limited | Health & social care | 2016 |
| Sanven Corporation Ltd | Hospitality | 2015 |
| Sarah Foskett Limited | Professional & scientific | 2009 |
| Sarah Owen Associates Holdings Ltd | Financial services | 2025 |
| Sarah Owen Associates Ltd | Information & communication | 2024 |
| Sarga Healthcare Chichester Limited | Administrative & support | 2026 |
| Sarndbourne Properties Limited | Hospitality | 1975 |
| Sartori Developments Ltd | Construction | 2019 |
| Sartori Holdings Ltd | Real estate | 2025 |
| SAS Foodservices Ltd | Wholesale & retail | 2016 |
| SAS Scaffolding (Southern) Ltd | Construction | 2024 |
| Saske Voievod Ltd | Transport & logistics | 2024 |
| Satellite Computing Limited | Professional & scientific | 1996 |
| Satelyx Ltd | Manufacturing | 2023 |
| Sauna Spirit Limited | Other services | 2024 |
| Saunders Property Group Ltd | Real estate | 2022 |
| Saunders Property Holdings Ltd | Real estate | 2022 |
| Saunders Therapeutic Services Ltd | Health & social care | 2015 |
| Savages Personal Management Limited | Administrative & support | 2016 |
| Savina Business Consulting Limited | Professional & scientific | 2024 |
| Savorsend Ltd | Administrative & support | 2020 |
| Sawdust & Shavings Ltd | Manufacturing | 2017 |
| Saxon Meadow Tangmere Limited | Households | 1987 |
| SB Sea Foods Ltd | Agriculture & fishing | 2025 |
| SBB Dental Ltd | Health & social care | 2026 |
| SBB Investments Ltd | Financial services | 2025 |
| SBR Turfing Ltd | Extraterritorial | 2025 |
| Scabbers Ltd | Real estate | 2017 |
| Scac Properties Limited | Real estate | 2020 |
| Scaffolding Supplies for Sale Ltd | Construction | 2017 |
| Scaffolding Surrey Ltd | Construction | 2022 |
| Scale Rule Design Ltd | Wholesale & retail | 2020 |
| Scalechain Ltd | Professional & scientific | 2024 |
| Scandinavian Estates Limited | Professional & scientific | 2009 |
| SCF Business 2019 Limited | Professional & scientific | 2012 |
| SCG Developments Ltd | Real estate | 2016 |
| Schafer & Gaspari Limited | Administrative & support | 2024 |
| School House Farm Limited | Construction | 2016 |
| School Improvement Associates Ltd | Education | 2010 |
| Science of Shopping Limited | Professional & scientific | 2014 |
| Scissor Shed Ltd | Other services | 2017 |
| Scmg Stable Management Limited | Information & communication | 2017 |
| Scollon Limited | Professional & scientific | 2011 |
| Scope West Sussex | Health & social care | 2005 |
| Scotri Limited | Construction | 2022 |
| Scott Mayes Plumbing and Heating Ltd | Construction | 2022 |
| Scotty Ventures Limited | Other services | 2017 |
| Scowbell Limited | Professional & scientific | 2022 |
| Scripted Links Limited | Information & communication | 2015 |
| Sd-Fx Limited | Administrative & support | 2009 |
| SDC West Sussex Limited | Construction | 2024 |
| SDH Business Solutions Limited | Information & communication | 2016 |
| Sdps Group Limited | Hospitality | 2021 |
| Sea Bass Flies Ltd | Wholesale & retail | 2020 |
| Sea Breeze Laundry Ltd | Other services | 2020 |
| Sea Current Turbine Power Ltd | Construction | 2020 |
| Sea GOD Ltd | Wholesale & retail | 2024 |
| Sea Security Solutions Limited | Administrative & support | 2023 |
| Sea Soul Mindfulness Limited | Health & social care | 2022 |
| Seabrook Parks Holdco Limited | Financial services | 2021 |
| Seabrook Parks Limited | Hospitality | 1997 |
| Seafront Amusements Limited | Arts & recreation | 1996 |
| Seaglow Media Limited | Professional & scientific | 2021 |
| Sealand Aerial Photography Limited | Professional & scientific | 2004 |
| Sealutions Marine Ltd | Manufacturing | 2023 |
| Seaplanner Limited | Professional & scientific | 2007 |
| Search & Selection UK Limited | Administrative & support | 2023 |
| Seaview Blinds Limited | Manufacturing | 2020 |